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Psme1 Gene Detail
Summary
  • Symbol
    Psme1
  • Name
    proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
  • Synonyms
    PA28a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096367
    NCBI Gene: 19186
  • Gene Overview
    MyGene.info: PSME1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr14:55578123-55581529 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      3407 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C2-D1
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    PSME1, proteasome activator subunit 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PSME1, proteasome activator subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-129m, IFI5111, PA28A, PA28alpha, REGalpha
  • Links
    NCBI Gene ID: 5720
    neXtProt AC: NX_Q06323
    UniProt: Q06323

  • Chr Location
    14q12; chr14:24136158-24138967 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    153
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037625 VEGA Gene Model | MGI Sequence Detail 3407 C57BL/6J ±  kb
transcript OTTMUST00000097067 VEGA | MGI Sequence Detail 1112 Not Applicable  
polypeptide OTTMUSP00000054356 VEGA | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    41 from dbSNP Build 142
  • PCR
    1
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013392 proteasome activator complex subunit 1
    (term hierarchy)
  • PDB
    5MSJ, 5MX5
  • InterPro Domains
    IPR009077 Proteasome activator PA28
    IPR003186 Proteasome activator PA28, C-terminal domain
    IPR036997 Proteasome activator PA28, C-terminal domain superfamily
    IPR003185 Proteasome activator PA28, N-terminal domain
    IPR036996 Proteasome activator PA28, N-terminal domain superfamily
    IPR036252 Proteasome activator superfamily
Molecular
Reagents
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  • All nucleic 156
    Genomic 2
    cDNA 153
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145813
References
more
  • Summaries
    All 51
    Gene Ontology 3
    Phenotypes 17
  • Earliest
    J:32937 Groettrup M, et al., A role for the proteasome regulator PA28alpha in antigen presentation. Nature. 1996 May 9;381(6578):166-8
  • Latest
    J:208595 Otoda T, et al., Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver. Diabetes. 2013 Mar;62(3):811-24
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory