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Dnase1l1 Gene Detail
Summary
  • Symbol
    Dnase1l1
  • Name
    deoxyribonuclease 1-like 1
  • Synonyms
    2310005K03Rik, Dnase1ll, Dnl1ll, G4.8
  • Feature Type
    protein coding gene
  • IDs
    MGI:109628
    NCBI Gene: 69537
  • Gene Overview
    MyGene.info: DNASE1L1
Location & Maps
more
  • Sequence Map
    ChrX:74273217-74282337 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9121 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.94 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DNASE1L1, deoxyribonuclease 1 like 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DNASE1L1, deoxyribonuclease 1 like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DNAS1L1, DNASEX, DNL1L, G4.8, XIB
  • Links
    NCBI Gene ID: 1774
    neXtProt AC: NX_P49184

  • Chr Location
    Xq28; chrX:154401236-154412091 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Gene trapped
    2
  • Targeted
    1
Female mice homozygous for an inactivating mutation of this gene exhibit poor motor coordination on the rotarod even on days 4 and 5 of a 5-day test.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017644 VEGA Gene Model | MGI Sequence Detail 9121 C57BL/6J ±  kb
transcript OTTMUST00000042842 VEGA | MGI Sequence Detail 1625 Not Applicable  
polypeptide OTTMUSP00000019231 VEGA | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    49 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    Genomic 4
    cDNA 32

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35852, MGD-MRK-39627, MGI:107385, MGI:1916787, MGI:2147876
References
more
  • Summaries
    All 32
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:26634 Rivella S, et al., A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes. Genomics. 1995 Aug 10;28(3):377-82
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory