Fnbp1 MGI Mouse Gene Detail - MGI:109606 - formin binding protein 1

Symbol

Fnbp1
Name

formin binding protein 1
Synonyms

1110057E06Rik, 2210010H06Rik, FBP1, FBP17

Feature Type

protein coding gene
IDs

MGI:109606
NCBI Gene: 14269
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr2:30916218-31032020 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.78 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

5822 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109606	protein coding gene	Chr2:30916218-31032046 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025581	protein coding gene	Chr2:29326727-29452196 (-)
A/J	MGP_AJ_G0025559	protein coding gene	Chr2:28135583-28253905 (-)
AKR/J	MGP_AKRJ_G0025528	protein coding gene	Chr2:29092541-29215984 (-)
BALB/cJ	MGP_BALBcJ_G0025555	protein coding gene	Chr2:28270469-28388241 (-)
C3H/HeJ	MGP_C3HHeJ_G0025316	protein coding gene	Chr2:29025414-29147981 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026000	protein coding gene	Chr2:30274572-30404499 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023408	protein coding gene	Chr2:26899806-27018500 (-)
CAST/EiJ	MGP_CASTEiJ_G0024778	protein coding gene	Chr2:28959883-29081410 (-)
CBA/J	MGP_CBAJ_G0025293	protein coding gene	Chr2:31348730-31493071 (-)
DBA/2J	MGP_DBA2J_G0025426	protein coding gene	Chr2:27911324-28029632 (-)
FVB/NJ	MGP_FVBNJ_G0025389	protein coding gene	Chr2:27753650-27872674 (-)
LP/J	MGP_LPJ_G0025512	protein coding gene	Chr2:29235043-29361666 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025419	protein coding gene	Chr2:31134797-31262876 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026058	protein coding gene	Chr2:29008722-29133950 (-)
PWK/PhJ	MGP_PWKPhJ_G0024525	protein coding gene	Chr2:27786474-27915411 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024325	protein coding gene	Chr2:29151820-29276375 (-)
WSB/EiJ	MGP_WSBEiJ_G0024846	protein coding gene	Chr2:29184496-29310442 (-)

Human Ortholog

FNBP1, formin binding protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FNBP1, formin binding protein 1
Synonyms

FBP17
Links

HGNC:17069

NCBI Gene ID: 23048

UniProt: Q96RU3
Chr Location

9q34.11; chr9:129887187-130053879 (-) GRCh38

MGI Vertebrate Homology

Fnbp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FNBP1
Gene Tree

Fnbp1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

325
Endonuclease-mediated

4
Gene trapped

321
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

334 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

14
cDNA Data

20
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FNBP1

Xenbase fnbp1

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All Sequences

133
RefSeq

49
UniProt

12
CCDS

CCDS15894.1, CCDS38097.1, CCDS50560.1, CCDS50561.1, CCDS57165.1

Ensembl

ENSMUSG00000075415 (Evidence)
NCBI Gene

14269

			Length	Strain/Species	Flank
genomic	ENSMUSG00000075415	Ensembl Gene Model \| MGI Sequence Detail	115803	C57BL/6J	± kb
transcript	ENSMUST00000113560	Ensembl \| MGI Sequence Detail	4726	Not Applicable
polypeptide	ENSMUSP00000109190	Ensembl \| MGI Sequence Detail	616	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000007584 formin-binding protein 1

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR031160 F-BAR domain

IPR001060 FCH domain

IPR035492 FNBP1, SH3 domain

IPR037449 Formin-binding protein 1, F-BAR domain

IPR011072 HR1 rho-binding domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 21

cDNA 20

Primer pair 1

Microarray probesets 9

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MGD-MRK-39605, MGI:1916093, MGI:1917318

Summaries

All 42

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 12
Earliest

J:38792 Chan DC, et al., Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 1996 Mar 1;15(5):1045-54
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fnbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23432	Chr2:31032031-31032040 (-)	-16 bp
Tssr23431	Chr2:31032014-31032029 (-)	-2 bp
Tssr23430	Chr2:31031955-31032013 (-)	36 bp
Tssr23429	Chr2:31006301-31006332 (-)	25,703 bp
Tssr23428	Chr2:30990997-30991007 (-)	41,018 bp
Tssr23427	Chr2:30944209-30944221 (-)	87,805 bp
Tssr23426	Chr2:30943608-30943620 (-)	88,406 bp
Tssr23425	Chr2:30941193-30941210 (-)	90,818 bp
Tssr23424	Chr2:30926795-30926806 (-)	105,219 bp
Tssr23423	Chr2:30926762-30926777 (-)	105,250 bp
Tssr23422	Chr2:30925736-30925784 (-)	106,260 bp
Tssr23421	Chr2:30925528-30925563 (-)	106,474 bp
Tssr23420	Chr2:30921870-30921874 (-)	110,148 bp
Tssr23419	Chr2:30921779-30921791 (-)	110,235 bp
Tssr23418	Chr2:30921668-30921672 (-)	110,350 bp
Tssr23417	Chr2:30920800-30920815 (-)	111,212 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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