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E2f2
Gene Detail
 Symbol
Name
ID
E2f2
E2F transcription factor 2
MGI:1096341
Feature Type protein coding gene
Genetic Map
Chromosome 4
68.34 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:136172394-136196057 bp, + strand
From VEGA annotation of GRCm38

  23664 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48264  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: transcription factor E2F
Gene Tree: E2f2

Human
homologs
Human Homolog E2F2, E2F transcription factor 2
NCBI Gene ID 1870
neXtProt AC  NX_Q14209
Human Synonyms  E2F-2
Human Chr (Location)  1p36; chr1:23506428-23531220 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(17) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit premature death with signs of inflammatory and autoimmune disorders such as increased memory T cells, enlarged spleen, glomerulonephritis, inflammed liver, inflammed lung, increased double stranded DNA antibodies, hair loss, and erythema.
 
Interactions
E2f2 interacts with 282 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell cycle, intrinsic apoptotic signaling pathway by p53 class mediator, ...
Component nucleus, transcription factor complex
Function core promoter binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (180)    Tissues (171)    Images (6)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 153
Western blot 19
RT-PCR 8
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) cDNA(42) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009869 (Evidence)
Ensembl Gene ModelENSMUSG00000018983 (Evidence)
Entrez Gene242705 (Evidence)
UniGene307932
DFCITC1576866, TC1585572
DoTSDT.101340609, DT.490187, DT.55204475, DT.94333963
NIA Mouse Gene IndexU004960
Consensus CDS ProjectCCDS18801.1
International Mouse Knockout Project StatusE2f2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009869 VEGA Gene Model | MGI Sequence Detail 23664 C57BL/6J ±  kb
transcript OTTMUST00000022886 VEGA | MGI Sequence Detail 4739 Not Applicable 
polypeptide OTTMUSP00000010444 VEGA | MGI Sequence Detail 443 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(7) UniProt(4)
Polymorphisms SNPs within 2kb(294 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015633 E2F Family
InterPro IPR003316 Transcription factor E2F/dimerisation partner (TDP)
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006853 transcription factor E2F2
References (Earliest) J:125251 Karlseder J, et al., Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol. 1996 Apr;16(4):1659-67
(Latest) J:204212 Zhou J, et al., Contrasting roles of E2F2 and E2F3 in cardiac neovascularization. PLoS One. 2013;8(6):e65755
All references(95)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory