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Ephb6
Gene Detail
 Symbol
Name
ID
Ephb6
Eph receptor B6
MGI:1096338
Synonyms Cekl, Mep
Feature Type protein coding gene
Genetic Map
Chromosome 6
19.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:41605482-41620509 bp, + strand
From VEGA annotation of GRCm38

  15028 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Ephb6

Human
homologs
Human Homolog EPHB6, EPH receptor B6
NCBI Gene ID 2051
neXtProt AC  NX_O15197
Human Synonyms  HEP
Human Chr (Location)  7q33-q35; chr7:142855014-142871093 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
T cell responses such as lymphokine secretion, proliferation, and the development of delayed-type skin hypersensitivity and experimental autoimmune encephalitis were compromised in homozygous null mutants.
 
Phenotype Images(1)
Interactions
Ephb6 interacts with 43 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process calcium ion homeostasis, ephrin receptor signaling pathway, ...
Component cell, extracellular region, ...
Function ATP binding, ephrin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (272)    Tissues (161)    Images (70)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 261
RT-PCR 11
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(46) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035976 (Evidence)
Ensembl Gene ModelENSMUSG00000029869 (Evidence)
Entrez Gene13848 (Evidence)
UniGene271976
DFCITC1579152, TC1693058
DoTSDT.101353031, DT.529600
NIA Mouse Gene IndexU006738
Consensus CDS ProjectCCDS20051.1
International Mouse Knockout Project StatusEphb6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035976 VEGA Gene Model | MGI Sequence Detail 15028 C57BL/6J ±  kb
transcript OTTMUST00000092313 VEGA | MGI Sequence Detail 3762 Not Applicable 
polypeptide OTTMUSP00000050988 VEGA | MGI Sequence Detail 1014 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(7) UniProt(3)
Polymorphisms SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007133 ephrin type-B receptor 6
References (Earliest) J:34909 Gurniak CB, et al., A new member of the Eph family of receptors that lacks protein tyrosine kinase activity. Oncogene. 1996 Aug 15;13(4):777-86
(Latest) J:192782 Woudenberg-Vrenken TE, et al., Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption. Am J Physiol Gastrointest Liver Physiol. 2012 Oct;303(7):G879-85
All references(61)
Other
accession IDs
MGD-MRK-37488, MGI:108444

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory