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Bad
Gene Detail
 Symbol
Name
ID
Bad
BCL2-associated agonist of cell death
MGI:1096330
Synonyms Bbc2
Feature Type protein coding gene
Genetic Map
Chromosome 19
5.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:6941861-6951898 bp, + strand
From VEGA annotation of GRCm38

  10038 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Bcl2 antagonist of cell death (BAD)
Gene Tree: Bad

Human
homologs
Human Homolog BAD, BCL2-associated agonist of cell death
NCBI Gene ID 572
neXtProt AC  NX_Q92934
Human Synonyms  BBC2, BCL2L8
Human Chr (Location)  11q13.1; chr11:64269828-64284704 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(21) Targeted(7)
 
Mice homozygous for disruptions in this gene are grossly normal and fertile. Both T and B cells show increased sensitivity to gamma irradiation.
 
Interactions
Bad interacts with 44 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, ...
Component cytoplasm, cytosol, ...
Function cysteine-type endopeptidase activator activity involved in apoptotic process, lipid binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (84)    Tissues (61)    Images (6)
Theiler Stages: 1, 2, 3, 4, 14, 15, 18, 21, 23, 25, 28
Assay TypeResults
Northern blot 18
Western blot 6
RT-PCR 55
RNase protection 5
cDNA source data(63)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) cDNA(65) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016347 (Evidence)
Ensembl Gene ModelENSMUSG00000024959 (Evidence)
Entrez Gene12015 (Evidence)
UniGene4387
DFCITC1576188, TC1602714
DoTSDT.101148594, DT.97340043, DT.97391302
NIA Mouse Gene IndexU018993
PDB2BZW
Consensus CDS ProjectCCDS29513.1, CCDS70924.1
International Mouse Knockout Project StatusBad
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016347 VEGA Gene Model | MGI Sequence Detail 10038 C57BL/6J ±  kb
transcript OTTMUST00000039298 VEGA | MGI Sequence Detail 1451 Not Applicable 
polypeptide OTTMUSP00000017561 VEGA | MGI Sequence Detail 204 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018868 Pro-apoptotic Bcl-2 protein, BAD
Protein Ontology PR:000002184 Bcl2 antagonist of cell death
References (Earliest) J:42326 Yang E, et al., Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 1995 Jan 27;80(2):285-91
(Latest) J:210651 Gimenez-Cassina A, et al., Regulation of hepatic energy metabolism and gluconeogenesis by BAD. Cell Metab. 2014 Feb 4;19(2):272-84
All references(105)
Other
accession IDs
MGI:2147509

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory