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Psme3 Gene Detail
Summary
  • Symbol
    Psme3
  • Name
    proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
  • Synonyms
    Ki, pa28g, PA28gamma, REGgamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096366
    NCBI Gene: 19192
  • Gene Overview
    MyGene.info: PSME3
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101316251-101323531 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 64.67 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096366
protein coding gene Chr11:101316213-101323537 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019194
protein coding gene Chr11:104160727-104168054 (+)
A/J MGP_AJ_G0019162
protein coding gene Chr11:99783252-99790732 (+)
AKR/J MGP_AKRJ_G0019131
protein coding gene Chr11:102885337-102892662 (+)
BALB/cJ MGP_BALBcJ_G0019136
protein coding gene Chr11:100270156-100277476 (+)
C3H/HeJ MGP_C3HHeJ_G0018945
protein coding gene Chr11:103060496-103067823 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019585
protein coding gene Chr11:107412194-107419520 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017211
protein coding gene Chr11:97197056-97204116 (+)
CAST/EiJ MGP_CASTEiJ_G0018499
protein coding gene Chr11:104047230-104053199 (+)
CBA/J MGP_CBAJ_G0018914
protein coding gene Chr11:111849419-111856743 (+)
DBA/2J MGP_DBA2J_G0019026
protein coding gene Chr11:99312632-99319957 (+)
FVB/NJ MGP_FVBNJ_G0019016
protein coding gene Chr11:98860472-98867792 (+)
LP/J MGP_LPJ_G0019095
protein coding gene Chr11:104704436-104711837 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019047
protein coding gene Chr11:111411626-111420749 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019623
protein coding gene Chr11:103211573-103218898 (+)
PWK/PhJ MGP_PWKPhJ_G0018262
protein coding gene Chr11:100367656-100373740 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018054
protein coding gene Chr11:102948317-102955628 (+)
WSB/EiJ MGP_WSBEiJ_G0018548
protein coding gene Chr11:103208252-103215570 (+)



Homology
more
  • Human Ortholog
    PSME3, proteasome activator subunit 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PSME3, proteasome activator subunit 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-283, Ki, PA28G, PA28gamma, PA28-gamma, REG-GAMMA
  • Links
    NCBI Gene ID: 10197
    neXtProt AC: NX_P61289
    UniProt: P61289

  • Chr Location
    17q21.31; chr17:42833142-42843760 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants are smaller than normal with a defect in cell proliferation and increased susceptibility to fungal infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19192 NCBI Gene Model | MGI Sequence Detail 7281 C57BL/6J ±  kb
transcript NM_011192 RefSeq | MGI Sequence Detail 2680 Not Specified  
polypeptide P61290 UniProt | EBI | MGI Sequence Detail 254 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013394 proteasome activator complex subunit 3
  • InterPro Domains
    IPR009077 Proteasome activator PA28
    IPR003186 Proteasome activator PA28, C-terminal domain
    IPR036997 Proteasome activator PA28, C-terminal domain superfamily
    IPR003185 Proteasome activator PA28, N-terminal domain
    IPR036996 Proteasome activator PA28, N-terminal domain superfamily
    IPR036252 Proteasome activator superfamily
Molecular
Reagents
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  • All nucleic 158
    Genomic 1
    cDNA 156
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2144008, MGI:2144405
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 20
  • Earliest
    J:41183 Jiang H, et al., Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki. Immunogenetics. 1997;46(2):93-8
  • Latest
    J:244814 Sun J, et al., The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-kappaB and Important for Host Defense against Bacterial Pathogens. Cell Rep. 2016 Feb 02;14(4):737-749

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory