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S1pr1
Gene Detail
Symbol

Name
ID
S1pr1
sphingosine-1-phosphate receptor 1
MGI:1096355
Synonyms
Edg1, S1P, S1P1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
50.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:115710433-115715055 bp, - strand
From NCBI annotation of GRCm38

  4623 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1071  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: S1PR1
Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: S1pr1

Human
homologs
S1PR1, sphingosine-1-phosphate receptor 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1901
neXtProt AC: NX_P21453

Human Synonyms: CD363, CHEDG1, D1S3362, ECGF1, EDG1, EDG-1, S1P1

Human Chr (Location): 1p21; chr1:101236749-101241520 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from CvDC )
 
Homozygotes for targeted mutations exhibit vascular defects resulting in embryonic hemorrhaging and lethality by embryonic day 14.5.
 
Phenotype Images(3)
Interactions
S1pr1 interacts with 247 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (32 records)
Data Summary: Results (143)    Tissues (87)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 122
Northern blot 6
RT-PCR 15
cDNA source data(57)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase s1pr1 ; ZFIN s1pr1    NEW 
Molecular
reagents
All nucleic(66) Genomic(3) cDNA(58) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000045092 (Evidence)
Entrez Gene 13609 (Evidence)
UniGene 982
DFCI TC1576342, TC1775305
DoTS DT.531934
NIA Mouse Gene Index U024560
Consensus CDS Project CCDS17781.1
International Mouse Phenotyping Consortium Status S1pr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13609 NCBI Gene Model | MGI Sequence Detail 4623 C57BL/6J ±  kb
transcript NM_007901 RefSeq | MGI Sequence Detail 3029 C57BL/6 
polypeptide O08530 UniProt | EBI | MGI Sequence Detail 382 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000987 EDG-1 sphingosine 1-phosphate receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004061 Sphingosine 1-phosphate receptor
Protein Ontology PR:000001706 sphingosine 1-phosphate receptor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:41657 Liu CH, et al., The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 1997 Jul 1;43(1):15-24
(Latest) J:217596 Nakajima C, et al., The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. Development. 2014 Dec;141(23):4513-25
All references(133)
Other
accession IDs
MGI:2139817

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory