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Cd151 Gene Detail
Summary
  • Symbol
    Cd151
  • Name
    CD151 antigen
  • Synonyms
    PETA-3, SFA-1, Tspan24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096360
    NCBI Gene: 12476
  • Gene Overview
    MyGene.info: CD151
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141467392-141471473 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096360
protein coding gene Chr7:141467362-141471481 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033234
protein coding gene Chr7:146660273-146664388 (+)
A/J MGP_AJ_G0033216
protein coding gene Chr7:142465425-142469794 (+)
AKR/J MGP_AKRJ_G0033148
protein coding gene Chr7:146416375-146420491 (+)
BALB/cJ MGP_BALBcJ_G0033217
protein coding gene Chr7:142209851-142213968 (+)
C3H/HeJ MGP_C3HHeJ_G0032931
protein coding gene Chr7:146151768-146155888 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033728
protein coding gene Chr7:152011432-152015549 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030701
protein coding gene Chr7:143672653-143676767 (+)
CAST/EiJ MGP_CASTEiJ_G0032261
protein coding gene Chr7:138465760-138469880 (+)
CBA/J MGP_CBAJ_G0032903
protein coding gene Chr7:157171238-157175355 (+)
DBA/2J MGP_DBA2J_G0033055
protein coding gene Chr7:140409809-140413927 (+)
FVB/NJ MGP_FVBNJ_G0033008
protein coding gene Chr7:140324723-140328840 (+)
LP/J MGP_LPJ_G0033150
protein coding gene Chr7:148152761-148156883 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033041
protein coding gene Chr7:157805566-157809725 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033748
protein coding gene Chr7:145374173-145378290 (+)
PWK/PhJ MGP_PWKPhJ_G0031965
protein coding gene Chr7:133694940-133699049 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032372
protein coding gene Chr7:146322719-146326895 (+)



Homology
more
  • Human Ortholog
    CD151, CD151 molecule (Raph blood group)
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CD151, CD151 molecule (Raph blood group)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24
  • Links
    NCBI Gene ID: 977
    neXtProt AC: NX_P48509
    UniProt: P48509

  • Chr Location
    11p15.5; chr11:832952-838835 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 4 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in this gene display increased bleeding time, impaired keratinocyte migration, hyperproliferation of stimulated T cells, impaired pathologic angiogenesis in several in vivo assays, and kidney abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025510 Ensembl Gene Model | MGI Sequence Detail 4082 C57BL/6J ±  kb
transcript ENSMUST00000106000 Ensembl | MGI Sequence Detail 1865 Not Applicable  
polypeptide ENSMUSP00000101622 Ensembl | MGI Sequence Detail 253 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 4
    cDNA 12
    Primer pair 5

    Microarray probesets 9
References
more
  • Summaries
    All 62
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 31
  • Earliest
    J:42363 Hasegawa H, et al., Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily. Biochim Biophys Acta. 1997 Aug 7;1353(2):125-30
  • Latest
    J:253574 Naudin C, et al., Characterization of the early molecular changes in the glomeruli of Cd151 (-/-) mice highlights induction of mindin and MMP-10. Sci Rep. 2017 Nov 22;7(1):15987

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory