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Rhoa Gene Detail
Summary
  • Symbol
    Rhoa
  • Name
    ras homolog family member A
  • Synonyms
    Arha, Arha1, Arha2, RhoA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096342
    NCBI Gene: 11848
  • Gene Overview
    MyGene.info: RHOA
Location & Maps
more
  • Sequence Map
    Chr9:108306129-108337934 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31806 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.20 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RHOA, ras homolog family member A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RHOA, ras homolog family member A
    Orthology source: HomoloGene
  • Synonyms
    ARH12, ARHA, RHO12, RHOH12
  • Links
    NCBI Gene ID: 387
    neXtProt AC: NX_P61586

  • Chr Location
    3p21.3; chr3:49359136-49412093 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    231
  • Gene trapped
    220
  • Targeted
    8
  • Transgenic
    3
Mice homozygous for a conditional allele activated in neuroepithelial cells exhibit lethality during late embryonic stages associated with early cell cycle exit, premature neuronal precursor differentiation, increased apoptosis in the neural tube.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050752 VEGA Gene Model | MGI Sequence Detail 31806 C57BL/6J ±  kb
transcript OTTMUST00000128626 VEGA | MGI Sequence Detail 2197 Not Applicable  
polypeptide OTTMUSP00000069171 VEGA | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    40 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000000176 GTP-binding protein RhoA
  • PDB
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
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MGI:1355308
References
more
  • Summaries
    All 181
    Developmental Gene Expression 54
    Gene Ontology 35
    Phenotypes 35
  • Earliest
    J:87888 Ridley AJ, et al., The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992 Aug 7;70(3):389-99
  • Latest
    J:232342 Stewart K, et al., A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects. PLoS Genet. 2016 Feb;12(2):e1005785

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory