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Matn2 Gene Detail
Summary
  • Symbol
    Matn2
  • Name
    matrilin 2
  • Synonyms
    Crtm2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109613
    NCBI Gene: 17181
  • Gene Overview
    MyGene.info: MATN2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:34306654-34436242 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 13.98 cM, cytoband B3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1434 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109613
protein coding gene Chr15:34306654-34436273 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021777
protein coding gene Chr15:32599003-32740181 (+)
A/J MGP_AJ_G0021738
protein coding gene Chr15:31357668-31497132 (+)
AKR/J MGP_AKRJ_G0021715
protein coding gene Chr15:32208407-32355682 (+)
BALB/cJ MGP_BALBcJ_G0021744
protein coding gene Chr15:31367127-31507848 (+)
C3H/HeJ MGP_C3HHeJ_G0021519
protein coding gene Chr15:32182128-32325944 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022183
protein coding gene Chr15:33849730-33992242 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019721
protein coding gene Chr15:29249910-29386371 (+)
CAST/EiJ MGP_CASTEiJ_G0021035
protein coding gene Chr15:32594385-32734147 (+)
CBA/J MGP_CBAJ_G0021488
protein coding gene Chr15:34895737-35055308 (+)
DBA/2J MGP_DBA2J_G0021612
protein coding gene Chr15:31164728-31295549 (+)
FVB/NJ MGP_FVBNJ_G0021590
protein coding gene Chr15:30618318-30757821 (+)
LP/J MGP_LPJ_G0021681
protein coding gene Chr15:32495152-32641225 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021615
protein coding gene Chr15:37927516-38072841 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022206
protein coding gene Chr15:32395801-32529219 (+)
PWK/PhJ MGP_PWKPhJ_G0020779
protein coding gene Chr15:31205355-31344948 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020617
protein coding gene Chr15:32081351-32223940 (+)
WSB/EiJ MGP_WSBEiJ_G0021091
protein coding gene Chr15:32370805-32506194 (+)



Homology
more
  • Human Ortholog
    MATN2, matrilin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MATN2, matrilin 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4147
    neXtProt AC: NX_O00339
    UniProt: O00339

  • Chr Location
    8q22.1-q22.2; chr8:97869021-98036720 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Homozygous null mice are healthy and fertile with no obvious abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17181 NCBI Gene Model | MGI Sequence Detail 129589 C57BL/6J ±  kb
transcript NM_001358780 RefSeq | MGI Sequence Detail 3577 C57BL/6  
polypeptide O08746 UniProt | EBI | MGI Sequence Detail 956 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR030747 Matrilin-2
    IPR036337 Matrilin, coiled-coil domain superfamily
    IPR019466 Matrilin, coiled-coil trimerisation domain
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39612
References
more
  • Summaries
    All 51
    Developmental Gene Expression 12
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory