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Bad
Gene Detail
Symbol

Name
ID
Bad
BCL2-associated agonist of cell death
MGI:1096330
Synonyms
Bbc2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:6941861-6951898 bp, + strand
From VEGA annotation of GRCm38

  10038 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: BAD
Protein SuperFamily: Bcl2 antagonist of cell death (BAD)
Gene Tree: Bad

Human
homologs
BAD, BCL2-associated agonist of cell death
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 572
neXtProt AC: NX_Q92934

Human Synonyms: BBC2, BCL2L8

Human Chr (Location): 11q13.1; chr11:64269828-64284704 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(21) Targeted(7)
 
Mice homozygous for disruptions in this gene are grossly normal and fertile. Both T and B cells show increased sensitivity to gamma irradiation.
 
Interactions
Bad interacts with 44 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Expression
Literature Summary: (18 records)
Data Summary: Results (84)    Tissues (61)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 18
Western blot 6
RT-PCR 55
RNase protection 5
cDNA source data(63)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN badb    NEW 
Molecular
reagents
All nucleic(70) cDNA(65) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016347 (Evidence)
Ensembl Gene Model ENSMUSG00000024959 (Evidence)
Entrez Gene 12015 (Evidence)
UniGene 4387
DFCI TC1576188, TC1602714
DoTS DT.101148594, DT.97340043, DT.97391302
NIA Mouse Gene Index U018993
PDB 2BZW
Consensus CDS Project CCDS29513.1, CCDS70924.1
International Mouse Phenotyping Consortium Status Bad
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016347 VEGA Gene Model | MGI Sequence Detail 10038 C57BL/6J ±  kb
transcript OTTMUST00000039298 VEGA | MGI Sequence Detail 1451 Not Applicable 
polypeptide OTTMUSP00000017561 VEGA | MGI Sequence Detail 204 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018868 Pro-apoptotic Bcl-2 protein, BAD
Protein Ontology PR:000002184 Bcl2 antagonist of cell death
References
(Earliest) J:42326 Yang E, et al., Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 1995 Jan 27;80(2):285-91
(Latest) J:210651 Gimenez-Cassina A, et al., Regulation of hepatic energy metabolism and gluconeogenesis by BAD. Cell Metab. 2014 Feb 4;19(2):272-84
All references(105)
Other
accession IDs
MGI:2147509

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory