Cd151
Gene Detail

Symbol Name ID

Cd151 CD151 antigen MGI:1096360

Synonyms

PETA-3, SFA-1, Tspan24

Feature Type

protein coding gene

Genetic Map

Chromosome 7

86.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:141467362-141471479 bp, + strand From Ensembl annotation of GRCm38   4118 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20916  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tetraspanin
Gene Tree: Cd151

Human homologs

Human Homolog		CD151, CD151 molecule (Raph blood group)
NCBI Gene ID		977
neXtProt AC		NX_P48509
Human Synonyms		GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24
Human Chr (Location)		11p15.5; chr11:832952-838835 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CD151

Alleles and phenotypes

All alleles(27) : Targeted(5) Gene trapped(22)
 

Mice homozygous for mutations in this gene display increased bleeding time, impaired keratinocyte migration, hyperproliferation of stimulated T cells, impaired pathologic angiogenesis in several in vivo assays, and kidney abnormalities.

 
Human Diseases Modeled Using Mouse Cd151 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	cell migration, T cell proliferation
Component	integral to membrane, membrane

External Resources: FuncBase

Expression

Literature Summary: (3 records)
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(4) cDNA(11) Primer pair(5)
Microarray probesets(9)

Other database links

Ensembl Gene Model	ENSMUSG00000025510 (Evidence)
Entrez Gene	12476 (Evidence)
DFCI	TC1574271, TC1581012, TC1709383, TC1773646
Consensus CDS Project	CCDS22017.1
International Mouse Knockout Project Status	Cd151

Sequences

Length	Strain/Species
genomic	ENSMUSG00000025510	Ensembl Gene Model | MGI Sequence Detail	4118	C57BL/6J
transcript	ENSMUST00000106000	Ensembl | MGI Sequence Detail	1902	Not Applicable
polypeptide	ENSMUSP00000101622	Ensembl | MGI Sequence Detail	253	Not Applicable

All sequences(63) RefSeq(6) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000301	Tetraspanin
InterPro	IPR018503	Tetraspanin, conserved site
InterPro	IPR008952	Tetraspanin, EC2 domain
InterPro	IPR018499	Tetraspanin/Peripherin
Protein Ontology	PR:000005158	CD151 molecule

References

(Earliest) J:42363 Hasegawa H, et al., Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily. Biochim Biophys Acta. 1997 Aug 7;1353(2):125-30
(Latest) J:184730 Blumenthal A, et al., Morphology and migration of podocytes are affected by CD151 levels. Am J Physiol Renal Physiol. 2012 May;302(10):F1265-77
All references(46)