Hsd17b2
Gene Detail

Symbol Name ID

Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 MGI:1096386

Synonyms

17 HSD type 2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

64.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:117701946-117759029 bp, + strand From NCBI annotation of GRCm38   57084 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:99709  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: retinol dehydrogenase
Gene Tree: Hsd17b2

Human homologs

Human Homolog		HSD17B2, hydroxysteroid (17-beta) dehydrogenase 2
NCBI Gene ID		3294
neXtProt AC		NX_P37059
Human Synonyms		EDH17B2, HSD17, SDR9C2
Human Chr (Location)		16q24.1-q24.2; chr16:82068858-82132139 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for disruptions in this gene display embryonic lethality starting at E11.5 and placenta defects. The few mutants that survive to birth exhibit enlarged brain ventricles, cerebral cortex abnormalities and a single kidney.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	androgen biosynthetic process, estrogen biosynthetic process, ...
Component	integral to membrane, intracellular membrane-bounded organelle, ...
Function	estradiol 17-beta-dehydrogenase activity, oxidoreductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (46)    Tissues (10)    Images (20)
Theiler Stages: 23, 24, 25, 26

Assay Type	Results
RNA in situ	38
RT-PCR	8

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000031844 (Evidence)
Entrez Gene	15486 (Evidence)
UniGene	276466
DFCI	TC1581748, TC1664806
DoTS	DT.495502, DT.55209348, DT.91336101, DT.94314044
NIA Mouse Gene Index	U009870
EC	1.1.1.239, 1.1.1.62
Consensus CDS Project	CCDS40491.1
International Mouse Knockout Project Status	Hsd17b2

Sequences

Length	Strain/Species
genomic	15486	NCBI Gene Model | MGI Sequence Detail	57084	C57BL/6J
transcript	NM_008290	RefSeq | MGI Sequence Detail	1280	C57BL/6
polypeptide	P51658	UniProt | EBI | MGI Sequence Detail	381	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(133 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002347	Glucose/ribitol dehydrogenase
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR020904	Short-chain dehydrogenase/reductase, conserved site
InterPro	IPR002198	Short-chain dehydrogenase/reductase SDR
Protein Ontology	PR:000008779	estradiol 17-beta-dehydrogenase 2

Graphical View of Protein Domain Structure

References

(Earliest) J:41672 Mustonen MVJ, et al., Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues. Biochem J. 1997 Jul 1;325(Pt 1):199-205
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(41)

Other accession IDs

MGI:2142476, MGI:2142477, MGI:2142485