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Esx1 Gene Detail
Summary
  • Symbol
    Esx1
  • Name
    extraembryonic, spermatogenesis, homeobox 1
  • Synonyms
    Spx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096388
    NCBI Gene: 13984
Location & Maps
more
  • Sequence Map
    ChrX:137115397-137122083 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6687 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ESX1, ESX homeobox 1
  • Human Ortholog
    ESX1, ESX homeobox 1
    Orthology source: HGNC
  • Synonyms
    ESX1L, ESXR1
  • Links
    NCBI Gene ID: 80712
    neXtProt AC: NX_Q8N693

  • Chr Location
    Xq22.1; chrX:104250038-104254918 (-)  GRCh38.p2

  • HCOP
    human homology predictions: ESX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Targeted
    1
  • Incidental Mutations
Hemizygous males and heterozygous females who inherit a null targeted mutation from their mothers exhibit defects in the labyrinthine layer of the placenta resulting in impaired vascularization and reduced birth weights. Adult mutant weights are normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018836 VEGA Gene Model | MGI Sequence Detail 6687 C57BL/6J ±  kb
transcript OTTMUST00000045322 VEGA | MGI Sequence Detail 1600 Not Applicable  
polypeptide OTTMUSP00000020386 VEGA | MGI Sequence Detail 382 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    11 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 14
    Genomic 3
    cDNA 10
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 21
    Gene Ontology 2
    Phenotypes 1
  • Earliest
    J:42032 Branford WW, et al., Spx1, a novel X-linked homeobox gene expressed during spermatogenesis. Mech Dev. 1997 Jul;65(1-2):87-98
  • Latest
    J:183999 Ouseph MM, et al., Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory