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Hsd17b2
Gene Detail
 Symbol
Name
ID
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
MGI:1096386
Synonyms 17 HSD type 2
Feature Type protein coding gene
Genetic Map
Chromosome 8
64.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:117701946-117759029 bp, + strand
From NCBI annotation of GRCm38

  57084 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:99709  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: retinol dehydrogenase
Gene Tree: Hsd17b2

Human
homologs
Human Homolog HSD17B2, hydroxysteroid (17-beta) dehydrogenase 2
NCBI Gene ID 3294
neXtProt AC  NX_P37059
Human Synonyms  EDH17B2, HSD17, SDR9C2
Human Chr (Location)  16q24.1-q24.2; chr16:82035237-82098534 (+)  GRCh38
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
 
Mice homozygous for disruptions in this gene display embryonic lethality starting at E11.5 and placenta defects. The few mutants that survive to birth exhibit enlarged brain ventricles, cerebral cortex abnormalities and a single kidney.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process androgen biosynthetic process, estrogen biosynthetic process, ...
Component integral component of membrane, intracellular membrane-bounded organelle, ...
Function estradiol 17-beta-dehydrogenase activity, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (46)    Tissues (10)    Images (20)
Theiler Stages: 23, 24, 25, 26
Assay TypeResults
RNA in situ 38
RT-PCR 8
cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000031844 (Evidence)
Entrez Gene15486 (Evidence)
UniGene276466
DFCITC1581748, TC1664806
DoTSDT.495502, DT.55209348, DT.91336101, DT.94314044
NIA Mouse Gene IndexU009870
EC1.1.1.239, 1.1.1.62
Consensus CDS ProjectCCDS40491.1
International Mouse Knockout Project StatusHsd17b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15486 NCBI Gene Model | MGI Sequence Detail 57084 C57BL/6J ±  kb
transcript NM_008290 RefSeq | MGI Sequence Detail 1280 C57BL/6 
polypeptide P51658 UniProt | EBI | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008779 estradiol 17-beta-dehydrogenase 2
Graphical View of Protein Domain Structure
References (Earliest) J:41672 Mustonen MVJ, et al., Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues. Biochem J. 1997 Jul 1;325(Pt 1):199-205
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(40)
Other
accession IDs
MGI:2142476, MGI:2142477, MGI:2142485

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory