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S1pr1
Gene Detail
Symbol

Name
ID
S1pr1
sphingosine-1-phosphate receptor 1
MGI:1096355
Synonyms
Edg1, S1P, S1P1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
50.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:115710433-115715055 bp, - strand
From NCBI annotation of GRCm38

  4623 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1071  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: S1pr1

Human
homologs
Human Homolog S1PR1, sphingosine-1-phosphate receptor 1
NCBI Gene ID 1901
neXtProt AC  NX_P21453
Human Synonyms  CD363, CHEDG1, D1S3362, ECGF1, EDG1, EDG-1, S1P1
Human Chr (Location)  1p21; chr1:101236749-101241520 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
 
Homozygotes for targeted mutations exhibit vascular defects resulting in embryonic hemorrhaging and lethality by embryonic day 14.5.
 
Phenotype Images(3)
Interactions
S1pr1 interacts with 248 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (31 records)
Data Summary: Results (143)    Tissues (87)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 122
Northern blot 6
RT-PCR 15
cDNA source data(57)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) Genomic(3) cDNA(58) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000045092 (Evidence)
Entrez Gene13609 (Evidence)
UniGene982
DFCITC1775305, TC1576342
DoTSDT.531934
NIA Mouse Gene IndexU024560
Consensus CDS ProjectCCDS17781.1
International Mouse Knockout Project StatusS1pr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13609 NCBI Gene Model | MGI Sequence Detail 4623 C57BL/6J ±  kb
transcript NM_007901 RefSeq | MGI Sequence Detail 3029 C57BL/6 
polypeptide O08530 UniProt | EBI | MGI Sequence Detail 382 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000987 EDG-1 sphingosine 1-phosphate receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004061 Sphingosine 1-phosphate receptor
Protein Ontology PR:000001706 sphingosine 1-phosphate receptor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:41657 Liu CH, et al., The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 1997 Jul 1;43(1):15-24
(Latest) J:212772 Kono M, et al., Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. J Clin Invest. 2014 May 1;124(5):2076-86
All references(132)
Other
accession IDs
MGI:2139817

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory