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Psme3 Gene Detail
Summary
  • Symbol
    Psme3
  • Name
    proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
  • Synonyms
    Ki, pa28g, PA28gamma, REGgamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096366
    NCBI Gene: 19192
  • Gene Overview
    MyGene.info: PSME3
Location & Maps
more
  • Sequence Map
    Chr11:101316213-101323537 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7325 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 64.67 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PSME3, proteasome activator subunit 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PSME3, proteasome activator subunit 3
    Orthology source: HomoloGene
  • Synonyms
    HEL-S-283, Ki, PA28G, PA28gamma, PA28-gamma, REG-GAMMA
  • Links
    NCBI Gene ID: 10197
    neXtProt AC: NX_P61289

  • Chr Location
    17q21; chr17:42833142-42843760 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Gene trapped
    16
  • Targeted
    5
  • Genomic Mutations
    1 involving Psme3
  • Incidental Mutations
Homozygous null mutants are smaller than normal with a defect in cell proliferation and increased susceptibility to fungal infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002795 VEGA Gene Model | MGI Sequence Detail 7325 C57BL/6J ±  kb
transcript OTTMUST00000005634 VEGA | MGI Sequence Detail 2664 Not Applicable  
polypeptide OTTMUSP00000002694 VEGA | MGI Sequence Detail 254 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    22 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013394 proteasome activator complex subunit 3
  • InterPro Domains
    IPR009077 Proteasome activator pa28
    IPR003186 Proteasome activator pa28, C-terminal domain
    IPR003185 Proteasome activator pa28, N-terminal domain
Molecular
Reagents
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  • All nucleic 157
    Genomic 1
    cDNA 155
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2144008, MGI:2144405
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 18
  • Earliest
    J:41183 Jiang H, et al., Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki. Immunogenetics. 1997;46(2):93-8
  • Latest
    J:222800 Li L, et al., REGgamma is critical for skin carcinogenesis by modulating the Wnt/beta-catenin pathway. Nat Commun. 2015;6:6875

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory