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Hsd17b2
Gene Detail
Symbol

Name
ID
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
MGI:1096386
Synonyms
17 HSD type 2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
64.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:117701946-117759029 bp, + strand
From Ensembl annotation of GRCm38

  57084 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:99709  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HSD17B2
Protein SuperFamily: retinol dehydrogenase
Gene Tree: Hsd17b2

Human
homologs
HSD17B2, hydroxysteroid (17-beta) dehydrogenase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3294
neXtProt AC: NX_P37059

Human Synonyms: EDH17B2, HSD17, SDR9C2

Human Chr (Location): 16q24.1-q24.2; chr16:82035237-82098534 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display embryonic lethality starting at E11.5 and placenta defects. The few mutants that survive to birth exhibit enlarged brain ventricles, cerebral cortex abnormalities and a single kidney.
 
Interactions
Hsd17b2 interacts with 49 markers (Mir18, Mir18b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (46)    Tissues (10)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 38
RT-PCR 8
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN hsd17b2    NEW 
Molecular
reagents
All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000031844 (Evidence)
Entrez Gene 15486 (Evidence)
UniGene 276466
DFCI TC1664806, TC1581748
DoTS DT.91336101, DT.55209348, DT.495502, DT.94314044
NIA Mouse Gene Index U009870
EC 1.1.1.62, 1.1.1.239
Consensus CDS Project CCDS40491.1
International Mouse Phenotyping Consortium Status Hsd17b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031844 Ensembl Gene Model | MGI Sequence Detail 57084 C57BL/6J ±  kb
transcript ENSMUST00000034304 Ensembl | MGI Sequence Detail 1280 Not Applicable 
polypeptide ENSMUSP00000034304 Ensembl | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008779 estradiol 17-beta-dehydrogenase 2
References
(Earliest) J:41672 Mustonen MVJ, et al., Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues. Biochem J. 1997 Jul 1;325(Pt 1):199-205
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(39)
Other
accession IDs
MGI:2142476, MGI:2142477, MGI:2142485

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory