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Neurog2 Gene Detail
Summary
  • Symbol
    Neurog2
  • Name
    neurogenin 2
  • Synonyms
    Atoh4, bHLHa8, Math4A, ngn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109619
    NCBI Gene: 11924
  • Gene Overview
    MyGene.info: NEUROG2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:127633145-127635631 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 56.54 cM, cytoband H1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109619
protein coding gene Chr3:127633135-127635631 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027863
protein coding gene Chr3:130137877-130140372 (+)
A/J MGP_AJ_G0027821
protein coding gene Chr3:125683067-125685562 (+)
AKR/J MGP_AKRJ_G0027786
protein coding gene Chr3:128929803-128932299 (+)
BALB/cJ MGP_BALBcJ_G0027834
protein coding gene Chr3:125542901-125545396 (+)
C3H/HeJ MGP_C3HHeJ_G0027563
protein coding gene Chr3:129312739-129315234 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028278
protein coding gene Chr3:134832681-134835177 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025616
protein coding gene Chr3:120929275-120931770 (+)
CAST/EiJ MGP_CASTEiJ_G0027020
protein coding gene Chr3:128867266-128904976 (+)
CBA/J MGP_CBAJ_G0027539
protein coding gene Chr3:139392889-139395384 (+)
DBA/2J MGP_DBA2J_G0027680
protein coding gene Chr3:124898763-124901266 (+)
FVB/NJ MGP_FVBNJ_G0027647
protein coding gene Chr3:122464570-122467066 (+)
LP/J MGP_LPJ_G0027789
protein coding gene Chr3:131684150-131686645 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027678
protein coding gene Chr3:147311224-147313726 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028335
protein coding gene Chr3:128562818-128565314 (+)
PWK/PhJ MGP_PWKPhJ_G0026744
protein coding gene Chr3:124631366-124661892 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026569
protein coding gene Chr3:126648744-126681731 (+)
WSB/EiJ MGP_WSBEiJ_G0027099
protein coding gene Chr3:129288961-129292089 (+)



Homology
more
  • Human Ortholog
    NEUROG2, neurogenin 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NEUROG2, neurogenin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Atoh4, bHLHa8, Math4A, ngn-2, NGN2
  • Links
    NCBI Gene ID: 63973
    neXtProt AC: NX_Q9H2A3
    UniProt: Q9H2A3

  • Chr Location
    4q25; chr4:112513516-112516172 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 7 alleles in 6 genetic backgrounds
    27 phenotypes from multigenic genotypes
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice die after birth and have neuronal differentiation defects, affecting retinal development, spinal cord interneuron development and behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11924 NCBI Gene Model | MGI Sequence Detail 2487 C57BL/6J ±  kb
    transcript NM_009718 RefSeq | MGI Sequence Detail 2253 C57BL/6  
    polypeptide P70447 UniProt | EBI | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR032655 Neurogenin-2
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 2
      cDNA 33
      Primer pair 5
      Other 23

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39618
    References
    more
    • Summaries
      All 434
      Developmental Gene Expression 367
      Diseases 1
      Gene Ontology 16
      Phenotypes 86
    • Earliest
      J:37090 Gradwohl G, et al., Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors. Dev Biol. 1996 Nov 25;180(1):227-41
    • Latest
      J:266268 Kowalchuk AM, et al., Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis. Dev Biol. 2018 Oct 15;442(2):220-235

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory