Sema3f
Gene Detail

Symbol Name ID

Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F MGI:1096347

Synonyms

Sema IV, Semak

Feature Type

protein coding gene

Genetic Map

Chromosome 9

58.91 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:107681502-107710475 bp, - strand From NCBI annotation of GRCm38   28974 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema3f

Human homologs

Human Homolog		SEMA3F, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
NCBI Gene ID		6405
neXtProt AC		NX_Q13275
Human Synonyms		SEMA4, SEMA-IV, SEMAK
Human Chr (Location)		3p21.3; chr3:50192848-50226508 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(6) Gene trapped(4)
 

Inactivation of this locus results in neuronal defects including impaired CNS axon pathfinding, and PNS and limbic system circuitry.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	axon guidance, multicellular organismal development, ...
Component	extracellular region, membrane
Function	chemorepellent activity, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (52 records)
Data Summary: Results (171)    Tissues (61)    Images (39)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	171

cDNA source data(69)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(71) cDNA(70) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000034684 (Evidence)
Entrez Gene	20350 (Evidence)
UniGene	12903
DFCI	TC1581263, TC1590045
DoTS	DT.101317484, DT.101362246, DT.110639930, DT.485339, DT.97412117
NIA Mouse Gene Index	U031322
Consensus CDS Project	CCDS23505.1
International Mouse Knockout Project Status	Sema3f

Sequences

Length	Strain/Species
genomic	20350	NCBI Gene Model | MGI Sequence Detail	28974	C57BL/6J
transcript	NM_011349	RefSeq | MGI Sequence Detail	3393	C57BL/6
polypeptide	O88632	UniProt | EBI | MGI Sequence Detail	785	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(74 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR027231	Semaphorin
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000014620	semaphorin-3F

Graphical View of Protein Domain Structure

References

(Earliest) J:49908 Chedotal A, et al., Semaphorins III and IV repel hippocampal axons via two distinct receptors. Development. 1998 Nov;125(21):4313-23
(Latest) J:192712 Meadows SM, et al., Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
All references(87)