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Galr1 Gene Detail
Summary
  • Symbol
    Galr1
  • Name
    galanin receptor 1
  • Synonyms
    Galnr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096364
    NCBI Gene: 14427
  • Alliance
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr18:82410621-82424902 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 55.78 cM, cytoband E3-E4
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096364
protein coding gene Chr18:82410505-82424902 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024600
protein coding gene Chr18:83413560-83427845 (-)
A/J MGP_AJ_G0024567
protein coding gene Chr18:79771847-79786126 (-)
AKR/J MGP_AKRJ_G0024538
protein coding gene Chr18:82136849-82151130 (-)
BALB/cJ MGP_BALBcJ_G0024565
protein coding gene Chr18:79962210-79976489 (-)
C3H/HeJ MGP_C3HHeJ_G0024334
protein coding gene Chr18:82246251-82260588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025012
protein coding gene Chr18:85471648-85485928 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022443
protein coding gene Chr18:78532151-78546443 (-)
CAST/EiJ MGP_CASTEiJ_G0023807
protein coding gene Chr18:82545206-82565420 (-)
CBA/J MGP_CBAJ_G0024304
protein coding gene Chr18:88653689-88667959 (-)
DBA/2J MGP_DBA2J_G0024434
protein coding gene Chr18:79296169-79310449 (-)
FVB/NJ MGP_FVBNJ_G0024400
protein coding gene Chr18:78603540-78617892 (-)
LP/J MGP_LPJ_G0024518
protein coding gene Chr18:83236639-83250956 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024430
protein coding gene Chr18:89878186-89892441 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025061
protein coding gene Chr18:82311736-82326024 (-)
PWK/PhJ MGP_PWKPhJ_G0023552
protein coding gene Chr18:79663777-79683896 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023358
protein coding gene Chr18:82423841-82438462 (-)
WSB/EiJ MGP_WSBEiJ_G0023869
protein coding gene Chr18:82291093-82305407 (-)



Homology
more
  • Human Ortholog
    GALR1, galanin receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GALR1, galanin receptor 1
  • Synonyms
    GALNR, GALNR1
  • Links
    NCBI Gene ID: 2587
    neXtProt AC: NX_P47211
    UniProt: P47211

  • Chr Location
    18q23; chr18:77249848-77277900 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14427 NCBI Gene Model | MGI Sequence Detail 14282 C57BL/6J ±  kb
    transcript NM_008082 RefSeq | MGI Sequence Detail 2871 ZRU/MplStud  
    polypeptide P56479 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 9
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:38577 Simoneaux DK, et al., Galanin receptor gene (Galnr1) is tightly linked to the myelin basic protein gene on Chromosome 18 in mouse. Mamm Genome. 1997;8(Nov):875
    • Latest
      J:292170 Petrescu AD, et al., Coordinated Targeting of Galanin Receptors on Cholangiocytes and Hepatic Stellate Cells Ameliorates Liver Fibrosis in Multidrug Resistance Protein 2 Knockout Mice. Am J Pathol. 2020 Mar;190(3):586-601

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory