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Lhx8
Gene Detail
Symbol

Name
ID
Lhx8
LIM homeobox protein 8
MGI:1096343
Synonyms
L3, Lhx7
Feature Type
protein coding gene
Genetic Map
Chromosome 3
79.12 cM, cytoband H3-H4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:154306294-154330561 bp, - strand
From Ensembl annotation of GRCm38

  24268 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LHX8
Gene Tree: Lhx8

Human
homologs
LHX8, LIM homeobox 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 431707
neXtProt AC: NX_Q68G74

Human Synonyms: LHX7

Human Chr (Location): 1p31.1; chr1:75128434-75161533 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit partial penetrance of a cleft secondary palate and neonatal lethality; those without cleft palate survive to adulthood. All homozygous null mice have decreased or absent forebrain cholinergic neurons.
 
Phenotype Images(2)
Interactions
Lhx8 interacts with 195 markers (Mir17, Mir19b-2, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process female gonad development, forebrain neuron development, ...
Component female germ cell nucleus, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (256)    Tissues (237)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 230
RT-PCR 20
RNase protection 6
cDNA source data(24)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LHX8 ; Xenbase lhx8 ; ZFIN lhx8a    NEW 
Molecular
reagents
All nucleic(37) Genomic(5) cDNA(25) Primer pair(5) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000096225 (Evidence)
Entrez Gene 16875 (Evidence)
UniGene 15530
DFCI TC1588296, TC1641915
DoTS DT.40176479
NIA Mouse Gene Index U024784
Consensus CDS Project CCDS17926.1
International Mouse Phenotyping Consortium Status Lhx8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000096225 Ensembl Gene Model | MGI Sequence Detail 24268 C57BL/6J ±  kb
transcript ENSMUST00000177846 Ensembl | MGI Sequence Detail 1978 Not Applicable 
polypeptide ENSMUSP00000136047 Ensembl | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009796 LIM/homeobox protein Lhx8
References
(Earliest) J:31813 Matsumoto K, et al., L3, a novel murine LIM-homeodomain transcription factor expressed in the ventral telencephalon and the mesenchyme surrounding the oral cavity. Neurosci Lett. 1996 Feb 2;204(1-2):113-6
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(103)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory