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Psme2
Gene Detail
Symbol

Name
ID
Psme2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
MGI:1096365
Synonyms
PA28b
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband C2-D1
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr14:55587441-55591113 bp, - strand
From VEGA annotation of GRCm38

  3673 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86889  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PSME2
Gene Tree: Psme2

Human
homologs
PSME2, proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5721
neXtProt AC: NX_Q9UL46

Human Synonyms: PA28B, PA28beta, REGbeta

Human Chr (Location): 14q11.2; chr14:24143365-24147316 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Homozygous disruption of this gene results in impaired cytotoxic T lymphocyte responses and immunoproteasome assembly.
 
Interactions
Psme2 interacts with 36 markers (Mir20a, Mir106b, Mir135a-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (20)    Tissues (8)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
RT-PCR 14
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase psme2 ; ZFIN psme2    NEW 
Molecular
reagents
All nucleic(50) Genomic(6) cDNA(41) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000034667 (Evidence)
Ensembl Gene Model ENSMUSG00000079197 (Evidence)
Entrez Gene 19188 (Evidence)
UniGene 371573
Consensus CDS Project CCDS49494.1, CCDS49495.1
International Mouse Phenotyping Consortium Status Psme2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034667 VEGA Gene Model | MGI Sequence Detail 3673 C57BL/6J ±  kb
transcript OTTMUST00000087990 VEGA | MGI Sequence Detail 962 Not Applicable 
polypeptide OTTMUSP00000047933 VEGA | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6)
Polymorphisms
PCR(1) : SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000013393 proteasome activator complex subunit 2
References
(Earliest) J:41183 Jiang H, et al., Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki. Immunogenetics. 1997;46(2):93-8
(Latest) J:208595 Otoda T, et al., Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver. Diabetes. 2013 Mar;62(3):811-24
All references(47)
Other
accession IDs
MGI:2144028, MGI:2145690

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory