S1pr1 MGI Mouse Gene Detail - MGI:1096355 - sphingosine-1-phosphate receptor 1

S1pr1 Gene Detail

Symbol

S1pr1
Name

sphingosine-1-phosphate receptor 1
Synonyms

Edg1, S1P, S1P1

Feature Type

protein coding gene
IDs

MGI:1096355
NCBI Gene: 13609
Gene Overview

MyGene.info: S1PR1

Sequence Map

Chr3:115710433-115715072 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

4640 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 50.00 cM
Mapping Data

2 experiments

Human Ortholog

S1PR1, sphingosine-1-phosphate receptor 1

Vertebrate Orthologs

10

Human Ortholog

S1PR1, sphingosine-1-phosphate receptor 1
Orthology source: HomoloGene, HGNC
Synonyms

CD363, CHEDG1, D1S3362, ECGF1, EDG1, EDG-1, S1P1
Links

HGNC:3165

NCBI Gene ID: 1901

neXtProt AC: NX_P21453

UniProt: P21453
Chr Location

1p21.2; chr1:101236749-101241520 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1071
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: S1PR1
Protein SuperFamily

LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree

S1pr1

less

References

1 with disease annotations

less

Phenotype Summary

43 phenotypes from 6 alleles in 9 genetic backgrounds
17 phenotypes from multigenic genotypes
3 images
74 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Radiation induced

1
Targeted

12
Transgenic

1
Genomic Mutations

2 involving S1pr1
Incidental Mutations

CvDC
Find Mice (IMSR)

8 strains or lines available

Homozygotes for targeted mutations exhibit vascular defects resulting in embryonic hemorrhaging and lethality by embryonic day 14.5.

less

All GO Annotations

43
GO References

14

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

143
Tissues

87
cDNA Data

57
Literature Summary

34

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase s1pr1

ZFIN s1pr1

less

S1pr1 interacts with 247 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

less

All Sequences

26
RefSeq

2
UniProt

4
CCDS

CCDS17781.1
UniGene

982

			Length	Strain/Species	Flank
genomic	OTTMUSG00000054437	VEGA Gene Model \| MGI Sequence Detail	4640	C57BL/6J	± kb
transcript	OTTMUST00000135011	VEGA \| MGI Sequence Detail	3046	Not Applicable
polypeptide	OTTMUSP00000071529	VEGA \| MGI Sequence Detail	382	Not Applicable

less

SNPs within 2kb

57 from dbSNP Build 142

less

UniProt

4 Sequences
Protein Ontology

PR:000001706 sphingosine 1-phosphate receptor 1

(term hierarchy)
InterPro Domains

IPR000987 EDG-1 sphingosine 1-phosphate receptor

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR004061 Sphingosine 1-phosphate receptor

less

All nucleic 66

Genomic 3

cDNA 58

Primer pair 4

Other 1

Microarray probesets 4

less

MGI:2139817

Summaries

All 151

Developmental Gene Expression 34

Diseases 1

Gene Ontology 14

Phenotypes 74
Earliest

J:41657 Liu CH, et al., The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 1997 Jul 1;43(1):15-24
Latest

J:241185 Chen C, et al., Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. Mol Cell Endocrinol. 2016 May 15;427:45-56

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/13/2017 MGI 6.10