About   Help   FAQ
Fap
Gene Detail
Symbol

Name
ID
Fap
fibroblast activation protein
MGI:109608
Feature Type
protein coding gene
Genetic Map
Chromosome 2
35.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:62500943-62574075 bp, - strand
From VEGA annotation of GRCm38

  73133 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48282  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: FAP
Protein SuperFamily: dipeptidyl-peptidase IV
Gene Tree: Fap

Human
homologs
FAP, fibroblast activation protein, alpha
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2191
neXtProt AC: NX_Q12884

Human Synonyms: DPPIV, FAPA, SIMP

Human Chr (Location): 2q23; chr2:162170684-162243535 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null mutations exhibit no discernable phenotype; mice are viable and fertile with no change in cancer susceptibility.
 
Interactions
Fap interacts with 103 markers (Mir7-1, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process angiogenesis, apoptotic process, ...
Component apical part of cell, basal part of cell, ...
Function dipeptidyl-peptidase activity, endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (263)    Tissues (80)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 221
RT-PCR 42
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fap    NEW 
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(14) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000012825 (Evidence)
Ensembl Gene Model ENSMUSG00000000392 (Evidence)
Entrez Gene 14089 (Evidence)
UniGene 41816
DFCI TC1582653
DoTS DT.60103337, DT.97358068
NIA Mouse Gene Index U022676
EC 3.4.21.-, 3.4.14.5, 3.4.21.26
Consensus CDS Project CCDS16067.1
International Mouse Phenotyping Consortium Status Fap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012825 VEGA Gene Model | MGI Sequence Detail 73133 C57BL/6J ±  kb
transcript OTTMUST00000030765 VEGA | MGI Sequence Detail 2751 Not Applicable 
polypeptide OTTMUSP00000013791 VEGA | MGI Sequence Detail 761 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(361 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002469 Peptidase S9B, dipeptidylpeptidase IV N-terminal
InterPro IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
InterPro IPR002471 Peptidase S9, serine active site
Protein Ontology PR:000007340 seprase
References
(Earliest) J:40036 Niedermeyer J, et al., Mouse fibroblast activation protein: Molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers. Int J Cancer. 1997 MAY 2;71(3):383-389
(Latest) J:208419 Basta JM, et al., Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58
All references(35)
Other
accession IDs
MGD-MRK-39607

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory