Psme3 MGI Mouse Gene Detail - MGI:1096366 - proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)

Symbol

Psme3
Name

proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
Synonyms

Ki, pa28g, PA28gamma, REGgamma

Feature Type

protein coding gene
IDs

MGI:1096366
NCBI Gene: 19192
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:101207039-101214363 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 64.67 cM
Mapping Data

4 experiments

SNPs within 2kb

190 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096366	protein coding gene	Chr11:101206090-101214363 (+)
129S1/SvImJ	ENSMUSG00200051119	protein coding gene	Chr11:98477521-98484849 (+)
A/J	ENSMUSG00195051556	protein coding gene	Chr11:98170749-98178269 (+)
AKR/J	ENSMUSG00220046414	protein coding gene	Chr11:98407361-98414685 (+)
BALB/cJ	ENSMUSG00180047309	protein coding gene	Chr11:98539589-98546914 (+)
C3H/HeJ	ENSMUSG00175048283	protein coding gene	Chr11:98451086-98458413 (+)
C57BL/6NJ	ENSMUSG00215052515	protein coding gene	Chr11:98027024-98034348 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017211	protein coding gene	Chr11:97197056-97204116 (+)
CAST/EiJ	ENSTCUG00005045975	protein coding gene	Chr11:97950535-97957891 (+)
CBA/J	ENSMUSG00210053048	protein coding gene	Chr11:98172836-98180160 (+)
DBA/2J	ENSMUSG00185040856	protein coding gene	Chr11:98500935-98508262 (+)
FVB/NJ	ENSMUSG00205042678	protein coding gene	Chr11:98357737-98365061 (+)
JF1/MsJ	ENSUMUG00000054739	protein coding gene	Chr11:98759259-98766655 (+)
LP/J	ENSMUSG00230050077	protein coding gene	Chr11:99553573-99560901 (+)
NOD/ShiLtJ	ENSMUSG00190036146	protein coding gene	Chr11:98539522-98546847 (+)
NZO/HlLtJ	ENSMUSG00225050550	protein coding gene	Chr11:101589433-101596760 (+)
PWK/PhJ	ENSLUMG00010039204	protein coding gene	Chr11:98308290-98315698 (+)
SPRET/EiJ	ENSMSPG00010046758	protein coding gene	Chr11:98795495-98802806 (+)
WSB/EiJ	ENSIUOG00005047942	protein coding gene	Chr11:98301769-98309092 (+)

Human Ortholog

PSME3, proteasome activator subunit 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSME3, proteasome activator subunit 3
Synonyms

HEL-S-283, Ki, PA28G, PA28-gamma, PA28gamma, REG-GAMMA
Links

HGNC:9570

NCBI Gene ID: 10197

UniProt: P61289
Chr Location

17q21.31; chr17:42824385-42843760 (+) GRCh38

MGI Vertebrate Homology

Psme3 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: PSME3
Gene Tree

Psme3

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Phenotype Summary

8 phenotypes from 4 alleles in 4 genetic backgrounds
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Endonuclease-mediated

6
Gene trapped

15
Targeted

5
Genomic Mutations

1 involving Psme3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

Homozygous null mutants are smaller than normal with a defect in cell proliferation and increased susceptibility to fungal infection. Homozygosity for a phosphoblocking or phosphomimetic allele leads to decreased and increased susceptibility to developing head and neck squamous cell carcinoma, respectively.

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All GO Annotations

34
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

33
cDNA Data

156
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PSME3

Xenbase psme3

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All Sequences

75
RefSeq

8
UniProt

5
CCDS

CCDS25463.1

Ensembl

ENSMUSG00000078652 (Evidence)
NCBI Gene

19192

			Length	Strain/Species	Flank
genomic	ENSMUSG00000078652	Ensembl Gene Model \| MGI Sequence Detail	7325	C57BL/6J	± kb
transcript	ENSMUST00000019470	Ensembl \| MGI Sequence Detail	2664	Not Applicable
polypeptide	ENSMUSP00000019470	Ensembl \| MGI Sequence Detail	254	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013394 proteasome activator complex subunit 3

(term hierarchy)
InterPro Domains

IPR009077 Proteasome activator PA28

IPR003186 Proteasome activator PA28, C-terminal domain

IPR036997 Proteasome activator PA28, C-terminal domain superfamily

IPR003185 Proteasome activator PA28, N-terminal domain

IPR036996 Proteasome activator PA28, N-terminal domain superfamily

IPR036252 Proteasome activator superfamily
GlyGen

P61290 3 sites, 1 O-linked glycan (2 sites)

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All nucleic 158

Genomic 1

cDNA 156

Primer pair 1

Microarray probesets 4

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MGI:2144008, MGI:2144405

Summaries

All 79

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 34
Earliest

J:41183 Jiang H, et al., Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki. Immunogenetics. 1997;46(2):93-8
Latest

J:378349 Sun S, et al., Phosphorylation of PA28gamma by CK2 kinase facilitates HNSCC tumor formation and progression. Nat Commun. 2025 Dec 10;17(1):443

TSS for Psme3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105075	Chr11:101207026-101207101 (+)	25 bp
Tssr105076	Chr11:101207662-101207716 (+)	650 bp
Tssr105077	Chr11:101207743-101207753 (+)	709 bp
Tssr105078	Chr11:101211549-101211563 (+)	4,517 bp
Tssr105079	Chr11:101212709-101212742 (+)	5,687 bp
Tssr105080	Chr11:101212880-101212921 (+)	5,862 bp
Tssr105081	Chr11:101212998-101213015 (+)	5,968 bp
Tssr105082	Chr11:101213398-101213417 (+)	6,369 bp
Tssr105083	Chr11:101213672-101213723 (+)	6,659 bp
Tssr105084	Chr11:101213859-101213890 (+)	6,836 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24