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Psme1
Gene Detail
 Symbol
Name
ID
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
MGI:1096367
Synonyms PA28a
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband C2-D1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr14:55578123-55581529 bp, + strand
From VEGA annotation of GRCm38

  3407 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: proteasome activator PA28 alpha chain
Gene Tree: Psme1

Human
homologs
Human Homolog PSME1, proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
NCBI Gene ID 5720
neXtProt AC  NX_Q06323
Human Synonyms  IFI5111, PA28A, PA28alpha, REGalpha
Human Chr (Location)  14q11.2; chr14:24136158-24138967 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Psme1 interacts with 72 markers (Mir22, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process antigen processing and presentation of exogenous antigen, positive regulation of endopeptidase activity
Component extracellular vesicular exosome, proteasome activator complex, ...
Function endopeptidase activator activity, protein binding
External Resources: FuncBase
Expression
cDNA source data(153)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(156) Genomic(2) cDNA(153) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037625 (Evidence)
Ensembl Gene ModelENSMUSG00000022216 (Evidence)
Entrez Gene19186 (Evidence)
UniGene830
DFCITC1572667, TC1623579
DoTSDT.103600338, DT.536429
NIA Mouse Gene IndexU015659
Consensus CDS ProjectCCDS36931.1
International Mouse Knockout Project StatusPsme1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037625 VEGA Gene Model | MGI Sequence Detail 3407 C57BL/6J ±  kb
transcript OTTMUST00000097067 VEGA | MGI Sequence Detail 1112 Not Applicable 
polypeptide OTTMUSP00000054356 VEGA | MGI Sequence Detail 249 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(2) UniProt(7)
Polymorphisms PCR(1) : SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009077 Proteasome activator pa28, REG alpha/beta subunit
InterPro IPR003185 Proteasome activator pa28, REG alpha subunit
InterPro IPR003186 Proteasome activator pa28, REG beta subunit
Protein Ontology PR:000013392 proteasome activator complex subunit 1
References (Earliest) J:32937 Groettrup M, et al., A role for the proteasome regulator PA28alpha in antigen presentation. Nature. 1996 May 9;381(6578):166-8
(Latest) J:208595 Otoda T, et al., Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver. Diabetes. 2013 Mar;62(3):811-24
All references(53)
Other
accession IDs
MGI:2145813

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory