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Gckr Gene Detail
Summary
  • Symbol
    Gckr
  • Name
    glucokinase regulatory protein
  • Synonyms
    GKRP, MGC:19300
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096345
    NCBI Gene: 231103
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31297443-31327314 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096345
protein coding gene Chr5:31297244-31327314 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029424
protein coding gene Chr5:29295312-29328057 (+)
A/J MGP_AJ_G0029390
protein coding gene Chr5:28329550-28361789 (+)
AKR/J MGP_AKRJ_G0029340
protein coding gene Chr5:29479782-29511405 (+)
BALB/cJ MGP_BALBcJ_G0029401
protein coding gene Chr5:28843670-28877079 (+)
C3H/HeJ MGP_C3HHeJ_G0029122
protein coding gene Chr5:29510580-29542152 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029854
protein coding gene Chr5:31104560-31138105 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027092
protein coding gene Chr5:25978752-26003335 (+)
CAST/EiJ MGP_CASTEiJ_G0028532
protein coding gene Chr5:28583892-28622561 (+)
CBA/J MGP_CBAJ_G0029090
protein coding gene Chr5:31684121-31738377 (+)
DBA/2J MGP_DBA2J_G0029239
protein coding gene Chr5:28507212-28537462 (+)
FVB/NJ MGP_FVBNJ_G0029197
protein coding gene Chr5:27923938-27954400 (+)
LP/J MGP_LPJ_G0029324
protein coding gene Chr5:29744877-29777689 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029226
protein coding gene Chr5:32544712-32580573 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029888
protein coding gene Chr5:28994909-29028430 (+)
PWK/PhJ MGP_PWKPhJ_G0028257
protein coding gene Chr5:27631226-27663826 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028088
protein coding gene Chr5:28388679-28427691 (+)
WSB/EiJ MGP_WSBEiJ_G0028613
protein coding gene Chr5:29059579-29091117 (+)



Homology
more
  • Human Ortholog
    GCKR, glucokinase regulator
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GCKR, glucokinase regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FGQTL5, GKRP
  • Links
    NCBI Gene ID: 2646
    neXtProt AC: NX_Q14397
    UniProt: Q14397

  • Chr Location
    2p23.3; chr2:27496839-27523689 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to reduced glucokinase protein levels and activity in the liver and altered glucose homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059434 Ensembl Gene Model | MGI Sequence Detail 29872 C57BL/6J ±  kb
    transcript ENSMUST00000201166 Ensembl | MGI Sequence Detail 2272 Not Applicable  
    polypeptide ENSMUSP00000144202 Ensembl | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR005486 Glucokinase regulatory protein, conserved site
      IPR001347 Sugar isomerase (SIS)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:256170 Watanabe H, et al., Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein. Nat Commun. 2018 Jan 2;9(1):30

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory