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Lhx8
Gene Detail
 Symbol
Name
ID
Lhx8
LIM homeobox protein 8
MGI:1096343
Synonyms L3, Lhx7
Feature Type protein coding gene
Genetic Map
Chromosome 3
79.12 cM, cytoband H3-H4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:154306288-154330560 bp, - strand
From VEGA annotation of GRCm38

  24273 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lhx8

Human
homologs
Human Homolog LHX8, LIM homeobox 8
NCBI Gene ID 431707
neXtProt AC  NX_Q68G74
Human Synonyms  LHX7
Human Chr (Location)  1p31.1; chr1:75128434-75161533 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Homozygous null mice exhibit partial penetrance of a cleft secondary palate and neonatal lethality; those without cleft palate survive to adulthood. All homozygous null mice have decreased or absent forebrain cholinergic neurons.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process female gonad development, forebrain neuron development, ...
Component female germ cell nucleus, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (64 records)
Data Summary: Results (261)    Tissues (239)    Images (60)
Theiler Stages: 2, 3, 4, 5, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 230
RT-PCR 25
RNase protection 6
cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(37) Genomic(5) cDNA(25) Primer pair(5) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000039751 (Evidence)
Ensembl Gene ModelENSMUSG00000096225 (Evidence)
Entrez Gene16875 (Evidence)
UniGene15530
DFCITC1588296, TC1641915
DoTSDT.40176479
NIA Mouse Gene IndexU024784
Consensus CDS ProjectCCDS17926.1
International Mouse Knockout Project StatusLhx8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039751 VEGA Gene Model | MGI Sequence Detail 24273 C57BL/6J ±  kb
transcript OTTMUST00000089925 VEGA | MGI Sequence Detail 1975 Not Applicable 
polypeptide OTTMUSP00000049198 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(6)
Polymorphisms SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009796 LIM/homeobox protein Lhx8
References (Earliest) J:31813 Matsumoto K, et al., L3, a novel murine LIM-homeodomain transcription factor expressed in the ventral telencephalon and the mesenchyme surrounding the oral cavity. Neurosci Lett. 1996 Feb 2;204(1-2):113-6
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(96)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory