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Slc1a6
Gene Detail
Symbol

Name
ID
Slc1a6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
MGI:1096331
Synonyms
EAAT4
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:78780496-78814825 bp, + strand
From NCBI annotation of GRCm38

  34330 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21055  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC1A6
Protein SuperFamily: glutamate/aspartate transport protein
Gene Tree: Slc1a6

Human
homologs
SLC1A6, solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6511
neXtProt AC: NX_P48664

Human Synonyms: EAAT4

Human Chr (Location): 19p13.12; chr19:14950033-15010643 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene survive well and display no obvious abnormalities of behavior or brain structure.
 
Interactions
Slc1a6 interacts with 36 markers (Mir147, Mir297-1, Mir297a-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (55)    Tissues (31)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
cDNA source data(8)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100494506 ; ZFIN slc1a6    NEW 
Molecular
reagents
All nucleic(21) Genomic(10) cDNA(8) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000005357 (Evidence)
Entrez Gene 20513 (Evidence)
UniGene 6257
DFCI TC1586954
DoTS DT.55261241
NIA Mouse Gene Index U011704
Consensus CDS Project CCDS23970.1
International Mouse Phenotyping Consortium Status Slc1a6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20513 NCBI Gene Model | MGI Sequence Detail 34330 C57BL/6J ±  kb
transcript NM_009200 RefSeq | MGI Sequence Detail 2089 C57BL/6 
polypeptide O35544 UniProt | EBI | MGI Sequence Detail 561 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001991 Sodium:dicarboxylate symporter
InterPro IPR018107 Sodium:dicarboxylate symporter, conserved site
Protein Ontology PR:000014977 excitatory amino acid transporter 4
Graphical View of Protein Domain Structure
References
(Earliest) J:40093 Yamada K, et al., Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells. Neurosci Res. 1997 Mar;27(3):191-8
(Latest) J:208769 Nakatani T, et al., The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells. Dev Biol. 2014 Apr 1;388(1):68-80
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory