Psme1
Gene Detail

Symbol

Name
ID

Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
MGI:1096367

Synonyms

PA28a

Feature Type

protein coding gene

Genetic Map

Chromosome 14
28.19 cM, cytoband C2-D1
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr14:55578123-55581529 bp, + strand From VEGA annotation of GRCm38   3407 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: proteasome activator PA28 alpha chain
Gene Tree: Psme1

Human
homologs

Human Homolog		PSME1, proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
NCBI Gene ID		5720
neXtProt AC		NX_Q06323
Human Synonyms		IFI5111, PA28A, PA28alpha, REGalpha
Human Chr (Location)		14q11.2; chr14:24136158-24138967 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Psme1 interacts with 72 markers (Mir22, Mir27a, Mir27b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (7 annotations)

Process	antigen processing and presentation of exogenous antigen, positive regulation of endopeptidase activity
Component	extracellular vesicular exosome, proteasome activator complex, ...
Function	endopeptidase activator activity, protein binding

External Resources: FuncBase

Expression

cDNA source data(153)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(156) Genomic(2) cDNA(153) Primer pair(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000037625 (Evidence)
Ensembl Gene Model	ENSMUSG00000022216 (Evidence)
Entrez Gene	19186 (Evidence)
UniGene	830
DFCI	TC1572667, TC1623579
DoTS	DT.103600338, DT.536429
NIA Mouse Gene Index	U015659
Consensus CDS Project	CCDS36931.1
International Mouse Knockout Project Status	Psme1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037625	VEGA Gene Model | MGI Sequence Detail	3407	C57BL/6J
transcript	OTTMUST00000097067	VEGA | MGI Sequence Detail	1112	Not Applicable
polypeptide	OTTMUSP00000054356	VEGA | MGI Sequence Detail	249	Not Applicable

All sequences(68) RefSeq(2) UniProt(7)

Polymorphisms

PCR(1) : SNPs within 2kb(42 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR009077	Proteasome activator pa28, REG alpha/beta subunit
InterPro	IPR003185	Proteasome activator pa28, REG alpha subunit
InterPro	IPR003186	Proteasome activator pa28, REG beta subunit
Protein Ontology	PR:000013392	proteasome activator complex subunit 1

References

(Earliest) J:32937 Groettrup M, et al., A role for the proteasome regulator PA28alpha in antigen presentation. Nature. 1996 May 9;381(6578):166-8
(Latest) J:208595 Otoda T, et al., Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver. Diabetes. 2013 Mar;62(3):811-24
All references(53)

Other
accession IDs

MGI:2145813