Cyp26a1
Gene Detail

Symbol Name ID

Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 MGI:1096359

Synonyms

Cyp26, MGC:13860, P450RA, P450RAI, RAH, retinoic acid hydrolase

Feature Type

protein coding gene

Genetic Map

Chromosome 19

32.36 cM, cytoband C2-C3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr19:37697808-37701528 bp, + strand From Ensembl annotation of GRCm38   3721 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37349  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp26a1

Human homologs

Human Homolog		CYP26A1, cytochrome P450, family 26, subfamily A, polypeptide 1
NCBI Gene ID		1592
neXtProt AC		NX_O43174
Human Synonyms		CP26, CYP26, P450RAI, P450RAI1
Human Chr (Location)		10q23-q24; chr10:94833232-94837641 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for targeted null mutations die during mid-late gestation and exhibit spina bifida, caudal agenesis, and abnormalities of the kidneys, urogenital tract, hindgut, cervical vertebrae, and rostral hindbrain.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	anterior/posterior pattern specification, central nervous system development, ...
Component	endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function	electron carrier activity, heme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (56 records)
Data Summary: Results (375)    Tissues (295)    Images (90)
Theiler Stages: 7, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	295
Northern blot	8
Western blot	5
RT-PCR	59
RNase protection	8

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(2) cDNA(23) Primer pair(10) Other(7)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000024987 (Evidence)
Entrez Gene	13082 (Evidence)
UniGene	42230
DFCI	TC1585212
DoTS	DT.101359564, DT.40184141
NIA Mouse Gene Index	U019416
EC	1.14.-.-
Consensus CDS Project	CCDS29780.1
International Mouse Knockout Project Status	Cyp26a1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024987	Ensembl Gene Model | MGI Sequence Detail	3721	C57BL/6J
transcript	ENSMUST00000025946	Ensembl | MGI Sequence Detail	1773	Not Applicable
polypeptide	ENSMUSP00000025946	Ensembl | MGI Sequence Detail	497	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(57 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002403	Cytochrome P450, E-class, group IV
Protein Ontology	PR:000006107	cytochrome P450 26A1

References

(Earliest) J:41831 Fujii H, et al., Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos. EMBO J. 1997 Jul 16;16(14):4163-73
(Latest) J:190545 Boulet AM, et al., Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol. 2012 Nov 15;371(2):235-45
All references(90)