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Ybx2
Gene Detail
 Symbol
Name
ID
Ybx2
Y box protein 2
MGI:1096372
Synonyms MSY2
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.93 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:69935796-69941605 bp, + strand
From VEGA annotation of GRCm38

  5810 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22942  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Y box-binding protein 1
Gene Tree: Ybx2

Human
homologs
Human Homolog YBX2, Y box binding protein 2
NCBI Gene ID 51087
neXtProt AC  NX_Q9Y2T7
Human Synonyms  CONTRIN, CSDA3, DBPC, MSY2
Human Chr (Location)  17p13.1; chr17:7288252-7294557 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
 
Homozygous disruption of this gene leads to both male and female infertility. Spermatogenesis terminates in postmeiotic germ cells with no sperm seen in the epididymis and a marked increase of apoptosis during meiosis. Adult females exhibit a few growing follicles and no corpora lutea.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process mRNA stabilization, negative regulation of binding, ...
Component cytoplasm, nucleus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (65)    Tissues (32)   
Theiler Stages: 1, 2, 5, 15, 19, 20, 21, 23, 25, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 2
Northern blot 12
Western blot 37
RT-PCR 8
cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(46) cDNA(43) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006029 (Evidence)
Ensembl Gene ModelENSMUSG00000018554 (Evidence)
Entrez Gene53422 (Evidence)
UniGene29286
DFCITC1583125, TC1592818, TC1599386
DoTSDT.101408030, DT.91337613, DT.97357465
NIA Mouse Gene IndexU012836
Consensus CDS ProjectCCDS36200.1
International Mouse Knockout Project StatusYbx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006029 VEGA Gene Model | MGI Sequence Detail 5810 C57BL/6J ±  kb
transcript OTTMUST00000013542 VEGA | MGI Sequence Detail 1673 Not Applicable 
polypeptide OTTMUSP00000006276 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(22) UniProt(5)
Polymorphisms SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019844 Cold-shock conserved site
InterPro IPR011129 Cold shock protein
InterPro IPR002059 Cold-shock protein, DNA-binding
InterPro IPR012340 Nucleic acid-binding, OB-fold
Protein Ontology PR:000017526 Y-box-binding protein 2
References (Earliest) J:54015 Gu W, et al., Mammalian male and female germ cells express a germ cell-specific Y-Box protein, MSY2. Biol Reprod. 1998 Nov;59(5):1266-74
(Latest) J:194101 Yamaguchi S, et al., Tet1 controls meiosis by regulating meiotic gene expression. Nature. 2012 Dec 20;492(7429):443-7
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory