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Gckr
Gene Detail
 Symbol
Name
ID
Gckr
glucokinase regulatory protein
MGI:1096345
Synonyms GKRP, MGC:19300
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:31297581-31327300 bp, + strand
From Ensembl annotation of GRCm38

  29720 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: glucokinase regulator
Gene Tree: Gckr

Human
homologs
Human Homolog GCKR, glucokinase (hexokinase 4) regulator
NCBI Gene ID 2646
neXtProt AC  NX_Q14397
Human Synonyms  FGQTL5, GKRP
Human Chr (Location)  2p23; chr2:27496612-27523689 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Radiation induced(2) Targeted(5)
Genomic Mutations involving Gckr (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to reduced glucokinase protein levels and activity in the liver and altered glucose homeostasis.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Gckr interacts with 25 markers (Mir19a, Mir139, Mir146, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process carbohydrate metabolic process, cellular glucose homeostasis, ...
Component cell, cytoplasm, ...
Function carbohydrate binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (34)    Tissues (4)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 34
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000059434 (Evidence)
Entrez Gene231103 (Evidence)
UniGene100043
DFCITC1588426
DoTSDT.101235746, DT.91325247
NIA Mouse Gene IndexU005442
Consensus CDS ProjectCCDS19182.1
International Mouse Knockout Project StatusGckr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059434 Ensembl Gene Model | MGI Sequence Detail 29720 C57BL/6J ±  kb
transcript ENSMUST00000072228 Ensembl | MGI Sequence Detail 2012 Not Applicable 
polypeptide ENSMUSP00000072084 Ensembl | MGI Sequence Detail 587 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(8) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(111 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005486 Glucokinase regulatory, conserved site
InterPro IPR001347 Sugar isomerase (SIS)
Protein Ontology PR:000007896 glucokinase regulatory protein
References (Earliest) J:37599 Wightman PJ, et al., The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5. Mamm Genome. 1997 Sep;8(9):700-1
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory