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Ephb6 Gene Detail
Summary
  • Symbol
    Ephb6
  • Name
    Eph receptor B6
  • Synonyms
    Cekl, Mep
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096338
    NCBI Gene: 13848
Location & Maps
more
  • Sequence Map
    Chr6:41605482-41620509 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15028 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    EPHB6, EPH receptor B6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    EPHB6, EPH receptor B6
    Orthology source: HomoloGene
  • Synonyms
    HEP
  • Links
    NCBI Gene ID: 2051
    neXtProt AC: NX_O15197

  • Chr Location
    7q33-q35; chr7:142854643-142871093 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Targeted
    11
  • Genomic Mutations
    3 involving Ephb6
  • Incidental Mutations
T cell responses such as lymphokine secretion, proliferation, and the development of delayed-type skin hypersensitivity and experimental autoimmune encephalitis were compromised in homozygous null mutants.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035976 VEGA Gene Model | MGI Sequence Detail 15028 C57BL/6J ±  kb
transcript OTTMUST00000092313 VEGA | MGI Sequence Detail 3762 Not Applicable  
polypeptide OTTMUSP00000050988 VEGA | MGI Sequence Detail 1014 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    37 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007133 ephrin type-B receptor 6
  • InterPro Domains
    IPR001090 Ephrin receptor ligand binding domain
    IPR027936 Ephrin receptor, transmembrane domain
    IPR016257 Ephrin receptor type-A /type-B
    IPR003961 Fibronectin type III
    IPR008979 Galactose-binding domain-like
    IPR013783 Immunoglobulin-like fold
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
    IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Molecular
Reagents
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  • All nucleic 51
    cDNA 46
    Primer pair 5

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-37488, MGI:108444
References
more
  • Summaries
    All 56
    Developmental Gene Expression 20
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:34909 Gurniak CB, et al., A new member of the Eph family of receptors that lacks protein tyrosine kinase activity. Oncogene. 1996 Aug 15;13(4):777-86
  • Latest
    J:208050 Huang TN, et al., Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Nat Neurosci. 2014 Feb;17(2):240-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory