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Faah Gene Detail
Summary
  • Symbol
    Faah
  • Name
    fatty acid amide hydrolase
  • Feature Type
    protein coding gene
  • IDs
    MGI:109609
    NCBI Gene: 14073
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr4:115967145-116017926 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      50782 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.08 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FAAH, fatty acid amide hydrolase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FAAH, fatty acid amide hydrolase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FAAH-1, PSAB
  • Links
    NCBI Gene ID: 2166
    neXtProt AC: NX_O00519
    UniProt: O00519

  • Chr Location
    1p33; chr1:46394267-46413848 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show high brain anandamide (AEA) levels, reduced pain sensation, altered behavioral responses to AEA, and sex-specific changes in ethanol intake and sensitivity. Homozygotes for the C385A variant show enhanced cued fear extinction and reduced anxiety-like behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    172
  • Tissues
    29
  • cDNA Data
    72
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000008726 VEGA Gene Model | MGI Sequence Detail 50782 C57BL/6J ±  kb
    transcript OTTMUST00000019833 VEGA | MGI Sequence Detail 3827 Not Applicable  
    polypeptide OTTMUSP00000009093 VEGA | MGI Sequence Detail 579 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      176 from dbSNP Build 142
    • PCR
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 1
      cDNA 72
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39608, MGI:2140571
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 69
    • Earliest
      J:39332 Giang DK, et al., Molecular characterization of human and mouse fatty acid amide hydrolases. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2238-42
    • Latest
      J:258275 Sun X, et al., Metformin attenuates susceptibility to inflammation-induced preterm birth in mice with higher endocannabinoid levels. Biol Reprod. 2018 Feb 1;98(2):208-217
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/18/2018
    MGI 6.12     		The Jackson Laboratory