Psmb10 MGI Mouse Gene Detail - MGI:1096380 - proteasome (prosome, macropain) subunit, beta type 10

Symbol

Psmb10
Name

proteasome (prosome, macropain) subunit, beta type 10
Synonyms

Mecl-1, Mecl1

Feature Type

protein coding gene
IDs

MGI:1096380
NCBI Gene: 19171
Alliance

genome feature page
Transcription Start Sites

15 TSS

Sequence Map

Chr8:106662360-106665024 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.06 cM
Mapping Data

3 experiments

SNPs within 2kb

148 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096380	protein coding gene	Chr8:106662360-106665076 (-)
129S1/SvImJ	ENSMUSG00200014047	protein coding gene	Chr8:100942238-100945024 (-)
A/J	ENSMUSG00195020554	protein coding gene	Chr8:101264718-101267504 (-)
AKR/J	ENSMUSG00220014973	protein coding gene	Chr8:101407358-101410144 (-)
BALB/cJ	ENSMUSG00180022823	protein coding gene	Chr8:101270520-101273306 (-)
C3H/HeJ	ENSMUSG00175024379	protein coding gene	Chr8:101327229-101330015 (-)
C57BL/6NJ	ENSMUSG00215020220	protein coding gene	Chr8:100941571-100944357 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031504	protein coding gene	Chr8:97066482-97069149 (-)
CAST/EiJ	ENSTCUG00005020901	protein coding gene	Chr8:100708972-100711761 (-)
CBA/J	ENSMUSG00210033808	protein coding gene	Chr8:101254947-101257733 (-)
DBA/2J	ENSMUSG00185005042	protein coding gene	Chr8:107363704-107366490 (-)
FVB/NJ	ENSMUSG00205010873	protein coding gene	Chr8:100239270-100242056 (-)
JF1/MsJ	ENSUMUG00000008449	protein coding gene	Chr8:109696893-109699679 (-)
LP/J	ENSMUSG00230031211	protein coding gene	Chr8:111044108-111046894 (-)
NOD/ShiLtJ	ENSMUSG00190018756	protein coding gene	Chr8:101394126-101396912 (-)
NZO/HlLtJ	ENSMUSG00225022130	protein coding gene	Chr8:114394650-114397436 (-)
PWK/PhJ	ENSLUMG00010003823	protein coding gene	Chr8:101191181-101193970 (-)
SPRET/EiJ	ENSMSPG00010036169	protein coding gene	Chr8:103255920-103259235 (-)
WSB/EiJ	ENSIUOG00005032157	protein coding gene	Chr8:102074859-102077645 (-)

Human Ortholog

PSMB10, proteasome 20S subunit beta 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSMB10, proteasome 20S subunit beta 10
Synonyms

beta2i, IMD121, LMP10, MECL1, PRAAS5
Links

HGNC:9538

NCBI Gene ID: 5699

UniProt: P40306
Chr Location

16q22.1; chr16:67934506-67936864 (-) GRCh38

MGI Vertebrate Homology

Psmb10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PSMB10
Gene Tree

Psmb10

Diseases

2 with human PSMB10 associations

				Human Disease	Mouse Models
				immunodeficiency 121 IDs immunodeficiency 121 DOID:0061087 OMIM:620807
				proteosome-associated autoinflammatory syndrome 5 IDs proteosome-associated autoinflammatory syndrome 5 DOID:0060919 OMIM:619175

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

28 phenotypes from 2 alleles in 5 genetic backgrounds
5 phenotypes from multigenic genotypes
52 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (ENU)

1
Endonuclease-mediated

3
Gene trapped

9
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice have a reduced number of splenic CD8 T cells with defects in proliferation and an altered T cell receptor repertoire to viral antigens.

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All GO Annotations

18
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

613
Tissues

12
cDNA Data

91
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

2
UniProt

4
CCDS

CCDS22621.1

Ensembl

ENSMUSG00000031897 (Evidence)
NCBI Gene

19171

			Length	Strain/Species	Flank
genomic	19171	NCBI Gene Model \| MGI Sequence Detail	2665	C57BL/6J	± kb
transcript	NM_013640	RefSeq \| MGI Sequence Detail	1270	ZRU/MplStud
polypeptide	O35955	UniProt \| EBI \| MGI Sequence Detail	273	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013370 proteasome subunit beta type-10

(term hierarchy)
PDB

3UNF, 3UNH
EC

3.4.25.1
InterPro Domains

IPR029055 Nucleophile aminohydrolases, N-terminal

IPR000243 Peptidase T1A, proteasome beta-subunit

IPR024689 Proteasome beta subunit, C-terminal

IPR016050 Proteasome beta-type subunit, conserved site

IPR023333 Proteasome B-type subunit

IPR001353 Proteasome, subunit alpha/beta
GlyGen

O35955 1 site

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All nucleic 95

Genomic 2

cDNA 91

Primer pair 2

Microarray probesets 3

Summaries

All 98

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 52
Earliest

J:40353 Stohwasser R, et al., Molecular cloning of the mouse proteasome subunits MC14 and MECL-1: reciprocally regulated tissue expression of interferon-gamma-modulated proteasome subunits. Eur J Immunol. 1997 May;27(5):1182-7
Latest

J:382919 Woo MS, et al., The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis. Cell. 2025 Aug 21;188(17):4567-4585.e32

TSS for Psmb10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr82733	Chr8:106666753-106666777 (-)	-1,741 bp
Tssr82732	Chr8:106666692-106666729 (-)	-1,687 bp
Tssr82731	Chr8:106666534-106666545 (-)	-1,516 bp
Tssr82730	Chr8:106666458-106666496 (-)	-1,453 bp
Tssr82729	Chr8:106666411-106666419 (-)	-1,391 bp
Tssr82728	Chr8:106665062-106665077 (-)	-46 bp
Tssr82727	Chr8:106665016-106665053 (-)	-11 bp
Tssr82726	Chr8:106664678-106664766 (-)	302 bp
Tssr82725	Chr8:106664648-106664674 (-)	363 bp
Tssr82724	Chr8:106663658-106663674 (-)	1,358 bp
Tssr82723	Chr8:106663629-106663657 (-)	1,381 bp
Tssr82722	Chr8:106663604-106663615 (-)	1,414 bp
Tssr82721	Chr8:106663587-106663598 (-)	1,431 bp
Tssr82720	Chr8:106663524-106663578 (-)	1,473 bp
Tssr82719	Chr8:106663468-106663480 (-)	1,550 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24