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Cd151 Gene Detail
Summary
  • Symbol
    Cd151
  • Name
    CD151 antigen
  • Synonyms
    PETA-3, SFA-1, Tspan24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096360
    NCBI Gene: 12476
  • Gene Overview
    MyGene.info: CD151
Location & Maps
more
  • Sequence Map
    Chr7:141467392-141471473 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4082 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.82 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CD151, CD151 molecule (Raph blood group)
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CD151, CD151 molecule (Raph blood group)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24
  • Links
    NCBI Gene ID: 977
    neXtProt AC: NX_P48509

  • Chr Location
    11p15.5; chr11:832952-838835 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cd151 mouse models; 1 with human CD151 associations

Human Disease Mouse Models
       Nephropathy with Pretibial Epidermolysis Bullosa and Deafness   OMIM: 609057 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 4 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    3 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Gene trapped
    22
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Cd151
  • Incidental Mutations
Mice homozygous for mutations in this gene display increased bleeding time, impaired keratinocyte migration, hyperproliferation of stimulated T cells, impaired pathologic angiogenesis in several in vivo assays, and kidney abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060219 VEGA Gene Model | MGI Sequence Detail 4082 C57BL/6J ±  kb
transcript OTTMUST00000147401 VEGA | MGI Sequence Detail 1865 Not Applicable  
polypeptide OTTMUSP00000076705 VEGA | MGI Sequence Detail 253 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    42 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 4
    cDNA 11
    Primer pair 5

    Microarray probesets 9
References
more
  • Summaries
    All 56
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 30
  • Earliest
    J:42363 Hasegawa H, et al., Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily. Biochim Biophys Acta. 1997 Aug 7;1353(2):125-30
  • Latest
    J:218570 Delimont D, et al., Laminin alpha2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis. PLoS One. 2014;9(6):e99083

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory