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Faah Gene Detail
Summary
  • Symbol
    Faah
  • Name
    fatty acid amide hydrolase
  • Feature Type
    protein coding gene
  • IDs
    MGI:109609
    NCBI Gene: 14073
Location & Maps
more
  • Sequence Map
    Chr4:115967145-116017926 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      50782 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.08 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FAAH, fatty acid amide hydrolase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FAAH, fatty acid amide hydrolase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAAH-1, PSAB
  • Links
    NCBI Gene ID: 2166
    neXtProt AC: NX_O00519

  • Chr Location
    1p35-p34; chr1:46394267-46413848 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with human FAAH associations

Human Disease Mouse Models
       Polysubstance Abuse, Susceptibility To; PSAB   OMIM: 606581
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Faah
  • Incidental Mutations
    Mutagenetix , APF
Homozygotes for a null allele show high brain anandamide (AEA) levels, reduced pain sensation, altered behavioral responses to AEA, and sex-specific changes in ethanol intake and sensitivity. Homozygotes for the C385A variant show enhanced cued fear extinction and reduced anxiety-like behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    165
  • Tissues
    24
  • cDNA Data
    71
  • Literature Summary
    5
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008726 VEGA Gene Model | MGI Sequence Detail 50782 C57BL/6J ±  kb
transcript OTTMUST00000019833 VEGA | MGI Sequence Detail 3827 Not Applicable  
polypeptide OTTMUSP00000009093 VEGA | MGI Sequence Detail 579 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    176 from dbSNP Build 142
  • PCR
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 74
    Genomic 1
    cDNA 71
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-39608, MGI:2140571
References
more
  • Summaries
    All 96
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 63
  • Earliest
    J:39332 Giang DK, et al., Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2238-42
  • Latest
    J:233336 Siegmund SV, et al., Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells. Biochem Biophys Res Commun. 2016 Feb 12;470(3):678-84
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory