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Ephb1
Gene Detail
Symbol

Name
ID
Ephb1
Eph receptor B1
MGI:1096337
Synonyms
C130099E04Rik, Cek6, Elk, Elkh, Hek6, Net
Feature Type
protein coding gene
Genetic Map
Chromosome 9
54.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:101922128-102354693 bp, - strand
From VEGA annotation of GRCm38

  432566 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20936  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EPHB1
Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Ephb1

Human
homologs
EPHB1, EPH receptor B1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2047
neXtProt AC: NX_P54762

Human Synonyms: ELK, EPHT2, Hek6, NET

Human Chr (Location): 3q21-q23; chr3:134795257-135260467 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions of this gene display marked reductions of the ipsilateral optic tract.
 
Interactions
Ephb1 interacts with 224 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process angiogenesis, axon guidance, ...
Component axon, cytoplasm, ...
Function axon guidance receptor activity, protein complex binding, ...
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (309)    Tissues (199)    Images (72)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 284
In situ reporter (knock in) 9
Western blot 3
RT-PCR 12
cDNA source data(54)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ephb1    NEW 
Molecular
reagents
All nucleic(61) cDNA(57) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021086 (Evidence)
Ensembl Gene Model ENSMUSG00000032537 (Evidence)
Entrez Gene 270190 (Evidence)
UniGene 22897
DFCI TC1580302, TC1630250
DoTS DT.101129946, DT.101711920, DT.101736331, DT.55131308
NIA Mouse Gene Index U031251
Consensus CDS Project CCDS40742.1, CCDS52901.1
International Mouse Phenotyping Consortium Status Ephb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021086 VEGA Gene Model | MGI Sequence Detail 432566 C57BL/6J ±  kb
transcript OTTMUST00000049888 VEGA | MGI Sequence Detail 4667 Not Applicable 
polypeptide OTTMUSP00000023194 VEGA | MGI Sequence Detail 984 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4)
Polymorphisms
SNPs within 2kb(4064 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000007129 ephrin type-B receptor 1
References
(Earliest) J:23894 Mori T, et al., Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse. Brain Res Mol Brain Res. 1995 Apr;29(2):325-35
(Latest) J:222557 Villar-Cervino V, et al., Molecular Mechanisms Controlling the Migration of Striatal Interneurons. J Neurosci. 2015 Jun 10;35(23):8718-29
All references(124)
Other
accession IDs
MGD-MRK-32154, MGI:105114, MGI:2143306, MGI:3712490

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory