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Cd151
Gene Detail
 Symbol
Name
ID
Cd151
CD151 antigen
MGI:1096360
Synonyms PETA-3, SFA-1, Tspan24
Feature Type protein coding gene
Genetic Map
Chromosome 7
86.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:141467362-141471479 bp, + strand
From Ensembl annotation of GRCm38

  4118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20916  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tetraspanin
Gene Tree: Cd151

Human
homologs
Human Homolog CD151, CD151 molecule (Raph blood group)
NCBI Gene ID 977
neXtProt AC  NX_P48509
Human Synonyms  GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24
Human Chr (Location)  11p15.5; chr11:832952-838835 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD151
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(22) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for mutations in this gene display increased bleeding time, impaired keratinocyte migration, hyperproliferation of stimulated T cells, impaired pathologic angiogenesis in several in vivo assays, and kidney abnormalities.
 
Human Diseases Modeled Using Mouse Cd151 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Cd151 interacts with 157 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process cell migration, T cell proliferation
Component integral component of membrane, membrane
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(4) cDNA(11) Primer pair(5)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000025510 (Evidence)
Entrez Gene12476 (Evidence)
DFCITC1574271, TC1581012, TC1709383, TC1773646
Consensus CDS ProjectCCDS22017.1
International Mouse Knockout Project StatusCd151
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025510 Ensembl Gene Model | MGI Sequence Detail 4118 C57BL/6J ±  kb
transcript ENSMUST00000177840 Ensembl | MGI Sequence Detail 1784 Not Applicable 
polypeptide ENSMUSP00000136331 Ensembl | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000301 Tetraspanin
InterPro IPR018503 Tetraspanin, conserved site
InterPro IPR008952 Tetraspanin, EC2 domain
InterPro IPR018499 Tetraspanin/Peripherin
Protein Ontology PR:000005158 CD151 molecule
References (Earliest) J:42363 Hasegawa H, et al., Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily. Biochim Biophys Acta. 1997 Aug 7;1353(2):125-30
(Latest) J:205736 Sachs N, et al., Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151. J Invest Dermatol. 2014 Jan;134(1):221-8
All references(53)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory