About   Help   FAQ
Bad Gene Detail
Summary
  • Symbol
    Bad
  • Name
    BCL2-associated agonist of cell death
  • Synonyms
    Bbc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096330
    NCBI Gene: 12015
Location & Maps
more
  • Sequence Map
    Chr19:6941861-6951898 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10038 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.10 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BAD, BCL2 associated agonist of cell death
  • Vertebrate Orthologs
    7
  • Human Ortholog
    BAD, BCL2 associated agonist of cell death
    Orthology source: HomoloGene
  • Synonyms
    BBC2, BCL2L8
  • Links
    NCBI Gene ID: 572
    neXtProt AC: NX_Q92934

  • Chr Location
    11q13.1; chr11:64269828-64284704 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 5 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Gene trapped
    21
  • Targeted
    8
Mice homozygous for disruptions in this gene are grossly normal and fertile. Both T and B cells show increased sensitivity to gamma irradiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016347 VEGA Gene Model | MGI Sequence Detail 10038 C57BL/6J ±  kb
transcript OTTMUST00000039298 VEGA | MGI Sequence Detail 1451 Not Applicable  
polypeptide OTTMUSP00000017561 VEGA | MGI Sequence Detail 204 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    47 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000002184 Bcl2 antagonist of cell death
  • PDB
  • InterPro Domains
    IPR018868 Bcl2-associated agonist of cell death
Molecular
Reagents
less
  • All nucleic 70
    cDNA 65
    Primer pair 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147509
References
more
  • Summaries
    All 104
    Developmental Gene Expression 18
    Gene Ontology 28
    Phenotypes 29
  • Earliest
    J:42326 Yang E, et al., Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 1995 Jan 27;80(2):285-91
  • Latest
    J:210651 Gimenez-Cassina A, et al., Regulation of hepatic energy metabolism and gluconeogenesis by BAD. Cell Metab. 2014 Feb 4;19(2):272-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory