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S1pr1 Gene Detail
Summary
  • Symbol
    S1pr1
  • Name
    sphingosine-1-phosphate receptor 1
  • Synonyms
    Edg1, S1P, S1P1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096355
    NCBI Gene: 13609
  • Gene Overview
    MyGene.info: S1PR1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr3:115710433-115715072 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      4640 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 50.00 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    S1PR1, sphingosine-1-phosphate receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    S1PR1, sphingosine-1-phosphate receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD363, CHEDG1, D1S3362, ECGF1, EDG1, EDG-1, S1P1
  • Links
    NCBI Gene ID: 1901
    neXtProt AC: NX_P21453
    UniProt: P21453

  • Chr Location
    1p21.2; chr1:101236749-101241520 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 6 alleles in 9 genetic backgrounds
    17 phenotypes from multigenic genotypes
    3 images
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    13
  • Transgenic
    1
  • Genomic Mutations
    2 involving S1pr1
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    13 strains or lines available
Homozygotes for targeted mutations exhibit vascular defects resulting in embryonic hemorrhaging and lethality by embryonic day 14.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    43
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    143
  • Tissues
    87
  • cDNA Data
    57
  • Literature Summary
    34
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054437 VEGA Gene Model | MGI Sequence Detail 4640 C57BL/6J ±  kb
transcript OTTMUST00000135011 VEGA | MGI Sequence Detail 3046 Not Applicable  
polypeptide OTTMUSP00000071529 VEGA | MGI Sequence Detail 382 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    Genomic 3
    cDNA 58
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2139817
References
more
  • Summaries
    All 153
    Developmental Gene Expression 34
    Diseases 1
    Gene Ontology 14
    Phenotypes 77
  • Earliest
    J:41657 Liu CH, et al., The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 1997 Jul 1;43(1):15-24
  • Latest
    J:242132 Yanagida K, et al., Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4531-4536
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/10/2017
MGI 6.10 		The Jackson Laboratory