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Ephb1
Gene Detail
Symbol

Name
ID
Ephb1
Eph receptor B1
MGI:1096337
Synonyms
C130099E04Rik, Cek6, Elk, Elkh, Hek6, Net
Feature Type
protein coding gene
Genetic Map
Chromosome 9
54.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:101922128-102354693 bp, - strand
From VEGA annotation of GRCm38

  432566 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20936  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Ephb1

Human
homologs
Human Homolog EPHB1, EPH receptor B1
NCBI Gene ID 2047
neXtProt AC  NX_P54762
Human Synonyms  ELK, EPHT2, Hek6, NET
Human Chr (Location)  3q21-q23; chr3:134795257-135260467 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene display marked reductions of the ipsilateral optic tract.
 
Interactions
Ephb1 interacts with 225 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (64 annotations)
Process angiogenesis, axon guidance, ...
Component axon, cell projection, ...
Function ATP binding, axon guidance receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (61 records)
Data Summary: Results (308)    Tissues (199)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 284
In situ reporter (knock in) 9
Western blot 3
RT-PCR 12
cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(61) cDNA(57) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021086 (Evidence)
Ensembl Gene ModelENSMUSG00000032537 (Evidence)
Entrez Gene270190 (Evidence)
UniGene22897
DFCITC1580302, TC1630250
DoTSDT.101129946, DT.101711920, DT.101736331, DT.55131308
NIA Mouse Gene IndexU031251
EC2.7.10.1
Consensus CDS ProjectCCDS40742.1, CCDS52901.1
International Mouse Knockout Project StatusEphb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021086 VEGA Gene Model | MGI Sequence Detail 432566 C57BL/6J ±  kb
transcript OTTMUST00000049888 VEGA | MGI Sequence Detail 4667 Not Applicable 
polypeptide OTTMUSP00000023194 VEGA | MGI Sequence Detail 984 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(4064 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007129 ephrin type-B receptor 1
References
(Earliest) J:23894 Mori T, et al., Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse. Brain Res Mol Brain Res. 1995 Apr;29(2):325-35
(Latest) J:206566 Robichaux MA, et al., EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2188-93
All references(124)
Other
accession IDs
MGD-MRK-32154, MGI:105114, MGI:2143306, MGI:3712490

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory