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Exoc4
Gene Detail
 Symbol
Name
ID
Exoc4
exocyst complex component 4
MGI:1096376
Synonyms Sec8, Sec8l1
Feature Type protein coding gene
Genetic Map
Chromosome 6
14.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:33249085-33973979 bp, + strand
From VEGA annotation of GRCm38

  724895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40654  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Exoc4

Human
homologs
Human Homolog EXOC4, exocyst complex component 4
NCBI Gene ID 60412
neXtProt AC  NX_Q96A65
Human Synonyms  SEC8, SEC8L1, Sec8p
Human Chr (Location)  7q31; chr7:133253067-134065761 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Endonuclease-mediated(1) Gene trapped(70) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display embryonic abnormatlities. Gastrulation is not completed and mesoderm formation is abnormal. Death occurs before E10.5.
 
Interactions
Exoc4 interacts with 275 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process establishment of cell polarity, exocytosis, ...
Component cytoplasm, dendritic shaft, ...
Function PDZ domain binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (79)    Tissues (18)    Images (30)
Theiler Stages: 9, 11, 13, 15, 17, 21, 23
Assay TypeResults
Immunohistochemistry 1
RNA in situ 63
RT-PCR 15
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000014760 (Evidence)
Ensembl Gene ModelENSMUSG00000029763 (Evidence)
Entrez Gene20336 (Evidence)
DFCITC1575487, TC1589911, TC1593793, TC1594608, TC1596933, TC1658448
DoTSDT.101738213, DT.91298577, DT.91446756, DT.94137633, DT.94254403, DT.97371348, DT.97383214
NIA Mouse Gene IndexU006654
Consensus CDS ProjectCCDS19987.1
International Mouse Knockout Project StatusExoc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014760 VEGA Gene Model | MGI Sequence Detail 724895 C57BL/6J ±  kb
transcript OTTMUST00000035033 VEGA | MGI Sequence Detail 4824 Not Applicable 
polypeptide OTTMUSP00000015637 VEGA | MGI Sequence Detail 975 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(4) UniProt(8)
Polymorphisms SNPs within 2kb(4746 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4764)
Protein-related
information
ResourceIDDescription
InterPro IPR007191 Sec8 exocyst complex component specific domain
Protein Ontology PR:000007251 exocyst complex component 4
References (Earliest) J:79478 Friedrich G, et al., Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(54)
Other
accession IDs
MGI:1353571

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory