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Lhx8 Gene Detail
Summary
  • Symbol
    Lhx8
  • Name
    LIM homeobox protein 8
  • Synonyms
    L3, Lhx7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096343
    NCBI Gene: 16875
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:154306288-154330560 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 79.12 cM, cytoband H3-H4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096343
protein coding gene Chr3:154306288-154330659 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028002
protein coding gene Chr3:158319679-158345226 (-)
A/J MGP_AJ_G0027961
protein coding gene Chr3:152532075-152556724 (-)
AKR/J MGP_AKRJ_G0027927
protein coding gene Chr3:156617255-156641628 (-)
BALB/cJ MGP_BALBcJ_G0027973
protein coding gene Chr3:152343242-152367362 (-)
C3H/HeJ MGP_C3HHeJ_G0027703
protein coding gene Chr3:156984851-157014885 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028416
protein coding gene Chr3:163480909-163508128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025754
protein coding gene Chr3:147300378-147324217 (-)
CAST/EiJ MGP_CASTEiJ_G0027156
protein coding gene Chr3:157112279-157137780 (-)
CBA/J MGP_CBAJ_G0027678
protein coding gene Chr3:169368180-169392416 (-)
DBA/2J MGP_DBA2J_G0027818
protein coding gene Chr3:151605924-151630230 (-)
FVB/NJ MGP_FVBNJ_G0027785
protein coding gene Chr3:148983080-149007404 (-)
LP/J MGP_LPJ_G0027929
protein coding gene Chr3:159630528-159659309 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027818
protein coding gene Chr3:177807980-177835540 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028475
protein coding gene Chr3:156256175-156282509 (-)
PWK/PhJ MGP_PWKPhJ_G0026879
protein coding gene Chr3:151529635-151553798 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026707
protein coding gene Chr3:154418975-154444067 (-)
WSB/EiJ MGP_WSBEiJ_G0027236
protein coding gene Chr3:157234159-157258321 (-)



Homology
more
  • Human Ortholog
    LHX8, LIM homeobox 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LHX8, LIM homeobox 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LHX7
  • Links
    NCBI Gene ID: 431707
    neXtProt AC: NX_Q68G74
    UniProt: Q68G74

  • Chr Location
    1p31.1; chr1:75128434-75199454 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 62661
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LHX8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 4 genetic backgrounds
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit partial penetrance of a cleft secondary palate and neonatal lethality; those without cleft palate survive to adulthood. All homozygous null mice have decreased or absent forebrain cholinergic neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16875 NCBI Gene Model | MGI Sequence Detail 24273 C57BL/6J ±  kb
    transcript NM_010713 RefSeq | MGI Sequence Detail 1990 C57BL/6  
    polypeptide O35652 UniProt | EBI | MGI Sequence Detail 367 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 5
      cDNA 27
      Primer pair 5
      Other 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 89
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:31813 Matsumoto K, et al., L3, a novel murine LIM-homeodomain transcription factor expressed in the ventral telencephalon and the mesenchyme surrounding the oral cavity. Neurosci Lett. 1996 Feb 2;204(1-2):113-6
    • Latest
      J:262653 D'Ignazio L, et al., Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage. Biol Reprod. 2018 Apr 1;98(4):532-542

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/19/2019
    MGI 6.13
    The Jackson Laboratory