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Ampd3
Gene Detail
 Symbol
Name
ID
Ampd3
adenosine monophosphate deaminase 3
MGI:1096344
Feature Type protein coding gene
Genetic Map
Chromosome 7
57.85 cM, cytoband E2-E3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:110768206-110812405 bp, + strand
From VEGA annotation of GRCm38

  44200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:408  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: AMP deaminase
Gene Tree: Ampd3

Human
homologs
Human Homolog AMPD3, adenosine monophosphate deaminase 3
NCBI Gene ID 272
neXtProt AC  NX_Q01432
Human Chr (Location)  11p15; chr11:10450321-10507579 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human AMPD3
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased mean corpuscular volume, abnormal erythrocyte physiology including increased erythrocyte ATP levels and osmotic fragility after fasting, and increased lung inflammation after hind-limb ischemia and reperfusion.
 
Interactions
Ampd3 interacts with 242 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process ADP metabolic process, AMP metabolic process, ...
Component cellular_component
Function AMP deaminase activity, deaminase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (146)    Tissues (105)    Images (22)
Theiler Stages: 1, 2, 3, 5, 22, 23, 28
Assay TypeResults
RNA in situ 136
RT-PCR 10
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(7) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023504 (Evidence)
Ensembl Gene ModelENSMUSG00000005686 (Evidence)
Entrez Gene11717 (Evidence)
DFCITC1580435
DoTSDT.101341319, DT.101365102, DT.60118007
NIA Mouse Gene IndexU008634
EC3.5.4.6
Consensus CDS ProjectCCDS21747.1
International Mouse Knockout Project StatusAmpd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023504 VEGA Gene Model | MGI Sequence Detail 44200 C57BL/6J ±  kb
transcript OTTMUST00000057243 VEGA | MGI Sequence Detail 3489 Not Applicable 
polypeptide OTTMUSP00000027597 VEGA | MGI Sequence Detail 766 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(23) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(578 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006650 Adenosine/AMP deaminase active site
InterPro IPR001365 Adenosine/AMP deaminase domain
InterPro IPR006329 AMP deaminase
Protein Ontology PR:000004003 AMP deaminase 3
References (Earliest) J:39844 Wang X, et al., Cloning and expression of cDNA encoding heart-type isoform of AMP deaminase. Gene. 1997 Apr 1;188(2):285-90
(Latest) J:206035 Daniels IS, et al., AMP deaminase 3 deficiency enhanced 5'-AMP induction of hypometabolism. PLoS One. 2013;8(9):e75418
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory