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Erf
Gene Detail
 Symbol
Name
ID
Erf
Ets2 repressor factor
MGI:109637
Feature Type protein coding gene
Genetic Map
Chromosome 7
13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:25242561-25250761 bp, - strand
From VEGA annotation of GRCm38

  8201 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Erf

Human
homologs
Human Homolog ERF, Ets2 repressor factor
NCBI Gene ID 2077
neXtProt AC  NX_P50548
Human Synonyms  CRS4, PE2, PE-2
Human Chr (Location)  19q13; chr19:42247565-42255157 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ERF
Alleles
and
phenotypes
All alleles(39) : Gene trapped(35) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality around E10.5, reduced size, brain hypoplasia, defects in extraembryonic tissue formation affecting the chorion, allantois, placental labyrinth and umbilical cord, and increase in apoptosis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chorio-allantoic fusion, ectodermal cell differentiation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (74)    Tissues (68)    Images (5)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 21, 23, 26, 28
Assay TypeResults
RNA in situ 59
RT-PCR 15
cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(38) Genomic(1) cDNA(34) Primer pair(2) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000029200 (Evidence)
Ensembl Gene ModelENSMUSG00000040857 (Evidence)
Entrez Gene13875 (Evidence)
UniGene8068
DFCITC1581351
DoTSDT.487130
NIA Mouse Gene IndexU028271
Consensus CDS ProjectCCDS20978.1
International Mouse Knockout Project StatusErf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029200 VEGA Gene Model | MGI Sequence Detail 8201 C57BL/6J ±  kb
transcript OTTMUST00000072404 VEGA | MGI Sequence Detail 3505 Not Applicable 
polypeptide OTTMUSP00000037262 VEGA | MGI Sequence Detail 551 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007172 ETS domain-containing transcription factor ERF
References (Earliest) J:39443 Liu D, et al., ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes. Oncogene. 1997 Mar 27;14(12):1445-51
(Latest) J:198059 Twigg SR, et al., Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. Nat Genet. 2013 Mar;45(3):308-13
All references(45)
Other
accession IDs
MGD-MRK-39636

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory