Faah
Gene Detail

Symbol Name ID

Faah fatty acid amide hydrolase MGI:109609

Feature Type

protein coding gene

Genetic Map

Chromosome 4

53.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:115967145-116017926 bp, - strand From VEGA annotation of GRCm38   50782 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68184  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: amidase, fungal type
Gene Tree: Faah

Human homologs

Human Homolog		FAAH, fatty acid amide hydrolase
NCBI Gene ID		2166
neXtProt AC		NX_O00519
Human Synonyms		FAAH-1, PSAB
Human Chr (Location)		1p35-p34; chr1:46859939-46879520 (+)  GRCh37.p13
Disease Associations		(1) Diseases Associated with Human FAAH

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene show a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	fatty acid catabolic process, fatty acid metabolic process
Component	endoplasmic reticulum, Golgi apparatus, ...
Function	acylglycerol lipase activity, amidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (165)    Tissues (24)    Images (39)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	165

cDNA source data(71)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(74) Genomic(1) cDNA(71) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000008726 (Evidence)
Ensembl Gene Model	ENSMUSG00000034171 (Evidence)
Entrez Gene	14073 (Evidence)
UniGene	256025
DFCI	TC1574604, TC1590719, TC1608076, TC1740699
DoTS	DT.101123164, DT.101123172, DT.101159327, DT.50315535, DT.55207737, DT.91316230
EC	3.5.1.99
Consensus CDS Project	CCDS18501.1
International Mouse Knockout Project Status	Faah

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008726	VEGA Gene Model | MGI Sequence Detail	50782	C57BL/6J
transcript	OTTMUST00000019833	VEGA | MGI Sequence Detail	3827	Not Applicable
polypeptide	OTTMUSP00000009093	VEGA | MGI Sequence Detail	579	Not Applicable

All sequences(67) RefSeq(6) UniProt(4)

Polymorphisms

PCR(1) : SNPs within 2kb(180 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000120	Amidase
InterPro	IPR020556	Amidase, conserved site
InterPro	IPR015830	Amidase, fungi
InterPro	IPR023631	Amidase signature domain
Protein Ontology	PR:000007305	fatty-acid amide hydrolase 1

References

(Earliest) J:39332 Giang DK, et al., Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2238-42
(Latest) J:205325 Siegmund SV, et al., Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. Biochem Biophys Res Commun. 2013 Jul 19;437(1):48-54
All references(85)

Other accession IDs

MGD-MRK-39608, MGI:2140571