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Enc1 Gene Detail
Summary
  • Symbol
    Enc1
  • Name
    ectodermal-neural cortex 1
  • Synonyms
    Nrpb, PIG10
  • Feature Type
    protein coding gene
  • IDs
    MGI:109610
    NCBI Gene: 13803
  • Gene Overview
    MyGene.info: ENC1
Location & Maps
more
  • Sequence Map
    Chr13:97241105-97253039 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11935 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 50.66 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ENC1, ectodermal-neural cortex 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ENC1, ectodermal-neural cortex 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10
  • Links
    NCBI Gene ID: 8507
    neXtProt AC: NX_O14682

  • Chr Location
    5q13; chr5:74627406-74641424 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Gene trapped
    22
  • Targeted
    1
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041773 Ensembl Gene Model | MGI Sequence Detail 11935 C57BL/6J ±  kb
transcript ENSMUST00000041623 Ensembl | MGI Sequence Detail 4742 Not Applicable  
polypeptide ENSMUSP00000038783 Ensembl | MGI Sequence Detail 589 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    129 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 115
    Genomic 1
    cDNA 113
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-39609, MGI:1278341
References
more
  • Summaries
    All 45
    Developmental Gene Expression 13
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:39574 Hernandez MC, et al., ENC-1: a novel mammalian kelch-related gene specifically expressed in the nervous system encodes an actin-binding protein. J Neurosci. 1997 May 1;17(9):3038-51
  • Latest
    J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory