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S1pr1 Gene Detail
Summary
  • Symbol
    S1pr1
  • Name
    sphingosine-1-phosphate receptor 1
  • Synonyms
    Edg1, S1P, S1P1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096355
    NCBI Gene: 13609
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:115504082-115508704 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 50.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096355
 protein coding gene Chr3:115504082-115508721 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027803
 protein coding gene Chr3:117573571-117578209 (-)
A/J MGP_AJ_G0027761
 protein coding gene Chr3:113729800-113734461 (-)
AKR/J MGP_AKRJ_G0027727
 protein coding gene Chr3:116592849-116597512 (-)
BALB/cJ MGP_BALBcJ_G0027773
 protein coding gene Chr3:113581289-113585954 (-)
C3H/HeJ MGP_C3HHeJ_G0027504
 protein coding gene Chr3:116968663-116973326 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028219
 protein coding gene Chr3:121901891-121906530 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025558
 protein coding gene Chr3:109443127-109447808 (-)
CAST/EiJ MGP_CASTEiJ_G0026960
 protein coding gene Chr3:116231943-116239146 (-)
CBA/J MGP_CBAJ_G0027479
 protein coding gene Chr3:126057845-126062500 (-)
DBA/2J MGP_DBA2J_G0027620
 protein coding gene Chr3:112972598-112977253 (-)
FVB/NJ MGP_FVBNJ_G0027588
 protein coding gene Chr3:110618519-110623182 (-)
LP/J MGP_LPJ_G0027730
 protein coding gene Chr3:119113669-119118307 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027618
 protein coding gene Chr3:133437654-133442318 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028275
 protein coding gene Chr3:116150160-116154825 (-)
PWK/PhJ MGP_PWKPhJ_G0026686
 protein coding gene Chr3:112603667-112608303 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026508
 protein coding gene Chr3:114158127-114163476 (-)
WSB/EiJ MGP_WSBEiJ_G0027040
 protein coding gene Chr3:116827500-116832153 (-)



Homology
more
  • Human Ortholog
    S1PR1, sphingosine-1-phosphate receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    S1PR1, sphingosine-1-phosphate receptor 1
  • Synonyms
    CD363, CHEDG1, D1S3362, ECGF1, EDG1, EDG-1, S1P1
  • Links
    NCBI Gene ID: 1901
    neXtProt AC: NX_P21453
    UniProt: P21453

  • Chr Location
    1p21.2; chr1:101236749-101241520 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 6 alleles in 9 genetic backgrounds
    17 phenotypes from multigenic genotypes
    3 images
    124 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit vascular defects resulting in embryonic hemorrhaging and lethality by embryonic day 14.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    901
  • Tissues
    121
  • cDNA Data
    59
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13609 NCBI Gene Model | MGI Sequence Detail 4623 C57BL/6J ±  kb
    transcript NM_007901 RefSeq | MGI Sequence Detail 3029 C57BL/6  
    polypeptide O08530 UniProt | EBI | MGI Sequence Detail 382 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 3
      cDNA 60
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139817
    References
    more
    • Summaries
      All 237
      Developmental Gene Expression 39
      Diseases 1
      Gene Ontology 15
      Phenotypes 124
    • Earliest
      J:41657 Liu CH, et al., The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 1997 Jul 1;43(1):15-24
    • Latest
      J:322588 Mork BE, et al., Sphingosine-1-phosphate receptor 1 agonist SEW2871 alters membrane properties of late-firing somatostatin expressing neurons in the central lateral amygdala. Neuropharmacology. 2022 Feb 1;203:108885
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/22/2022
    MGI 6.22     		The Jackson Laboratory