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Slc1a6
Gene Detail
 Symbol
Name
ID
Slc1a6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
MGI:1096331
Synonyms EAAT4
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:78780496-78814825 bp, + strand
From NCBI annotation of GRCm38

  34330 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21055  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glutamate/aspartate transport protein
Gene Tree: Slc1a6

Human
homologs
Human Homolog SLC1A6, solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
NCBI Gene ID 6511
neXtProt AC  NX_P48664
Human Synonyms  EAAT4
Human Chr (Location)  19p13.12; chr19:14950033-15010643 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene survive well and display no obvious abnormalities of behavior or brain structure.
 
Interactions
Slc1a6 interacts with 36 markers (Mir147, Mir297-1, Mir297a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process anion transport, dicarboxylic acid transport, ...
Component Golgi apparatus, integral component of membrane, ...
Function anion transmembrane transporter activity, L-glutamate transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (55)    Tissues (31)    Images (23)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 55
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(10) cDNA(8) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000005357 (Evidence)
Entrez Gene20513 (Evidence)
UniGene6257
DFCITC1586954
DoTSDT.55261241
NIA Mouse Gene IndexU011704
Consensus CDS ProjectCCDS23970.1
International Mouse Knockout Project StatusSlc1a6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20513 NCBI Gene Model | MGI Sequence Detail 34330 C57BL/6J ±  kb
transcript NM_009200 RefSeq | MGI Sequence Detail 2089 C57BL/6 
polypeptide O35544 UniProt | EBI | MGI Sequence Detail 561 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001991 Sodium:dicarboxylate symporter
InterPro IPR018107 Sodium:dicarboxylate symporter, conserved site
Protein Ontology PR:000014977 excitatory amino acid transporter 4
Graphical View of Protein Domain Structure
References (Earliest) J:40093 Yamada K, et al., Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells. Neurosci Res. 1997 Mar;27(3):191-8
(Latest) J:198011 Eom T, et al., NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife. 2013;2:e00178
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory