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Sema3f
Gene Detail
Symbol

Name
ID
Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
MGI:1096347
Synonyms
Sema IV, Semak
Feature Type
protein coding gene
Genetic Map
Chromosome 9
58.91 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:107681500-107710475 bp, - strand
From Ensembl annotation of GRCm38

  28976 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema3f

Human
homologs
Human Homolog SEMA3F, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
NCBI Gene ID 6405
neXtProt AC  NX_Q13275
Human Synonyms  SEMA4, SEMA-IV, SEMAK
Human Chr (Location)  3p21.3; chr3:50155411-50189075 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from APF )
 
Inactivation of this locus results in neuronal defects including impaired CNS axon pathfinding, and PNS and limbic system circuitry.
 
Interactions
Sema3f interacts with 147 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process axon extension involved in axon guidance, axon guidance, ...
Component extracellular region, membrane
Function chemorepellent activity, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (54 records)
Data Summary: Results (178)    Tissues (68)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 178
cDNA source data(69)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(72) cDNA(71) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000034684 (Evidence)
Entrez Gene20350 (Evidence)
UniGene12903
DFCITC1581263, TC1590045
DoTSDT.485339, DT.101362246, DT.101317484, DT.110639930, DT.97412117
NIA Mouse Gene IndexU031322
Consensus CDS ProjectCCDS23505.1
International Mouse Knockout Project StatusSema3f
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034684 Ensembl Gene Model | MGI Sequence Detail 28976 C57BL/6J ±  kb
transcript ENSMUST00000192727 Ensembl | MGI Sequence Detail 2383 Not Applicable 
polypeptide ENSMUSP00000141865 Ensembl | MGI Sequence Detail 785 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014620 semaphorin-3F
References
(Earliest) J:49908 Chedotal A, et al., Semaphorins III and IV repel hippocampal axons via two distinct receptors. Development. 1998 Nov;125(21):4313-23
(Latest) J:214891 Torigoe M, et al., Role of neuropilin-2 in the ipsilateral growth of midbrain dopaminergic axons. Eur J Neurosci. 2013 May;37(10):1573-83
All references(92)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory