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Ptprq
Gene Detail
Symbol

Name
ID
Ptprq
protein tyrosine phosphatase, receptor type, Q
MGI:1096349
Feature Type
protein coding gene
Genetic Map
Chromosome 10
55.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:107517049-107720051 bp, - strand
From VEGA annotation of GRCm38

  203003 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:83557  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ptprq

Human
homologs
Human Homolog   PTPRQ, protein tyrosine phosphatase, receptor type, Q
NCBI Gene ID 374462
Human Synonyms  DFNB84, DFNB84A, PTPGMC1, R-PTP-Q
Human Chr (Location)  12q21.2; chr12:80444346-80680189 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PTPRQ
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations show absence of shaft connectors from vestibular hair bundles, postnatal degeneration in cochlear hair-bundle structure, reduced transducer currents but otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness.
 
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (25)    Tissues (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 21
RT-PCR 4
cDNA source data(2)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(3) cDNA(2) Primer pair(3)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000050771 (Evidence)
Ensembl Gene ModelENSMUSG00000035916 (Evidence)
Entrez Gene237523 (Evidence)
UniGene391418
DFCITC1630176
DoTSDT.101706118
EC3.1.3.-, 3.1.3.48
Consensus CDS ProjectCCDS36051.1
International Mouse Knockout Project StatusPtprq
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050771 VEGA Gene Model | MGI Sequence Detail 203003 C57BL/6J ±  kb
transcript OTTMUST00000128690 VEGA | MGI Sequence Detail 7393 Not Applicable 
polypeptide OTTMUSP00000069207 VEGA | MGI Sequence Detail 2300 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(7) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(839 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013477 phosphotidylinositol phosphatase PTPRQ
References
(Earliest) J:22419 Hendriks W, et al., A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. Biochem J. 1995 Jan 15;305(Pt 2):499-504
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory