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Gp5 Gene Detail
Summary
  • Symbol
    Gp5
  • Name
    glycoprotein 5 (platelet)
  • Synonyms
    GPV, GP V
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096363
    NCBI Gene: 14729
  • Gene Overview
    MyGene.info: GP5
Location & Maps
more
  • Sequence Map
    Chr16:30307686-30310779 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3094 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 21.26 cM, cytoband B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GP5, glycoprotein V platelet
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GP5, glycoprotein V platelet
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD42d, GPV
  • Links
    NCBI Gene ID: 2814
    neXtProt AC: NX_P40197

  • Chr Location
    3q29; chr3:194394821-194399266 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 74523
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GP5
  • Gene Tree
    Gp5
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for one null allele develop normally with no spontaneous bleeding while their platelets show normal thrombin responsiveness and lack a Bernard-Soulier phenotype. In contrast, homozygotes for a second null allele show a shorter bleeding time and platelet hyperresponsiveness to thrombin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047953 Ensembl Gene Model | MGI Sequence Detail 3094 C57BL/6J ±  kb
transcript ENSMUST00000061190 Ensembl | MGI Sequence Detail 2196 Not Applicable  
polypeptide ENSMUSP00000051895 Ensembl | MGI Sequence Detail 567 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    20 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001909 platelet glycoprotein V
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 6
    Genomic 2
    cDNA 3
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:40027 Ravanat C, et al., Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. Blood. 1997 May 1;89(9):3253-62
  • Latest
    J:225923 Potts KS, et al., Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL. Blood. 2015 Aug 6;126(6):807-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory