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Erf Gene Detail
Summary
  • Symbol
    Erf
  • Name
    Ets2 repressor factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:109637
    NCBI Gene: 13875
  • Gene Overview
    MyGene.info: ERF
Location & Maps
more
  • Sequence Map
    Chr7:25242561-25250761 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8201 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.73 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ERF, ETS2 repressor factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ERF, ETS2 repressor factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRS4, PE2, PE-2
  • Links
    NCBI Gene ID: 2077
    neXtProt AC: NX_P50548

  • Chr Location
    19q13; chr19:42247561-42255164 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68516
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: ERF
  • Gene Tree
    Erf
Human Diseases
more
  • Diseases
    1 with human ERF associations

Human Disease Mouse Models
       Craniosynostosis 4; CRS4   OMIM: 600775
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    40
  • Gene trapped
    35
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a null allele exhibit embryonic lethality around E10.5, reduced size, brain hypoplasia, defects in extraembryonic tissue formation affecting the chorion, allantois, placental labyrinth and umbilical cord, and increase in apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029200 VEGA Gene Model | MGI Sequence Detail 8201 C57BL/6J ±  kb
transcript OTTMUST00000072404 VEGA | MGI Sequence Detail 3505 Not Applicable  
polypeptide OTTMUSP00000037262 VEGA | MGI Sequence Detail 551 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    22 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR000418 Ets domain
    IPR032925 ETS domain-containing transcription factor ERF
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 38
    Genomic 1
    cDNA 34
    Primer pair 2
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-39636
References
more
  • Summaries
    All 42
    Developmental Gene Expression 10
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:39443 Liu D, et al., ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes. Oncogene. 1997 Mar 27;14(12):1445-51
  • Latest
    J:198059 Twigg SR, et al., Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. Nat Genet. 2013 Mar;45(3):308-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory