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Neurog2 Gene Detail
Summary
  • Symbol
    Neurog2
  • Name
    neurogenin 2
  • Synonyms
    Atoh4, bHLHa8, Math4A, ngn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109619
    NCBI Gene: 11924
  • Gene Overview
    MyGene.info: NEUROG2
Location & Maps
more
  • Sequence Map
    Chr3:127633135-127635631 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2497 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 56.54 cM, cytoband H1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NEUROG2, neurogenin 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NEUROG2, neurogenin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Atoh4, bHLHa8, Math4A, ngn-2, NGN2
  • Links
    NCBI Gene ID: 63973
    neXtProt AC: NX_Q9H2A3
    UniProt: Q9H2A3

  • Chr Location
    4q25; chr4:112513516-112516172 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 7 alleles in 6 genetic backgrounds
    24 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    10
  • Genomic Mutations
    2 involving Neurog2
  • Find Mice (IMSR)
Homozygous null mice die after birth and have neuronal differentiation defects, affecting retinal development, spinal cord interneuron development and behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022648 VEGA Gene Model | MGI Sequence Detail 2497 C57BL/6J ±  kb
transcript OTTMUST00000054266 VEGA | MGI Sequence Detail 2227 Not Applicable  
polypeptide OTTMUSP00000025881 VEGA | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    24 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    Genomic 2
    cDNA 31
    Primer pair 4
    Other 21

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39618
References
more
  • Summaries
    All 394
    Developmental Gene Expression 339
    Diseases 1
    Gene Ontology 16
    Phenotypes 73
  • Earliest
    J:37090 Gradwohl G, et al., Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors. Dev Biol. 1996 Nov 25;180(1):227-41
  • Latest
    J:241012 Lee M, et al., Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity. Dev Biol. 2017 Apr 01;424(1):62-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory