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Gp5
Gene Detail
Symbol

Name
ID
Gp5
glycoprotein 5 (platelet)
MGI:1096363
Synonyms
GPV, GP V
Feature Type
protein coding gene
Genetic Map
Chromosome 16
21.26 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:30307686-30310779 bp, - strand
From Ensembl annotation of GRCm38

  3094 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74523  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gp5

Human
homologs
Human Homolog GP5, glycoprotein V (platelet)
NCBI Gene ID 2814
neXtProt AC  NX_P40197
Human Synonyms  CD42d, GPV
Human Chr (Location)  3q29; chr3:194394821-194399266 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for one null allele develop normally with no spontaneous bleeding while their platelets show normal thrombin responsiveness and lack a Bernard-Soulier phenotype. In contrast, homozygotes for a second null allele show a shorter bleeding time and platelet hyperresponsiveness to thrombin.
 
Interactions
Gp5 interacts with 51 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process cell-matrix adhesion, negative regulation of platelet activation
Component cell surface, extracellular vesicular exosome
Function collagen binding
External Resources: FuncBase
Expression
cDNA source data(3)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(6) Genomic(2) cDNA(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000047953 (Evidence)
Entrez Gene14729 (Evidence)
DFCITC1585576
DoTSDT.55229509
Consensus CDS ProjectCCDS28100.1
International Mouse Knockout Project StatusGp5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047953 Ensembl Gene Model | MGI Sequence Detail 3094 C57BL/6J ±  kb
transcript ENSMUST00000061190 Ensembl | MGI Sequence Detail 2196 Not Applicable 
polypeptide ENSMUSP00000051895 Ensembl | MGI Sequence Detail 567 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000001909 platelet glycoprotein V
References
(Earliest) J:40027 Ravanat C, et al., Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. Blood. 1997 May 1;89(9):3253-62
(Latest) J:168396 Cosemans JM, et al., Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow. Blood. 2011 Jan 13;117(2):651-60
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory