About   Help   FAQ
Arntl
Gene Detail
 Symbol
Name
ID
Arntl
aryl hydrocarbon receptor nuclear translocator-like
MGI:1096381
Synonyms Arnt3, bHLHe5, Bmal1, MOP3
Feature Type protein coding gene
Genetic Map
Chromosome 7
59.17 cM, cytoband F2-F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:113207465-113314122 bp, + strand
From Ensembl annotation of GRCm38

  106658 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:910  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Arntl

Human
homologs
Human Homolog ARNTL, aryl hydrocarbon receptor nuclear translocator-like
NCBI Gene ID 406
neXtProt AC  NX_O00327
Human Synonyms  bHLHe5, BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC
Human Chr (Location)  11p15; chr11:13277734-13387266 (+)  GRCh38
Alleles
and
phenotypes
All alleles(109) : Gene trapped(102) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in abnormal light/dark cycle activity and decreases overall activity levels.
 
Human Diseases Modeled Using Mouse Arntl (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Gene Ontology
(GO)
classifications
All GO classifications: (87 annotations)
Process circadian regulation of gene expression, circadian rhythm, ...
Component chromatoid body, cytoplasm, ...
Function aryl hydrocarbon receptor binding, bHLH transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (187)    Tissues (132)    Images (29)
Theiler Stages: 1, 2, 3, 4, 5, 17, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 135
Northern blot 8
RT-PCR 40
cDNA source data(50)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(54) cDNA(51) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000055116 (Evidence)
Entrez Gene11865 (Evidence)
UniGene440371
DFCITC1577063, TC1595418, TC1611296, TC1637310, TC1698183, TC1698649
DoTSDT.101372098, DT.103561983, DT.111014059, DT.40171997, DT.489401, DT.91335434, DT.97405406
NIA Mouse Gene IndexU008650, U232917
PDB4F3L
Consensus CDS ProjectCCDS40092.1
International Mouse Knockout Project StatusArntl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055116 Ensembl Gene Model | MGI Sequence Detail 106658 C57BL/6J ±  kb
transcript ENSMUST00000047321 Ensembl | MGI Sequence Detail 2904 Not Applicable 
polypeptide ENSMUSP00000046235 Ensembl | MGI Sequence Detail 626 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(22) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(1035 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001067 Nuclear translocator
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
Protein Ontology PR:000004305 aryl hydrocarbon receptor nuclear translocator-like protein 1
References (Earliest) J:47665 Hogenesch JB, et al., The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5474-9
(Latest) J:209571 Goriki A, et al., A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 2014 Apr;12(4):e1001839
All references(188)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory