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Bad Gene Detail
Summary
  • Symbol
    Bad
  • Name
    BCL2-associated agonist of cell death
  • Synonyms
    Bbc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096330
    NCBI Gene: 12015
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:6941861-6951898 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10038 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.10 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BAD, BCL2 associated agonist of cell death
  • Vertebrate Orthologs
    7
  • Human Ortholog
    BAD, BCL2 associated agonist of cell death
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BBC2, BCL2L8
  • Links
    NCBI Gene ID: 572
    neXtProt AC: NX_Q92934
    UniProt: Q92934

  • Chr Location
    11q13.1; chr11:64269828-64284704 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 5 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are grossly normal and fertile. Both T and B cells show increased sensitivity to gamma irradiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016347 VEGA Gene Model | MGI Sequence Detail 10038 C57BL/6J ±  kb
    transcript OTTMUST00000039298 VEGA | MGI Sequence Detail 1451 Not Applicable  
    polypeptide OTTMUSP00000017561 VEGA | MGI Sequence Detail 204 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      47 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 65
      Primer pair 4
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147509
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 21
      Gene Ontology 32
      Phenotypes 30
    • Earliest
      J:42326 Yang E, et al., Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 1995 Jan 27;80(2):285-91
    • Latest
      J:254911 Martinez-Francois JR, et al., BAD and KATP channels regulate neuron excitability and epileptiform activity. Elife. 2018 Jan 25;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory