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Exoc4 Gene Detail
Summary
  • Symbol
    Exoc4
  • Name
    exocyst complex component 4
  • Synonyms
    Sec8, Sec8l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096376
    NCBI Gene: 20336
  • Gene Overview
    MyGene.info: EXOC4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:33249090-33972943 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 14.59 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4676 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096376
protein coding gene Chr6:33249085-33973979 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030553
protein coding gene Chr6:31262804-32018453 (+)
A/J MGP_AJ_G0030526
protein coding gene Chr6:29941335-30664972 (+)
AKR/J MGP_AKRJ_G0030453
protein coding gene Chr6:30940037-31683764 (+)
BALB/cJ MGP_BALBcJ_G0030536
protein coding gene Chr6:30094437-30824330 (+)
C3H/HeJ MGP_C3HHeJ_G0030249
protein coding gene Chr6:30917089-31659914 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030990
protein coding gene Chr6:32060244-32836487 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028201
protein coding gene Chr6:28052950-28755161 (+)
CAST/EiJ MGP_CASTEiJ_G0029651
protein coding gene Chr6:30709478-31458902 (+)
CBA/J MGP_CBAJ_G0030227
protein coding gene Chr6:33311507-34096077 (+)
DBA/2J MGP_DBA2J_G0030371
protein coding gene Chr6:29826312-30542440 (+)
FVB/NJ MGP_FVBNJ_G0030325
protein coding gene Chr6:29610027-30321972 (+)
LP/J MGP_LPJ_G0030458
protein coding gene Chr6:31392121-32153551 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030361
protein coding gene Chr6:35652714-36471309 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031020
protein coding gene Chr6:30833402-31579709 (+)
PWK/PhJ MGP_PWKPhJ_G0029365
protein coding gene Chr6:29414500-30140369 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029201
protein coding gene Chr6:30485215-31218939 (+)
WSB/EiJ MGP_WSBEiJ_G0029727
protein coding gene Chr6:30738420-31490373 (+)



Homology
more
  • Human Ortholog
    EXOC4, exocyst complex component 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EXOC4, exocyst complex component 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SEC8, SEC8L1, Sec8p
  • Links
    NCBI Gene ID: 60412
    neXtProt AC: NX_Q96A65
    UniProt: Q96A65

  • Chr Location
    7q33; chr7:133253067-134067137 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 40654
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EXOC4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display embryonic abnormatlities. Gastrulation is not completed and mesoderm formation is abnormal. Death occurs before E10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20336 NCBI Gene Model | MGI Sequence Detail 723854 C57BL/6J ±  kb
    transcript NM_009148 RefSeq | MGI Sequence Detail 4781 C57BL/6  
    polypeptide O35382 UniProt | EBI | MGI Sequence Detail 975 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1353571
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Gene Ontology 13
      Phenotypes 16
    • Earliest
      J:79478 Friedrich G, et al., Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory