About   Help   FAQ
Ephb6 Gene Detail
Summary
  • Symbol
    Ephb6
  • Name
    Eph receptor B6
  • Synonyms
    Cekl, Mep
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096338
    NCBI Gene: 13848
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41582416-41597443 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 19.77 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096338
 protein coding gene Chr6:41581940-41597445 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030630
 protein coding gene Chr6:40119931-40134958 (+)
A/J MGP_AJ_G0030603
 protein coding gene Chr6:38374544-38389571 (+)
AKR/J MGP_AKRJ_G0030528
 protein coding gene Chr6:39618232-39633259 (+)
BALB/cJ MGP_BALBcJ_G0030613
 protein coding gene Chr6:38580136-38595168 (+)
C3H/HeJ MGP_C3HHeJ_G0030326
 protein coding gene Chr6:39639627-39654735 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031067
 protein coding gene Chr6:41132686-41147713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028274
 protein coding gene Chr6:36147719-36162723 (+)
CAST/EiJ MGP_CASTEiJ_G0029730
 protein coding gene Chr6:39446630-39461651 (+)
CBA/J MGP_CBAJ_G0030302
 protein coding gene Chr6:42840306-42855333 (+)
DBA/2J MGP_DBA2J_G0030446
 protein coding gene Chr6:38203079-38218106 (+)
FVB/NJ MGP_FVBNJ_G0030402
 protein coding gene Chr6:37925107-37940121 (+)
LP/J MGP_LPJ_G0030534
 protein coding gene Chr6:40123212-40138234 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030436
 protein coding gene Chr6:45071545-45086569 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031097
 protein coding gene Chr6:39586572-39601599 (+)
PWK/PhJ MGP_PWKPhJ_G0029442
 protein coding gene Chr6:37821760-37836920 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029279
 protein coding gene Chr6:39201543-39216544 (+)
WSB/EiJ MGP_WSBEiJ_G0029806
 protein coding gene Chr6:39500451-39515510 (+)



Homology
more
  • Human Ortholog
    EPHB6, EPH receptor B6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHB6, EPH receptor B6
  • Synonyms
    HEP
  • Links
    NCBI Gene ID: 2051
    neXtProt AC: NX_O15197
    UniProt: O15197

  • Chr Location
    7q34; chr7:142855061-142871094 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
T cell responses such as lymphokine secretion, proliferation, and the development of delayed-type skin hypersensitivity and experimental autoimmune encephalitis were compromised in homozygous null mutants.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    987
  • Tissues
    166
  • cDNA Data
    47
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029869 Ensembl Gene Model | MGI Sequence Detail 15028 C57BL/6J ±  kb
    transcript ENSMUST00000114732 Ensembl | MGI Sequence Detail 3762 Not Applicable  
    polypeptide ENSMUSP00000110380 Ensembl | MGI Sequence Detail 1014 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007133 ephrin type-B receptor 6
      (term hierarchy)
    • InterPro Domains
      IPR001090 Ephrin receptor ligand binding domain
      IPR027936 Ephrin receptor, transmembrane domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 47
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37488, MGI:108444
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 24
      Gene Ontology 4
      Phenotypes 26
    • Earliest
      J:34909 Gurniak CB, et al., A new member of the Eph family of receptors that lacks protein tyrosine kinase activity. Oncogene. 1996 Aug 15;13(4):777-86
    • Latest
      J:343437 Yu H, et al., EphB6 deficiency in intestinal neurons promotes tumor growth in colorectal cancer by neurotransmitter GABA signaling. Carcinogenesis. 2023 Dec 2;44(8-9):682-694
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory