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Fap Gene Detail
Summary
  • Symbol
    Fap
  • Name
    fibroblast activation protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:109608
    NCBI Gene: 14089
Location & Maps
more
  • Sequence Map
    Chr2:62500943-62574075 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      73133 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FAP, fibroblast activation protein alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FAP, fibroblast activation protein alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DPPIV, FAPA, SIMP
  • Links
    NCBI Gene ID: 2191
    neXtProt AC: NX_Q12884

  • Chr Location
    2q23; chr2:162170684-162243535 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    9 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Fap
  • Incidental Mutations
Mice homozygous for a targeted null mutations exhibit no discernable phenotype; mice are viable and fertile with no change in cancer susceptibility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012825 VEGA Gene Model | MGI Sequence Detail 73133 C57BL/6J ±  kb
transcript OTTMUST00000030765 VEGA | MGI Sequence Detail 2751 Not Applicable  
polypeptide OTTMUSP00000013791 VEGA | MGI Sequence Detail 761 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    364 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
less
  • All nucleic 19
    Genomic 1
    cDNA 14
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-39607
References
more
  • Summaries
    All 31
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:40036 Niedermeyer J, et al., Mouse fibroblast activation protein: Molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers. Int J Cancer. 1997 MAY 2;71(3):383-389
  • Latest
    J:208419 Basta JM, et al., Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory