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E2f2 Gene Detail
Summary
  • Symbol
    E2f2
  • Name
    E2F transcription factor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096341
    NCBI Gene: 242705
  • Gene Overview
    MyGene.info: E2F2
Location & Maps
more
  • Sequence Map
    Chr4:136172394-136196057 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23664 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 68.34 cM, cytoband D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    E2F2, E2F transcription factor 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    E2F2, E2F transcription factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    E2F-2
  • Links
    NCBI Gene ID: 1870
    neXtProt AC: NX_Q14209

  • Chr Location
    1p36; chr1:23505974-23531250 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    2
  • Gene trapped
    17
  • Targeted
    2
  • Genomic Mutations
    3 involving E2f2
  • Incidental Mutations
Mice homozygous for a null allele exhibit premature death with signs of inflammatory and autoimmune disorders such as increased memory T cells, enlarged spleen, glomerulonephritis, inflammed liver, inflammed lung, increased double stranded DNA antibodies, hair loss, and erythema.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009869 VEGA Gene Model | MGI Sequence Detail 23664 C57BL/6J ±  kb
transcript OTTMUST00000022886 VEGA | MGI Sequence Detail 4739 Not Applicable  
polypeptide OTTMUSP00000010444 VEGA | MGI Sequence Detail 443 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    294 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006853 transcription factor E2F2
  • InterPro Domains
    IPR003316 E2F/DP family, winged-helix DNA-binding domain
    IPR015633 E2F Family
    IPR032198 E2F transcription factor, CC-MB domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 44
    cDNA 42
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 100
    Developmental Gene Expression 21
    Gene Ontology 6
    Phenotypes 47
  • Earliest
    J:125251 Karlseder J, et al., Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol. 1996 Apr;16(4):1659-67
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory