S1pr1 MGI Mouse Gene Detail - MGI:1096355 - sphingosine-1-phosphate receptor 1

Symbol

S1pr1
Name

sphingosine-1-phosphate receptor 1
Synonyms

Edg1, S1P, S1P1

Feature Type

protein coding gene
IDs

MGI:1096355
NCBI Gene: 13609
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr3:115504082-115508704 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 50.00 cM
Mapping Data

2 experiments

SNPs within 2kb

156 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096355	protein coding gene	Chr3:115504082-115508721 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027803	protein coding gene	Chr3:117573571-117578209 (-)
A/J	MGP_AJ_G0027761	protein coding gene	Chr3:113729800-113734461 (-)
AKR/J	MGP_AKRJ_G0027727	protein coding gene	Chr3:116592849-116597512 (-)
BALB/cJ	MGP_BALBcJ_G0027773	protein coding gene	Chr3:113581289-113585954 (-)
C3H/HeJ	MGP_C3HHeJ_G0027504	protein coding gene	Chr3:116968663-116973326 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028219	protein coding gene	Chr3:121901891-121906530 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025558	protein coding gene	Chr3:109443127-109447808 (-)
CAST/EiJ	MGP_CASTEiJ_G0026960	protein coding gene	Chr3:116231943-116239146 (-)
CBA/J	MGP_CBAJ_G0027479	protein coding gene	Chr3:126057845-126062500 (-)
DBA/2J	MGP_DBA2J_G0027620	protein coding gene	Chr3:112972598-112977253 (-)
FVB/NJ	MGP_FVBNJ_G0027588	protein coding gene	Chr3:110618519-110623182 (-)
LP/J	MGP_LPJ_G0027730	protein coding gene	Chr3:119113669-119118307 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027618	protein coding gene	Chr3:133437654-133442318 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028275	protein coding gene	Chr3:116150160-116154825 (-)
PWK/PhJ	MGP_PWKPhJ_G0026686	protein coding gene	Chr3:112603667-112608303 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026508	protein coding gene	Chr3:114158127-114163476 (-)
WSB/EiJ	MGP_WSBEiJ_G0027040	protein coding gene	Chr3:116827500-116832153 (-)

Human Ortholog

S1PR1, sphingosine-1-phosphate receptor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

S1PR1, sphingosine-1-phosphate receptor 1
Synonyms

CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1
Links

HGNC:3165

NCBI Gene ID: 1901

UniProt: P21453
Chr Location

1p21.2; chr1:101236865-101243713 (+) GRCh38

MGI Vertebrate Homology

S1pr1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: S1PR1
Gene Tree

S1pr1

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References

1 with disease annotations

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Phenotype Summary

43 phenotypes from 6 alleles in 9 genetic backgrounds
8 phenotypes from multigenic genotypes
3 images
139 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

14
Genomic Mutations

2 involving S1pr1
Incidental Mutations

CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted mutations exhibit vascular defects resulting in embryonic hemorrhaging and lethality by embryonic day 14.5.

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All GO Annotations

85
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

905
Tissues

123
cDNA Data

59
Literature Summary

39

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase s1pr1

ZFIN s1pr1

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All Sequences

41
RefSeq

2
UniProt

4
CCDS

CCDS17781.1

Ensembl

ENSMUSG00000045092 (Evidence)
NCBI Gene

13609

			Length	Strain/Species	Flank
genomic	13609	NCBI Gene Model \| MGI Sequence Detail	4623	C57BL/6J	± kb
transcript	NM_007901	RefSeq \| MGI Sequence Detail	3029	C57BL/6
polypeptide	O08530	UniProt \| EBI \| MGI Sequence Detail	382	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001706 sphingosine 1-phosphate receptor 1

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR004061 Sphingosine 1-phosphate receptor

IPR000987 Sphingosine 1-phosphate receptor 1
GlyGen

O08530 3 sites, 3 N-linked glycans (3 sites)

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All nucleic 71

Genomic 3

cDNA 61

Primer pair 6

Other 1

Microarray probesets 4

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MGI:2139817

Summaries

All 264

Developmental Gene Expression 39

Diseases 1

Gene Ontology 20

Phenotypes 139
Earliest

J:41657 Liu CH, et al., The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 1997 Jul 1;43(1):15-24
Latest

J:366757 Allman A, et al., Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs. Immunity. 2025 Jan 14;58(1):143-161.e8

TSS for S1pr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35283	Chr3:115508680-115508711 (-)	8 bp
Tssr35282	Chr3:115508582-115508596 (-)	115 bp
Tssr35281	Chr3:115508538-115508568 (-)	151 bp
Tssr35280	Chr3:115508503-115508512 (-)	196 bp
Tssr35279	Chr3:115508451-115508462 (-)	247 bp
Tssr35278	Chr3:115508429-115508446 (-)	266 bp
Tssr35277	Chr3:115507442-115507455 (-)	1,255 bp
Tssr35276	Chr3:115507366-115507396 (-)	1,323 bp
Tssr35275	Chr3:115506504-115506516 (-)	2,194 bp
Tssr35274	Chr3:115506252-115506262 (-)	2,447 bp
Tssr35273	Chr3:115506188-115506203 (-)	2,508 bp
Tssr35272	Chr3:115504913-115504930 (-)	3,782 bp
Tssr35271	Chr3:115504858-115504894 (-)	3,828 bp
Tssr35270	Chr3:115504835-115504847 (-)	3,863 bp
Tssr35269	Chr3:115504823-115504834 (-)	3,875 bp
Tssr35268	Chr3:115504686-115504697 (-)	4,012 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24