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Psme1 Gene Detail
Summary
  • Symbol
    Psme1
  • Name
    proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
  • Synonyms
    PA28a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096367
    NCBI Gene: 19186
  • Gene Overview
    MyGene.info: PSME1
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55578494-55581527 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C2-D1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096367
 protein coding gene Chr14:55578123-55581529 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021351
 protein coding gene Chr14:49613266-49616672 (+)
A/J MGP_AJ_G0021310
 protein coding gene Chr14:48624543-48627949 (+)
AKR/J MGP_AKRJ_G0021286
 protein coding gene Chr14:50370622-50374028 (+)
BALB/cJ MGP_BALBcJ_G0021314
 protein coding gene Chr14:48570921-48574327 (+)
C3H/HeJ MGP_C3HHeJ_G0021094
 protein coding gene Chr14:50057224-50060630 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021752
 protein coding gene Chr14:52108833-52112239 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019299
 protein coding gene Chr14:46999787-47003128 (+)
CAST/EiJ MGP_CASTEiJ_G0020613
 protein coding gene Chr14:46321813-46325257 (+)
CBA/J MGP_CBAJ_G0021061
 protein coding gene Chr14:53662978-53666384 (+)
DBA/2J MGP_DBA2J_G0021182
 protein coding gene Chr14:48350714-48354120 (+)
FVB/NJ MGP_FVBNJ_G0021164
 protein coding gene Chr14:47799264-47802673 (+)
LP/J MGP_LPJ_G0021256
 protein coding gene Chr14:50657670-50661076 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021188
 protein coding gene Chr14:53024765-53028174 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021779
 protein coding gene Chr14:49559415-49562821 (+)
PWK/PhJ MGP_PWKPhJ_G0020360
 protein coding gene Chr14:44882079-44885672 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020188
 protein coding gene Chr14:45563009-45566417 (+)
WSB/EiJ MGP_WSBEiJ_G0020666
 protein coding gene Chr14:49843059-49846468 (+)



Homology
more
  • Human Ortholog
    PSME1, proteasome activator subunit 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PSME1, proteasome activator subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-129m, IFI5111, PA28A, PA28alpha, REGalpha
  • Links
    NCBI Gene ID: 5720
    neXtProt AC: NX_Q06323
    UniProt: Q06323

  • Chr Location
    14q12; chr14:24136158-24138967 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
    154
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19186 NCBI Gene Model | MGI Sequence Detail 3034 C57BL/6J ±  kb
transcript NM_011189 RefSeq | MGI Sequence Detail 977 C57BL/6  
polypeptide P97371 UniProt | EBI | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013392 proteasome activator complex subunit 1
    (term hierarchy)
  • PDB
    5MSJ, 5MX5
  • InterPro Domains
    IPR009077 Proteasome activator PA28
    IPR003186 Proteasome activator PA28, C-terminal domain
    IPR036997 Proteasome activator PA28, C-terminal domain superfamily
    IPR003185 Proteasome activator PA28, N-terminal domain
    IPR036996 Proteasome activator PA28, N-terminal domain superfamily
    IPR036252 Proteasome activator superfamily
Molecular
Reagents
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  • All nucleic 157
    Genomic 2
    cDNA 154
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145813
References
more
  • Summaries
    All 55
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:32937 Groettrup M, et al., A role for the proteasome regulator PA28alpha in antigen presentation. Nature. 1996 May 9;381(6578):166-8
  • Latest
    J:265034 Bartelt A, et al., Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med. 2018 Mar;24(3):292-303
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/08/2019
MGI 6.14 		The Jackson Laboratory