About   Help   FAQ
Psmb10
Gene Detail
Symbol

Name
ID
Psmb10
proteasome (prosome, macropain) subunit, beta type 10
MGI:1096380
Synonyms
Mecl1, Mecl-1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:105935728-105938392 bp, - strand
From Ensembl annotation of GRCm38

  2665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20616  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Psmb10

Human
homologs
Human Homolog PSMB10, proteasome (prosome, macropain) subunit, beta type, 10
NCBI Gene ID 5699
neXtProt AC  NX_P40306
Human Synonyms  beta2i, LMP10, MECL1
Human Chr (Location)  16q22.1; chr16:67934504-67936877 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(10) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice have a reduced number of splenic CD8 T cells with defects in proliferation and an altered T cell receptor repertoire to viral antigens.
 
Interactions
Psmb10 interacts with 5 markers (Mir467b, Mir467e, Mir467h, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell morphogenesis, proteolysis, ...
Component cytoplasm, nucleus, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (14)    Tissues (10)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
RT-PCR 10
cDNA source data(89)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(93) Genomic(2) cDNA(89) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031897 (Evidence)
Entrez Gene19171 (Evidence)
UniGene787
DFCITC1576433
DoTSDT.534830, DT.101273544
NIA Mouse Gene IndexU030189
EC3.4.25.1
PDB3UNF, 3UNH
Consensus CDS ProjectCCDS22621.1
International Mouse Knockout Project StatusPsmb10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031897 Ensembl Gene Model | MGI Sequence Detail 2665 C57BL/6J ±  kb
transcript ENSMUST00000034369 Ensembl | MGI Sequence Detail 1270 Not Applicable 
polypeptide ENSMUSP00000034369 Ensembl | MGI Sequence Detail 273 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000243 Peptidase T1A, proteasome beta-subunit
InterPro IPR024689 Proteasome beta subunit, C-terminal
InterPro IPR016050 Proteasome, beta-type subunit, conserved site
InterPro IPR023333 Proteasome B-type subunit
InterPro IPR001353 Proteasome, subunit alpha/beta
Protein Ontology PR:000013370 proteasome subunit beta type-10
References
(Earliest) J:40353 Stohwasser R, et al., Molecular cloning of the mouse proteasome subunits MC14 and MECL-1: reciprocally regulated tissue expression of interferon-gamma-modulated proteasome subunits. Eur J Immunol. 1997 May;27(5):1182-7
(Latest) J:205374 Zanker D, et al., Mixed proteasomes function to increase viral peptide diversity and broaden antiviral CD8+ T cell responses. J Immunol. 2013 Jul 1;191(1):52-9
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/23/2014
MGI 5.20
The Jackson Laboratory