Gckr
Gene Detail

Symbol Name ID

Gckr glucokinase regulatory protein MGI:1096345

Synonyms

GKRP, MGC:19300

Feature Type

protein coding gene

Genetic Map

Chromosome 5

17.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:31297581-31327300 bp, + strand From Ensembl annotation of GRCm38   29720 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1139  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: glucokinase regulator
Gene Tree: Gckr

Human homologs

Human Homolog		GCKR, glucokinase (hexokinase 4) regulator
NCBI Gene ID		2646
neXtProt AC		NX_Q14397
Human Synonyms		FGQTL5, GKRP
Human Chr (Location)		2p23; chr2:27719706-27746551 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GCKR

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous inactivation of this gene leads to reduced glucokinase protein levels and activity in the liver and altered glucose homeostasis.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	carbohydrate metabolic process, cellular glucose homeostasis, ...
Component	nucleus
Function	carbohydrate binding, fructose-6-phosphate binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (34)    Tissues (4)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	34

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000059434 (Evidence)
Entrez Gene	231103 (Evidence)
UniGene	100043
DFCI	TC1588426
DoTS	DT.101235746, DT.91325247
NIA Mouse Gene Index	U005442
Consensus CDS Project	CCDS19182.1
International Mouse Knockout Project Status	Gckr

Sequences

Length	Strain/Species
genomic	ENSMUSG00000059434	Ensembl Gene Model | MGI Sequence Detail	29720	C57BL/6J
transcript	ENSMUST00000072228	Ensembl | MGI Sequence Detail	2012	Not Applicable
polypeptide	ENSMUSP00000072084	Ensembl | MGI Sequence Detail	587	Not Applicable

All sequences(13) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(70 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005486	Glucokinase regulatory, conserved site
InterPro	IPR001347	Sugar isomerase (SIS)
Protein Ontology	PR:000007896	glucokinase regulatory protein

References

(Earliest) J:37599 Wightman PJ, et al., The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5. Mamm Genome. 1997 Sep;8(9):700-1
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(29)