S1pr1
Gene Detail

Symbol Name ID

S1pr1 sphingosine-1-phosphate receptor 1 MGI:1096355

Synonyms

Edg1, S1P, S1P1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

50.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:115710433-115715055 bp, - strand From NCBI annotation of GRCm38   4623 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1071  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: S1pr1

Human homologs

Human Homolog		S1PR1, sphingosine-1-phosphate receptor 1
NCBI Gene ID		1901
neXtProt AC		NX_P21453
Human Synonyms		CD363, CHEDG1, D1S3362, ECGF1, EDG1, EDG-1, S1P1
Human Chr (Location)		1p21; chr1:101236749-101241520 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(11) : Targeted(11)
 

Homozygotes for targeted mutations exhibit vascular defects resulting in embryonic hemorrhaging and lethality by embryonic day 14.5.

 
Phenotype Images(3)

Interactions

S1pr1 interacts with 248 markers (Mir1b, Mir7-1, Mir9-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	actin cytoskeleton reorganization, adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, ...
Component	endosome, external side of plasma membrane, ...
Function	G-protein coupled receptor activity, G-protein coupled receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (31 records)

Data Summary: Results (143)    Tissues (87)    Images (38)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	122
Northern blot	6
RT-PCR	15

cDNA source data(57)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(66) Genomic(3) cDNA(58) Primer pair(4) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000045092 (Evidence)
Entrez Gene	13609 (Evidence)
UniGene	982
DFCI	TC1576342, TC1775305
DoTS	DT.531934
NIA Mouse Gene Index	U024560
Consensus CDS Project	CCDS17781.1
International Mouse Knockout Project Status	S1pr1

Sequences

Length	Strain/Species
genomic	13609	NCBI Gene Model | MGI Sequence Detail	4623	C57BL/6J
transcript	NM_007901	RefSeq | MGI Sequence Detail	3029	C57BL/6
polypeptide	O08530	UniProt | EBI | MGI Sequence Detail	382	Not Applicable

All sequences(25) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(59 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000987	EDG-1 sphingosine 1-phosphate receptor
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR004061	Sphingosine 1-phosphate receptor
Protein Ontology	PR:000001706	sphingosine 1-phosphate receptor 1

Graphical View of Protein Domain Structure

References

(Earliest) J:41657 Liu CH, et al., The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 1997 Jul 1;43(1):15-24
(Latest) J:208200 Garris CS, et al., Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol. 2013 Nov;14(11):1166-72
All references(127)

Other accession IDs

MGI:2139817