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Ptprq
Gene Detail
Symbol

Name
ID
Ptprq
protein tyrosine phosphatase, receptor type, Q
MGI:1096349
Feature Type
protein coding gene
Genetic Map
Chromosome 10
55.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:107517049-107720051 bp, - strand
From VEGA annotation of GRCm38

  203003 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:83557  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PTPRQ
Gene Tree: Ptprq

Human
homologs
PTPRQ, protein tyrosine phosphatase, receptor type, Q
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 374462

Human Synonyms: DFNB84, DFNB84A, PTPGMC1, R-PTP-Q

Human Chr (Location): 12q21.2; chr12:80444274-80680189 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PTPRQ

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted mutations show absence of shaft connectors from vestibular hair bundles, postnatal degeneration in cochlear hair-bundle structure, reduced transducer currents but otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness.
 
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (25)    Tissues (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 21
RT-PCR 4
cDNA source data(2)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: ZFIN ptprq    NEW 
Molecular
reagents
All nucleic(8) Genomic(3) cDNA(2) Primer pair(3)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000050771 (Evidence)
Ensembl Gene Model ENSMUSG00000035916 (Evidence)
Entrez Gene 237523 (Evidence)
UniGene 391418
DFCI TC1630176
DoTS DT.101706118
EC 3.1.3.-, 3.1.3.48
Consensus CDS Project CCDS36051.1
International Mouse Phenotyping Consortium Status Ptprq
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050771 VEGA Gene Model | MGI Sequence Detail 203003 C57BL/6J ±  kb
transcript OTTMUST00000128690 VEGA | MGI Sequence Detail 7393 Not Applicable 
polypeptide OTTMUSP00000069207 VEGA | MGI Sequence Detail 2300 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(7) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(839 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR029021 Protein-tyrosine phosphatase-like
InterPro IPR000242 PTP type protein phosphatase
InterPro IPR000387 Tyrosine specific protein phosphatases domain
Protein Ontology PR:000013477 phosphotidylinositol phosphatase PTPRQ
References
(Earliest) J:22419 Hendriks W, et al., A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. Biochem J. 1995 Jan 15;305(Pt 2):499-504
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory