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Esx1
Gene Detail
 Symbol
Name
ID
Esx1
extraembryonic, spermatogenesis, homeobox 1
MGI:1096388
Synonyms Spx1
Feature Type protein coding gene
Genetic Map
Chromosome X
59.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:137115397-137122083 bp, - strand
From VEGA annotation of GRCm38

  6687 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Esx1
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
 
Hemizygous males and heterozygous females who inherit a null targeted mutation from their mothers exhibit defects in the labyrinthine layer of the placenta resulting in impaired vascularization and reduced birth weights. Adult mutant weights are normal.
 
Interactions
Esx1 interacts with 21 markers (Mir92-1, Mir103-1, Mir103-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process blood vessel development, labyrinthine layer blood vessel development, ...
Component nucleus
Function DNA binding
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (234)    Tissues (73)    Images (36)
Theiler Stages: 2, 3, 11, 13, 14, 17, 21, 22, 23, 28
Assay TypeResults
RNA in situ 198
RT-PCR 36
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(3) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018836 (Evidence)
Ensembl Gene ModelENSMUSG00000023443 (Evidence)
Entrez Gene13984 (Evidence)
UniGene8017
DFCITC1590409
DoTSDT.40138461, DT.87049569
NIA Mouse Gene IndexU041252
Consensus CDS ProjectCCDS53199.1
International Mouse Knockout Project StatusEsx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018836 VEGA Gene Model | MGI Sequence Detail 6687 C57BL/6J ±  kb
transcript OTTMUST00000045322 VEGA | MGI Sequence Detail 1600 Not Applicable 
polypeptide OTTMUSP00000020386 VEGA | MGI Sequence Detail 382 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
References (Earliest) J:42032 Branford WW, et al., Spx1, a novel X-linked homeobox gene expressed during spermatogenesis. Mech Dev. 1997 Jul;65(1-2):87-98
(Latest) J:183999 Ouseph MM, et al., Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory