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Matn2 Gene Detail
Summary
  • Symbol
    Matn2
  • Name
    matrilin 2
  • Synonyms
    Crtm2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109613
    NCBI Gene: 17181
  • Gene Overview
    MyGene.info: MATN2
Location & Maps
more
  • Sequence Map
    Chr15:34306680-34436242 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      129563 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 13.98 cM, cytoband B3.3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MATN2, matrilin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MATN2, matrilin 2
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 4147
    neXtProt AC: NX_O00339

  • Chr Location
    8q22; chr8:97869056-98036720 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Gene trapped
    5
  • Targeted
    1
  • Genomic Mutations
    2 involving Matn2
  • Incidental Mutations
Homozygous null mice are healthy and fertile with no obvious abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022324 Ensembl Gene Model | MGI Sequence Detail 129563 C57BL/6J ±  kb
transcript ENSMUST00000163455 Ensembl | MGI Sequence Detail 3577 Not Applicable  
polypeptide ENSMUSP00000128202 Ensembl | MGI Sequence Detail 957 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1434 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000010206 matrilin-2
  • InterPro Domains
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR019466 Matrilin, coiled-coil trimerisation domain
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
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  • All nucleic 36
    cDNA 36

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-39612
References
more
  • Summaries
    All 40
    Developmental Gene Expression 12
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:39463 Deak F, et al., Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily. J Biol Chem. 1997 Apr 4;272(14):9268-74
  • Latest
    J:217696 Jonas A, et al., Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation. J Clin Invest. 2014 Nov;124(11):5042-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory