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Gckr
Gene Detail
Symbol

Name
ID
Gckr
glucokinase regulatory protein
MGI:1096345
Synonyms
GKRP, MGC:19300
Feature Type
protein coding gene
Genetic Map
Chromosome 5
17.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:31297443-31327314 bp, + strand
From VEGA annotation of GRCm38

  29872 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GCKR
Protein SuperFamily: glucokinase regulator
Gene Tree: Gckr

Human
homologs
GCKR, glucokinase (hexokinase 4) regulator
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2646
neXtProt AC: NX_Q14397

Human Synonyms: FGQTL5, GKRP

Human Chr (Location): 2p23; chr2:27496839-27523689 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Radiation induced(3) Targeted(5)
Genomic Mutations involving Gckr (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to reduced glucokinase protein levels and activity in the liver and altered glucose homeostasis.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Gckr interacts with 25 markers (Mir19a, Mir139, Mir146, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process carbohydrate metabolic process, cellular glucose homeostasis, ...
Component cell, cytoplasm, ...
Function carbohydrate binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (34)    Tissues (4)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 34
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gckr    NEW 
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000055211 (Evidence)
Ensembl Gene Model ENSMUSG00000059434 (Evidence)
Entrez Gene 231103 (Evidence)
UniGene 100043
DFCI TC1588426
DoTS DT.101235746, DT.91325247
NIA Mouse Gene Index U005442
Consensus CDS Project CCDS19182.1
International Mouse Phenotyping Consortium Status Gckr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055211 VEGA Gene Model | MGI Sequence Detail 29872 C57BL/6J ±  kb
transcript OTTMUST00000136726 VEGA | MGI Sequence Detail 2272 Not Applicable 
polypeptide OTTMUSP00000072126 VEGA | MGI Sequence Detail 623 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(8) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(111 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005486 Glucokinase regulatory protein, conserved site
InterPro IPR001347 Sugar isomerase (SIS)
Protein Ontology PR:000007896 glucokinase regulatory protein
References
(Earliest) J:37599 Wightman PJ, et al., The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5. Mamm Genome. 1997 Sep;8(9):700-1
(Latest) J:210027 Kaminski MT, et al., Glucose-induced dissociation of glucokinase from its regulatory protein in the nucleus of hepatocytes prior to nuclear export. Biochim Biophys Acta. 2014 Mar;1843(3):554-64
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory