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Ap1b1 Gene Detail
Summary
  • Symbol
    Ap1b1
  • Name
    adaptor protein complex AP-1, beta 1 subunit
  • Synonyms
    Adtb1, b2b1660Clo, beta-prime adaptin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096368
    NCBI Gene: 11764
  • Gene Overview
    MyGene.info: AP1B1
Location & Maps
more
  • Sequence Map
    Chr11:4986824-5042729 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55906 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.15 cM, cytoband A2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    AP1B1, adaptor related protein complex 1 beta 1 subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AP1B1, adaptor related protein complex 1 beta 1 subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADTB1, AP105A, BAM22, CLAPB2
  • Links
    NCBI Gene ID: 162
    neXtProt AC: NX_Q10567

  • Chr Location
    22q12.2; chr22:29327680-29388583 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    20 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (ENU)
    1
  • Gene trapped
    15
  • Targeted
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005076 VEGA Gene Model | MGI Sequence Detail 55906 C57BL/6J ±  kb
transcript OTTMUST00000011327 VEGA | MGI Sequence Detail 3735 Not Applicable  
polypeptide OTTMUSP00000005282 VEGA | MGI Sequence Detail 923 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    417 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000004090 AP-1 complex subunit beta-1
  • InterPro Domains
    IPR016342 AP-1, 2,4 complex subunit beta
    IPR026739 AP complex subunit beta
    IPR000225 Armadillo
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR012295 Beta2-adaptin/TBP, C-terminal domain
    IPR015151 Beta-adaptin appendage, C-terminal subdomain
    IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
    IPR013037 Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
    IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
    IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
    IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
    IPR032682 Condensin complex subunit 1, C-terminal
Molecular
Reagents
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  • All nucleic 20
    Genomic 5
    cDNA 14
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:5433318
References
more
  • Summaries
    All 46
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:42384 Guilbaud C, et al., Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization. Mamm Genome. 1997 Sep;8(9):651-6
  • Latest
    J:231949 San Agustin JT, et al., Genetic link between renal birth defects and congenital heart disease. Nat Commun. 2016;7:11103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory