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Ampd3 Gene Detail
Summary
  • Symbol
    Ampd3
  • Name
    adenosine monophosphate deaminase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096344
    NCBI Gene: 11717
  • Gene Overview
    MyGene.info: AMPD3
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:110768206-110812405 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.85 cM, cytoband E2-E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    588 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096344
protein coding gene Chr7:110767930-110812409 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032859
protein coding gene Chr7:114273093-114317006 (+)
A/J MGP_AJ_G0032843
protein coding gene Chr7:111444262-111488809 (+)
AKR/J MGP_AKRJ_G0032774
protein coding gene Chr7:114224882-114271405 (+)
BALB/cJ MGP_BALBcJ_G0032847
protein coding gene Chr7:111125443-111169681 (+)
C3H/HeJ MGP_C3HHeJ_G0032557
protein coding gene Chr7:114240091-114286998 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033353
protein coding gene Chr7:118998762-119046807 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030325
protein coding gene Chr7:113050454-113094912 (+)
CAST/EiJ MGP_CASTEiJ_G0031885
protein coding gene Chr7:105828246-105874013 (+)
CBA/J MGP_CBAJ_G0032530
protein coding gene Chr7:122885137-122934635 (+)
DBA/2J MGP_DBA2J_G0032682
protein coding gene Chr7:109527326-109572062 (+)
FVB/NJ MGP_FVBNJ_G0032635
protein coding gene Chr7:109385009-109429128 (+)
LP/J MGP_LPJ_G0032776
protein coding gene Chr7:115792895-115837056 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032667
protein coding gene Chr7:124552414-124597714 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033374
protein coding gene Chr7:113249928-113297138 (+)
PWK/PhJ MGP_PWKPhJ_G0031592
protein coding gene Chr7:102369471-102414585 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031440
protein coding gene Chr7:99997172-100041553 (+)
WSB/EiJ MGP_WSBEiJ_G0031998
protein coding gene Chr7:114104063-114149160 (+)



Homology
more
  • Human Ortholog
    AMPD3, adenosine monophosphate deaminase 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    AMPD3, adenosine monophosphate deaminase 3
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 272
    neXtProt AC: NX_Q01432
    UniProt: Q01432

  • Chr Location
    11p15.4; chr11:10450321-10507579 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased mean corpuscular volume, abnormal erythrocyte physiology including increased erythrocyte ATP levels and osmotic fragility after fasting, and increased lung inflammation after hind-limb ischemia andreperfusion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005686 Ensembl Gene Model | MGI Sequence Detail 44200 C57BL/6J ±  kb
    transcript ENSMUST00000213373 Ensembl | MGI Sequence Detail 3337 Not Applicable  
    polypeptide ENSMUSP00000149655 Ensembl | MGI Sequence Detail 775 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 7
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:250777 Hong S, et al., Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nat Med. 2017 Feb;23(2):223-234

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory