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Cd151
Gene Detail
Symbol

Name
ID
Cd151
CD151 antigen
MGI:1096360
Synonyms
PETA-3, SFA-1, Tspan24
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:141467362-141471479 bp, + strand
From Ensembl annotation of GRCm38

  4118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20916  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CD151
Protein SuperFamily: tetraspanin
Gene Tree: Cd151

Human
homologs
CD151, CD151 molecule (Raph blood group)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 977
neXtProt AC: NX_P48509

Human Synonyms: GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24

Human Chr (Location): 11p15.5; chr11:832952-838835 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CD151

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(22) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for mutations in this gene display increased bleeding time, impaired keratinocyte migration, hyperproliferation of stimulated T cells, impaired pathologic angiogenesis in several in vivo assays, and kidney abnormalities.
 
Human Diseases Modeled in Mice Using Cd151 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Cd151 interacts with 156 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell migration, T cell proliferation
Component basement membrane, focal adhesion, ...
Function integrin binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cd151 ; ZFIN cd151    NEW 
Molecular
reagents
All nucleic(20) Genomic(4) cDNA(11) Primer pair(5)
Microarray probesets(9)
Other database
links
Ensembl Gene Model ENSMUSG00000025510 (Evidence)
Entrez Gene 12476 (Evidence)
DFCI TC1581012, TC1574271, TC1773646, TC1709383
Consensus CDS Project CCDS22017.1
International Mouse Phenotyping Consortium Status Cd151
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025510 Ensembl Gene Model | MGI Sequence Detail 4118 C57BL/6J ±  kb
transcript ENSMUST00000106000 Ensembl | MGI Sequence Detail 1902 Not Applicable 
polypeptide ENSMUSP00000101622 Ensembl | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000301 Tetraspanin
InterPro IPR018503 Tetraspanin, conserved site
InterPro IPR008952 Tetraspanin, EC2 domain
InterPro IPR018499 Tetraspanin/Peripherin
Protein Ontology PR:000005158 CD151 molecule
References
(Earliest) J:42363 Hasegawa H, et al., Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily. Biochim Biophys Acta. 1997 Aug 7;1353(2):125-30
(Latest) J:218570 Delimont D, et al., Laminin alpha2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis. PLoS One. 2014;9(6):e99083
All references(55)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory