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Arntl Gene Detail
Summary
  • Symbol
    Arntl
  • Name
    aryl hydrocarbon receptor nuclear translocator-like
  • Synonyms
    Arnt3, bHLHe5, Bmal1, MOP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096381
    NCBI Gene: 11865
Location & Maps
more
  • Sequence Map
    Chr7:113207465-113314122 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106658 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ARNTL, aryl hydrocarbon receptor nuclear translocator like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARNTL, aryl hydrocarbon receptor nuclear translocator like
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHe5, BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC
  • Links
    NCBI Gene ID: 406
    neXtProt AC: NX_O00327

  • Chr Location
    11p15; chr11:13277727-13387811 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 910
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: ARNTL
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Arntl mouse models

Human Disease Mouse Models
       Priapism, Familial Idiopathic   OMIM: 176620 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    149 phenotypes from 9 alleles in 16 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    106 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    114
  • Gene trapped
    102
  • Radiation induced
    1
  • Targeted
    9
  • Transgenic
    2
  • Genomic Mutations
    1 involving Arntl
  • Incidental Mutations
Homozygous mutation of this gene results in abnormal light/dark cycle activity and decreases overall activity levels. Mice homozygous for another knock-out allele exhibit loss of circadian rhythm in locomotor activity, dyslipidemia, ectopic fat formationand altered energy homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055116 Ensembl Gene Model | MGI Sequence Detail 106658 C57BL/6J ±  kb
transcript ENSMUST00000047321 Ensembl | MGI Sequence Detail 2904 Not Applicable  
polypeptide ENSMUSP00000046235 Ensembl | MGI Sequence Detail 626 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1035 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    cDNA 51
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 216
    Developmental Gene Expression 15
    Diseases 1
    Gene Ontology 67
    Phenotypes 106
  • Earliest
    J:47665 Hogenesch JB, et al., The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5474-9
  • Latest
    J:226753 Perelis M, et al., Pancreatic beta cell enhancers regulate rhythmic transcription of genes controlling insulin secretion. Science. 2015 Nov 6;350(6261):aac4250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory