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Gene Detail
adaptor protein complex AP-1, beta 1 subunit
Synonyms Adtb1, beta-prime adaptin
Feature Type protein coding gene
Genetic Map
Chromosome 11
3.15 cM, cytoband A2
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr11:4986824-5042729 bp, + strand
From VEGA annotation of GRCm38

  55906 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:21972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adaptor protein complex, beta subunit
Gene Tree: Ap1b1

Human Homolog AP1B1, adaptor-related protein complex 1, beta 1 subunit
NCBI Gene ID 162
neXtProt AC  NX_Q10567
Human Synonyms  ADTB1, AP105A, BAM22, CLAPB2
Human Chr (Location)  22q12.2; chr22:29327680-29388583 (-)  GRCh38
alleles, and
All mutations/alleles(19) : Gene trapped(15) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Ap1b1 interacts with 185 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
All GO classifications: (15 annotations)
Process clathrin coat assembly, intracellular protein transport, ...
Component clathrin adaptor complex, cytoplasmic vesicle, ...
Function protein binding, protein transporter activity
External Resources: FuncBase
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 21
Assay TypeResults
RNA in situ 2
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(20) Genomic(5) cDNA(14) Other(1)
Microarray probesets(3)
Other database
VEGA Gene ModelOTTMUSG00000005076 (Evidence)
Ensembl Gene ModelENSMUSG00000009090 (Evidence)
Entrez Gene11764 (Evidence)
DFCITC1573306, TC1586761, TC1673431
NIA Mouse Gene IndexU012278
Consensus CDS ProjectCCDS36100.1
International Mouse Knockout Project StatusAp1b1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005076 VEGA Gene Model | MGI Sequence Detail 55906 C57BL/6J ±  kb
transcript OTTMUST00000011327 VEGA | MGI Sequence Detail 3735 Not Applicable 
polypeptide OTTMUSP00000005282 VEGA | MGI Sequence Detail 923 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(12) UniProt(7)
Polymorphisms SNPs within 2kb(421 from dbSNP Build 137)
InterPro IPR016342 AP-1, 2,4 complex subunit beta
InterPro IPR026739 AP complex subunit beta
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR012295 Beta2-adaptin/TBP, C-terminal domain
InterPro IPR015151 Beta-adaptin appendage, C-terminal subdomain
InterPro IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
InterPro IPR013037 Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
InterPro IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
InterPro IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
Protein Ontology PR:000004090 AP-1 complex subunit beta-1
References (Earliest) J:42384 Guilbaud C, et al., Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization. Mamm Genome. 1997 Sep;8(9):651-6
(Latest) J:177015 Kang RS, et al., ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells. J Cell Biol. 2011 Apr 4;193(1):51-60
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory