Bad
Gene Detail

Symbol Name ID

Bad BCL2-associated agonist of cell death MGI:1096330

Synonyms

Bbc2

Feature Type

protein coding gene

Genetic Map

Chromosome 19

5.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:6941861-6951898 bp, + strand From VEGA annotation of GRCm38   10038 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Bcl2 antagonist of cell death (BAD)
Gene Tree: Bad

Human homologs

Human Homolog		BAD, BCL2-associated agonist of cell death
NCBI Gene ID		572
neXtProt AC		NX_Q92934
Human Synonyms		BBC2, BCL2L8
Human Chr (Location)		11q13.1; chr11:64037300-64052176 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(26) : Targeted(5) Gene trapped(21)
 

Mice homozygous for disruptions in this gene are grossly normal and fertile. Both T and B cells show increased sensitivity to gamma irradiation.

 

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, ...
Component	cytoplasm, cytosol, ...
Function	cysteine-type endopeptidase activator activity involved in apoptotic process, lipid binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (97)    Tissues (63)    Images (6)
Theiler Stages: 1, 2, 3, 4, 14, 15, 18, 21, 23, 25, 28

Assay Type	Results
Northern blot	31
Western blot	6
RT-PCR	55
RNase protection	5

cDNA source data(63)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(70) cDNA(65) Primer pair(4) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016347 (Evidence)
Ensembl Gene Model	ENSMUSG00000024959 (Evidence)
Entrez Gene	12015 (Evidence)
UniGene	4387
DFCI	TC1576188, TC1602714
DoTS	DT.101148594, DT.97340043, DT.97391302
NIA Mouse Gene Index	U018993
PDB	2BZW
Consensus CDS Project	CCDS29513.1
International Mouse Knockout Project Status	Bad

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016347	VEGA Gene Model | MGI Sequence Detail	10038	C57BL/6J
transcript	OTTMUST00000039298	VEGA | MGI Sequence Detail	1451	Not Applicable
polypeptide	OTTMUSP00000017561	VEGA | MGI Sequence Detail	204	Not Applicable

All sequences(46) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(39 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018868	Pro-apoptotic Bcl-2 protein, BAD
Protein Ontology	PR:000002184	Bcl2 antagonist of cell death

References

(Earliest) J:42326 Yang E, et al., Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 1995 Jan 27;80(2):285-91
(Latest) J:194485 Hassan S, et al., Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013 Jan 25;
All references(99)

Other accession IDs

MGI:2147509