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Dnase1l1 Gene Detail
Summary
  • Symbol
    Dnase1l1
  • Name
    deoxyribonuclease 1-like 1
  • Synonyms
    2310005K03Rik, Dnase1ll, Dnl1ll, G4.8
  • Feature Type
    protein coding gene
  • IDs
    MGI:109628
    NCBI Gene: 69537
  • Gene Overview
    MyGene.info: DNASE1L1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74273217-74282333 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    49 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109628
protein coding gene ChrX:74273217-74282337 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035837
protein coding gene ChrX:70068035-70080076 (-)
A/J MGP_AJ_G0035818
protein coding gene ChrX:70255523-70266333 (-)
AKR/J MGP_AKRJ_G0035743
protein coding gene ChrX:72155498-72168101 (-)
BALB/cJ MGP_BALBcJ_G0035803
protein coding gene ChrX:69282556-69291641 (-)
C3H/HeJ MGP_C3HHeJ_G0035508
protein coding gene ChrX:70545999-70555979 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036333
protein coding gene ChrX:72230821-72241547 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033177
protein coding gene ChrX:69319800-69331959 (-)
CAST/EiJ MGP_CASTEiJ_G0034799
protein coding gene ChrX:55923115-55935526 (-)
CBA/J MGP_CBAJ_G0035483
protein coding gene ChrX:74225050-74236124 (-)
DBA/2J MGP_DBA2J_G0035640
protein coding gene ChrX:69713396-69725865 (-)
FVB/NJ MGP_FVBNJ_G0035584
protein coding gene ChrX:69060381-69069340 (-)
LP/J MGP_LPJ_G0035725
protein coding gene ChrX:70851163-70861044 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035622
protein coding gene ChrX:76793000-76802126 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036355
protein coding gene ChrX:69888446-69898329 (-)
PWK/PhJ MGP_PWKPhJ_G0034498
protein coding gene ChrX:53887987-53897256 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034332
protein coding gene ChrX:56796833-56805897 (-)
WSB/EiJ MGP_WSBEiJ_G0034940
protein coding gene ChrX:69171832-69180928 (-)



Homology
more
  • Human Ortholog
    DNASE1L1, deoxyribonuclease 1 like 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DNASE1L1, deoxyribonuclease 1 like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DNAS1L1, DNASEX, DNL1L, G4.8, XIB
  • Links
    NCBI Gene ID: 1774
    neXtProt AC: NX_P49184
    UniProt: P49184

  • Chr Location
    Xq28; chrX:154401236-154412101 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Female mice homozygous for an inactivating mutation of this gene exhibit poor motor coordination on the rotarod even on days 4 and 5 of a 5-day test.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69537 NCBI Gene Model | MGI Sequence Detail 9117 C57BL/6J ±  kb
transcript NM_027109 RefSeq | MGI Sequence Detail 1635 C57BL/6  
polypeptide Q9D7J6 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    Genomic 4
    cDNA 33

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-35852, MGD-MRK-39627, MGI:107385, MGI:1916787, MGI:2147876
References
more
  • Summaries
    All 34
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:26634 Rivella S, et al., A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes. Genomics. 1995 Aug 10;28(3):377-82
  • Latest
    J:246602 Mohan Kumar D, et al., Ehrlichia chaffeensis uses its surface protein EtpE to bind GPI-anchored protein DNase X and trigger entry into mammalian cells. PLoS Pathog. 2013;9(10):e1003666

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory