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Slc1a6 Gene Detail
Summary
  • Symbol
    Slc1a6
  • Name
    solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
  • Synonyms
    EAAT4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096331
    NCBI Gene: 20513
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:78780496-78814765 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096331
protein coding gene Chr10:78780496-78814825 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017430
protein coding gene Chr10:79245928-79274874 (+)
A/J MGP_AJ_G0017408
protein coding gene Chr10:76496386-76524310 (+)
AKR/J MGP_AKRJ_G0017371
protein coding gene Chr10:78540344-78567857 (+)
BALB/cJ MGP_BALBcJ_G0017370
protein coding gene Chr10:76653597-76687141 (+)
C3H/HeJ MGP_C3HHeJ_G0017193
protein coding gene Chr10:78648835-78676744 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017826
protein coding gene Chr10:82035562-82065463 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015517
protein coding gene Chr10:72793992-72848078 (+)
CAST/EiJ MGP_CASTEiJ_G0016763
protein coding gene Chr10:78948361-78977997 (+)
CBA/J MGP_CBAJ_G0017165
protein coding gene Chr10:85169815-85203662 (+)
DBA/2J MGP_DBA2J_G0017273
protein coding gene Chr10:75720158-75748103 (+)
FVB/NJ MGP_FVBNJ_G0017265
protein coding gene Chr10:74898880-74933088 (+)
LP/J MGP_LPJ_G0017344
protein coding gene Chr10:79701328-79729784 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017292
protein coding gene Chr10:87141357-87168832 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017868
protein coding gene Chr10:78583637-78622016 (+)
PWK/PhJ MGP_PWKPhJ_G0016545
protein coding gene Chr10:75610546-75640872 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016330
protein coding gene Chr10:77783499-77817649 (+)
WSB/EiJ MGP_WSBEiJ_G0016823
protein coding gene Chr10:78572363-78601852 (+)



Homology
more
  • Human Ortholog
    SLC1A6, solute carrier family 1 member 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC1A6, solute carrier family 1 member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EAAT4
  • Links
    NCBI Gene ID: 6511
    neXtProt AC: NX_P48664
    UniProt: P48664

  • Chr Location
    19p13.12; chr19:14950033-15010643 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene survive well and display no obvious abnormalities of behavior or brain structure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005357 Ensembl Gene Model | MGI Sequence Detail 34270 C57BL/6J ±  kb
transcript ENSMUST00000005490 Ensembl | MGI Sequence Detail 2029 Not Applicable  
polypeptide ENSMUSP00000005490 Ensembl | MGI Sequence Detail 561 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 10
    cDNA 8
    Primer pair 1
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 47
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:238650 Perkins EM, et al., Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of beta-III spectrin and GLAST. Hum Mol Genet. 2016 Oct 15;25(20):4448-4461

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory