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Ptprq
Gene Detail
Symbol

Name
ID
Ptprq
protein tyrosine phosphatase, receptor type, Q
MGI:1096349
Feature Type
protein coding gene
Genetic Map
Chromosome 10
55.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:107517360-107720027 bp, - strand
From Ensembl annotation of GRCm38

  202668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:83557  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ptprq

Human
homologs
Human Homolog PTPRQ, protein tyrosine phosphatase, receptor type, Q
NCBI Gene ID 374462
Human Synonyms  DFNB84, DFNB84A, PTPGMC1, R-PTP-Q
Human Chr (Location)  12q21.2; chr12:80444346-80680189 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PTPRQ
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations show absence of shaft connectors from vestibular hair bundles, postnatal degeneration in cochlear hair-bundle structure, reduced transducer currents but otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness.
 
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (25)    Tissues (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 21
RT-PCR 4
cDNA source data(2)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(3) cDNA(2) Primer pair(3)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000035916 (Evidence)
Entrez Gene237523 (Evidence)
UniGene391418
DFCITC1630176
DoTSDT.101706118
EC3.1.3.-, 3.1.3.48
Consensus CDS ProjectCCDS36051.1
International Mouse Knockout Project StatusPtprq
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035916 Ensembl Gene Model | MGI Sequence Detail 202668 C57BL/6J ±  kb
transcript ENSMUST00000050702 Ensembl | MGI Sequence Detail 7058 Not Applicable 
polypeptide ENSMUSP00000058572 Ensembl | MGI Sequence Detail 2300 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(9) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(839 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013477 phosphotidylinositol phosphatase PTPRQ
References
(Earliest) J:22419 Hendriks W, et al., A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. Biochem J. 1995 Jan 15;305(Pt 2):499-504
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory