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Ap1b1 Gene Detail
Summary
  • Symbol
    Ap1b1
  • Name
    adaptor protein complex AP-1, beta 1 subunit
  • Synonyms
    Adtb1, b2b1660Clo, beta-prime adaptin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096368
    NCBI Gene: 11764
  • Gene Overview
    MyGene.info: AP1B1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:4986824-5042729 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55906 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.15 cM, cytoband A2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    AP1B1, adaptor related protein complex 1 subunit beta 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AP1B1, adaptor related protein complex 1 subunit beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADTB1, AP105A, BAM22, CLAPB2
  • Links
    NCBI Gene ID: 162
    neXtProt AC: NX_Q10567
    UniProt: Q10567

  • Chr Location
    22q12.2; chr22:29327680-29388583 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Ap1b1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    20 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005076 VEGA Gene Model | MGI Sequence Detail 55906 C57BL/6J ±  kb
    transcript OTTMUST00000011327 VEGA | MGI Sequence Detail 3735 Not Applicable  
    polypeptide OTTMUSP00000005282 VEGA | MGI Sequence Detail 923 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      417 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000004090 AP-1 complex subunit beta-1
    • InterPro Domains
      IPR016342 AP-1/2/4 complex subunit beta
      IPR026739 AP complex subunit beta
      IPR000225 Armadillo
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR015151 Beta-adaptin appendage, C-terminal subdomain
      IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
      IPR013041 Clathrin adaptor, appendage, Ig-like subdomain superfamily
      IPR013037 Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
      IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
      IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
      IPR032682 Condensin complex subunit 1, C-terminal
      IPR012295 TBP domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 5
      cDNA 14
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5433318
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:42384 Guilbaud C, et al., Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization. Mamm Genome. 1997 Sep;8(9):651-6
    • Latest
      J:231949 San Agustin JT, et al., Genetic link between renal birth defects and congenital heart disease. Nat Commun. 2016;7:11103

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory