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Hsd17b2 Gene Detail
Summary
  • Symbol
    Hsd17b2
  • Name
    hydroxysteroid (17-beta) dehydrogenase 2
  • Synonyms
    17 HSD type 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096386
    NCBI Gene: 15486
  • Gene Overview
    MyGene.info: HSD17B2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:117701904-117759027 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 64.82 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096386
protein coding gene Chr8:117700982-117759030 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034176
protein coding gene Chr8:120911990-120982095 (+)
A/J MGP_AJ_G0034156
protein coding gene Chr8:115959867-116017208 (+)
AKR/J MGP_AKRJ_G0034083
protein coding gene Chr8:119332144-119394352 (+)
BALB/cJ MGP_BALBcJ_G0034150
protein coding gene Chr8:116157095-116216040 (+)
C3H/HeJ MGP_C3HHeJ_G0033861
protein coding gene Chr8:120061773-120123959 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034670
protein coding gene Chr8:124977891-125057046 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031612
protein coding gene Chr8:108884621-108945438 (+)
CAST/EiJ MGP_CASTEiJ_G0033188
protein coding gene Chr8:119943800-120007430 (+)
CBA/J MGP_CBAJ_G0033834
protein coding gene Chr8:129528287-129598203 (+)
DBA/2J MGP_DBA2J_G0033990
protein coding gene Chr8:115185199-115242872 (+)
FVB/NJ MGP_FVBNJ_G0033933
protein coding gene Chr8:114199960-114257183 (+)
LP/J MGP_LPJ_G0034079
protein coding gene Chr8:121044443-121110022 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033980
protein coding gene Chr8:132077222-132143057 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034688
protein coding gene Chr8:119449584-119515100 (+)
PWK/PhJ MGP_PWKPhJ_G0032890
protein coding gene Chr8:114907350-114972406 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032730
protein coding gene Chr8:118162176-118228398 (+)
WSB/EiJ MGP_WSBEiJ_G0033304
protein coding gene Chr8:120150629-120216301 (+)



Homology
more
  • Human Ortholog
    HSD17B2, hydroxysteroid 17-beta dehydrogenase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSD17B2, hydroxysteroid 17-beta dehydrogenase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EDH17B2, HSD17, SDR9C2
  • Links
    NCBI Gene ID: 3294
    neXtProt AC: NX_P37059
    UniProt: P37059

  • Chr Location
    16q23.3; chr16:82035237-82098534 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display embryonic lethality starting at E11.5 and placenta defects. The few mutants that survive to birth exhibit enlarged brain ventricles, cerebral cortex abnormalities and a single kidney.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031844 Ensembl Gene Model | MGI Sequence Detail 57124 C57BL/6J ±  kb
    transcript ENSMUST00000034304 Ensembl | MGI Sequence Detail 1320 Not Applicable  
    polypeptide ENSMUSP00000034304 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 40
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142476, MGI:2142477, MGI:2142485
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 3
    • Earliest
      J:41672 Mustonen MVJ, et al., Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues. Biochem J. 1997 Jul 1;325(Pt 1):199-205
    • Latest
      J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory