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Cyp26a1
Gene Detail
 Symbol
Name
ID
Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
MGI:1096359
Synonyms Cyp26, MGC:13860, P450RA, P450RAI, RAH, retinoic acid hydrolase
Feature Type protein coding gene
Genetic Map
Chromosome 19
32.36 cM, cytoband C2-C3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:37697808-37701528 bp, + strand
From Ensembl annotation of GRCm38

  3721 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37349  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp26a1

Human
homologs
Human Homolog CYP26A1, cytochrome P450, family 26, subfamily A, polypeptide 1
NCBI Gene ID 1592
neXtProt AC  NX_O43174
Human Synonyms  CP26, CYP26, P450RAI, P450RAI1
Human Chr (Location)  10q23-q24; chr10:93073475-93077884 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die during mid-late gestation and exhibit spina bifida, caudal agenesis, and abnormalities of the kidneys, urogenital tract, hindgut, cervical vertebrae, and rostral hindbrain.
 
Interactions
Cyp26a1 interacts with 100 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process anterior/posterior pattern specification, central nervous system development, ...
Component endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function 1-hydroxypyrene 6,7-monooxygenase activity, 1-hydroxypyrene 7,8-monooxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (61 records)
Data Summary: Results (388)    Tissues (309)    Images (96)
Theiler Stages: 7, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 308
Northern blot 8
Western blot 5
RT-PCR 59
RNase protection 8
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(2) cDNA(23) Primer pair(10) Other(8)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024987 (Evidence)
Entrez Gene13082 (Evidence)
UniGene42230
DFCITC1585212
DoTSDT.101359564, DT.40184141
NIA Mouse Gene IndexU019416
EC1.14.-.-
Consensus CDS ProjectCCDS29780.1
International Mouse Knockout Project StatusCyp26a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024987 Ensembl Gene Model | MGI Sequence Detail 3721 C57BL/6J ±  kb
transcript ENSMUST00000025946 Ensembl | MGI Sequence Detail 1773 Not Applicable 
polypeptide ENSMUSP00000025946 Ensembl | MGI Sequence Detail 497 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002403 Cytochrome P450, E-class, group IV
Protein Ontology PR:000006107 cytochrome P450 26A1
References (Earliest) J:41831 Fujii H, et al., Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos. EMBO J. 1997 Jul 16;16(14):4163-73
(Latest) J:203823 Billings SE, et al., The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 2013 Dec;27(12):4877-89
All references(96)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory