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Sema3f
Gene Detail
Symbol

Name
ID
Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
MGI:1096347
Synonyms
Sema IV, Semak
Feature Type
protein coding gene
Genetic Map
Chromosome 9
58.91 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:107681500-107710475 bp, - strand
From VEGA annotation of GRCm38

  28976 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SEMA3F
Protein SuperFamily: semaphorin
Gene Tree: Sema3f

Human
homologs
SEMA3F, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6405
neXtProt AC: NX_Q13275

Human Synonyms: SEMA4, SEMA-IV, SEMAK

Human Chr (Location): 3p21.3; chr3:50155063-50189075 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Targeted(7)
Incidental mutations (data from APF )
 
Inactivation of this locus results in neuronal defects including impaired CNS axon pathfinding, and PNS and limbic system circuitry.
 
Interactions
Sema3f interacts with 147 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process axon extension involved in axon guidance, axon guidance, ...
Component extracellular region
Function chemorepellent activity
External Resources: FuncBase
Expression
Literature Summary: (55 records)
Data Summary: Results (178)    Tissues (68)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 178
cDNA source data(69)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA SEMA3F ; Xenbase sema3f ; ZFIN sema3fa, sema3fb    NEW 
Molecular
reagents
All nucleic(72) cDNA(71) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000050787 (Evidence)
Ensembl Gene Model ENSMUSG00000034684 (Evidence)
Entrez Gene 20350 (Evidence)
UniGene 12903
DFCI TC1581263, TC1590045
DoTS DT.101317484, DT.101362246, DT.110639930, DT.485339, DT.97412117
NIA Mouse Gene Index U031322
Consensus CDS Project CCDS23505.1
International Mouse Phenotyping Consortium Status Sema3f
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050787 VEGA Gene Model | MGI Sequence Detail 28976 C57BL/6J ±  kb
transcript OTTMUST00000129015 VEGA | MGI Sequence Detail 2383 Not Applicable 
polypeptide OTTMUSP00000069357 VEGA | MGI Sequence Detail 785 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(13) UniProt(7)
Polymorphisms
SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014620 semaphorin-3F
References
(Earliest) J:49908 Chedotal A, et al., Semaphorins III and IV repel hippocampal axons via two distinct receptors. Development. 1998 Nov;125(21):4313-23
(Latest) J:221642 Klingler E, et al., The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development. Development. 2015 Jun 1;142(11):2026-36
All references(96)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory