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Psme2
Gene Detail
 Symbol
Name
ID
Psme2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
MGI:1096365
Synonyms PA28b
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband C2-D1
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr14:55587441-55591113 bp, - strand
From VEGA annotation of GRCm38

  3673 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86889  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Psme2

Human
homologs
Human Homolog PSME2, proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
NCBI Gene ID 5721
neXtProt AC  NX_Q9UL46
Human Synonyms  PA28B, PA28beta, REGbeta
Human Chr (Location)  14q11.2; chr14:24143365-24147316 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from APF )
 
Homozygous disruption of this gene results in impaired cytotoxic T lymphocyte responses and immunoproteasome assembly.
 
Interactions
Psme2 interacts with 36 markers (Mir20a, Mir106b, Mir135a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process antigen processing and presentation of exogenous antigen, positive regulation of endopeptidase activity
Component extracellular vesicular exosome, membrane
Function endopeptidase activator activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (20)    Tissues (8)    Images (6)
Theiler Stages: 15, 23, 28
Assay TypeResults
RNA in situ 6
RT-PCR 14
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) Genomic(6) cDNA(41) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034667 (Evidence)
Ensembl Gene ModelENSMUSG00000079197 (Evidence)
Entrez Gene19188 (Evidence)
UniGene371573
Consensus CDS ProjectCCDS49494.1, CCDS49495.1
International Mouse Knockout Project StatusPsme2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034667 VEGA Gene Model | MGI Sequence Detail 3673 C57BL/6J ±  kb
transcript OTTMUST00000087990 VEGA | MGI Sequence Detail 962 Not Applicable 
polypeptide OTTMUSP00000047933 VEGA | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6)
Polymorphisms PCR(1) : SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000013393 proteasome activator complex subunit 2
References (Earliest) J:41183 Jiang H, et al., Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki. Immunogenetics. 1997;46(2):93-8
(Latest) J:208595 Otoda T, et al., Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver. Diabetes. 2013 Mar;62(3):811-24
All references(49)
Other
accession IDs
MGI:2144028, MGI:2145690

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory