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Mia Gene Detail
Summary
  • Symbol
    Mia
  • Name
    melanoma inhibitory activity
  • Synonyms
    Cdrap, Mia1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109615
    NCBI Gene: 12587
  • Gene Overview
    MyGene.info: MIA
Location & Maps
more
  • Sequence Map
    Chr7:27179744-27181157 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1414 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 15.84 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MIA, melanoma inhibitory activity
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MIA, melanoma inhibitory activity
    Orthology source: HomoloGene
  • Synonyms
    CD-RAP
  • Links
    NCBI Gene ID: 8190
    neXtProt AC: NX_Q16674

  • Chr Location
    19q13.2; chr19:40775177-40777493 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
Mice homozygous for a targeted null mutation are viable and fertile but display alterations in the fibrillar ultrastructure of cartilage as well as minor changes in the number and morphology of chondrocytic microvilli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027206 VEGA Gene Model | MGI Sequence Detail 1414 C57BL/6J ±  kb
transcript OTTMUST00000067273 VEGA | MGI Sequence Detail 572 Not Applicable  
polypeptide OTTMUSP00000033819 VEGA | MGI Sequence Detail 131 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    47 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010393 melanoma-derived growth regulatory protein
  • InterPro Domains
    IPR001452 SH3 domain
    IPR011511 Variant SH3 domain
Molecular
Reagents
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  • All nucleic 27
    Genomic 1
    cDNA 25
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39614
References
more
  • Summaries
    All 36
    Developmental Gene Expression 13
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:43389 Blesch A, et al., Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. Cancer Res. 1994 Nov 1;54(21):5695-701
  • Latest
    J:213873 Chen Z, et al., FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Development. 2014 Jul;141(13):2691-701

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory