About   Help   FAQ
Fap Gene Detail
Summary
  • Symbol
    Fap
  • Name
    fibroblast activation protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:109608
    NCBI Gene: 14089
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:62500943-62574075 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 35.85 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    364 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109608
protein coding gene Chr2:62500936-62575510 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025771
protein coding gene Chr2:62190075-62269099 (-)
A/J MGP_AJ_G0025747
protein coding gene Chr2:59807334-59882366 (-)
AKR/J MGP_AKRJ_G0025717
protein coding gene Chr2:61406163-61481355 (-)
BALB/cJ MGP_BALBcJ_G0025742
protein coding gene Chr2:59916049-59997474 (-)
C3H/HeJ MGP_C3HHeJ_G0025503
protein coding gene Chr2:61518258-61595149 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026189
protein coding gene Chr2:64010754-64088502 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023593
protein coding gene Chr2:57326022-57400271 (-)
CAST/EiJ MGP_CASTEiJ_G0024967
protein coding gene Chr2:61589424-61666483 (-)
CBA/J MGP_CBAJ_G0025483
protein coding gene Chr2:66437457-66528805 (-)
DBA/2J MGP_DBA2J_G0025614
protein coding gene Chr2:59388725-59462566 (-)
FVB/NJ MGP_FVBNJ_G0025576
protein coding gene Chr2:58910745-58984974 (-)
LP/J MGP_LPJ_G0025702
protein coding gene Chr2:62020805-62094776 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025607
protein coding gene Chr2:68141764-68221688 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026246
protein coding gene Chr2:61480000-61556617 (-)
PWK/PhJ MGP_PWKPhJ_G0024708
protein coding gene Chr2:59254772-59328468 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024515
protein coding gene Chr2:61628138-61703798 (-)
WSB/EiJ MGP_WSBEiJ_G0025035
protein coding gene Chr2:61802927-61882196 (-)



Homology
more
  • Human Ortholog
    FAP, fibroblast activation protein alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FAP, fibroblast activation protein alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DPPIV, FAPA, FAPalpha, SIMP
  • Links
    NCBI Gene ID: 2191
    neXtProt AC: NX_Q12884
    UniProt: Q12884

  • Chr Location
    2q24.2; chr2:162170684-162243535 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Mice homozygous for a targeted null mutations exhibit no discernable phenotype; mice are viable and fertile with no change in cancer susceptibility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000392 Ensembl Gene Model | MGI Sequence Detail 73133 C57BL/6J ±  kb
transcript ENSMUST00000102732 Ensembl | MGI Sequence Detail 2751 Not Applicable  
polypeptide ENSMUSP00000099793 Ensembl | MGI Sequence Detail 761 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 1
    cDNA 15
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39607
References
more
  • Summaries
    All 41
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:40036 Niedermeyer J, et al., Mouse fibroblast activation protein: Molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers. Int J Cancer. 1997 MAY 2;71(3):383-389
  • Latest
    J:255682 Bainbridge TW, et al., Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP). Sci Rep. 2017 Oct 2;7(1):12524

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory