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E2f2 Gene Detail
Summary
  • Symbol
    E2f2
  • Name
    E2F transcription factor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096341
    NCBI Gene: 242705
  • Gene Overview
    MyGene.info: E2F2
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:136172394-136196057 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 68.34 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    294 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096341
protein coding gene Chr4:136172274-136196057 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028961
protein coding gene Chr4:138700135-138723856 (+)
A/J MGP_AJ_G0028920
protein coding gene Chr4:132805126-132828786 (+)
AKR/J MGP_AKRJ_G0028872
protein coding gene Chr4:136646001-136669664 (+)
BALB/cJ MGP_BALBcJ_G0028944
protein coding gene Chr4:133467450-133491149 (+)
C3H/HeJ MGP_C3HHeJ_G0028658
protein coding gene Chr4:136921863-136945522 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029385
protein coding gene Chr4:143622593-143646190 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026656
protein coding gene Chr4:125839645-125864253 (+)
CAST/EiJ MGP_CASTEiJ_G0028090
protein coding gene Chr4:135061532-135086720 (+)
CBA/J MGP_CBAJ_G0028623
protein coding gene Chr4:147553922-147579665 (+)
DBA/2J MGP_DBA2J_G0028772
protein coding gene Chr4:133222794-133246674 (+)
FVB/NJ MGP_FVBNJ_G0028739
protein coding gene Chr4:132163576-132189709 (+)
LP/J MGP_LPJ_G0028871
protein coding gene Chr4:138789717-138813487 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028765
protein coding gene Chr4:151801166-151824994 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029423
protein coding gene Chr4:137100638-137124313 (+)
PWK/PhJ MGP_PWKPhJ_G0027810
protein coding gene Chr4:129996587-130020429 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027636
protein coding gene Chr4:132919209-132944623 (+)
WSB/EiJ MGP_WSBEiJ_G0028168
protein coding gene Chr4:137271493-137295146 (+)



Homology
more
  • Human Ortholog
    E2F2, E2F transcription factor 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    E2F2, E2F transcription factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E2F-2
  • Links
    NCBI Gene ID: 1870
    neXtProt AC: NX_Q14209
    UniProt: Q14209

  • Chr Location
    1p36.12; chr1:23505696-23531266 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit premature death with signs of inflammatory and autoimmune disorders such as increased memory T cells, enlarged spleen, glomerulonephritis, inflammed liver, inflammed lung, increased double stranded DNA antibodies, hair loss, and erythema.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018983 Ensembl Gene Model | MGI Sequence Detail 23664 C57BL/6J ±  kb
    transcript ENSMUST00000061721 Ensembl | MGI Sequence Detail 4739 Not Applicable  
    polypeptide ENSMUSP00000050047 Ensembl | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 44
      Primer pair 3
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 116
      Developmental Gene Expression 22
      Gene Ontology 8
      Phenotypes 49
    • Earliest
      J:125251 Karlseder J, et al., Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol. 1996 Apr;16(4):1659-67
    • Latest
      J:261069 To B, et al., Transcription factor compensation during mammary gland development in E2F knockout mice. PLoS One. 2018;13(4):e0194937

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory