Ybx2
Gene Detail

Symbol Name ID

Ybx2 Y box protein 2 MGI:1096372

Synonyms

MSY2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.93 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:69935796-69941605 bp, + strand From VEGA annotation of GRCm38   5810 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22942  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Y box-binding protein 1
Gene Tree: Ybx2

Human homologs

Human Homolog		YBX2, Y box binding protein 2
NCBI Gene ID		51087
neXtProt AC		NX_Q9Y2T7
Human Synonyms		CONTRIN, CSDA3, DBPC, MSY2
Human Chr (Location)		17p13.1; chr17:7191571-7197876 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous disruption of this gene leads to both male and female infertility. Spermatogenesis terminates in postmeiotic germ cells with no sperm seen in the epididymis and a marked increase of apoptosis during meiosis. Adult females exhibit a few growing follicles and no corpora lutea.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	mRNA stabilization, negative regulation of binding, ...
Component	cytoplasm, nucleus, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (65)    Tissues (32)   
Theiler Stages: 1, 2, 5, 15, 19, 20, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	2
Northern blot	12
Western blot	37
RT-PCR	8

cDNA source data(44)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) cDNA(44) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006029 (Evidence)
Ensembl Gene Model	ENSMUSG00000018554 (Evidence)
Entrez Gene	53422 (Evidence)
UniGene	29286
DFCI	TC1583125, TC1592818, TC1599386
DoTS	DT.101408030, DT.91337613, DT.97357465
NIA Mouse Gene Index	U012836
Consensus CDS Project	CCDS36200.1
International Mouse Knockout Project Status	Ybx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006029	VEGA Gene Model | MGI Sequence Detail	5810	C57BL/6J
transcript	OTTMUST00000013542	VEGA | MGI Sequence Detail	1673	Not Applicable
polypeptide	OTTMUSP00000006276	VEGA | MGI Sequence Detail	359	Not Applicable

All sequences(42) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019844	Cold-shock conserved site
InterPro	IPR011129	Cold shock protein
InterPro	IPR002059	Cold-shock protein, DNA-binding
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR016027	Nucleic acid-binding, OB-fold-like
Protein Ontology	PR:000017526	Y-box-binding protein 2

References

(Earliest) J:54015 Gu W, et al., Mammalian male and female germ cells express a germ cell-specific Y-Box protein, MSY2. Biol Reprod. 1998 Nov;59(5):1266-74
(Latest) J:194101 Yamaguchi S, et al., Tet1 controls meiosis by regulating meiotic gene expression. Nature. 2012 Dec 20;492(7429):443-7
All references(43)