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Cmklr1 Gene Detail
Summary
  • Symbol
    Cmklr1
  • Name
    chemerin chemokine-like receptor 1
  • Synonyms
    ChemR23, Gpcr27
  • Feature Type
    protein coding gene
  • IDs
    MGI:109603
    NCBI Gene: 14747
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:113750415-113788487 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.55 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109603
protein coding gene Chr5:113750415-113792971 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029919
protein coding gene Chr5:116281724-116321945 (-)
A/J MGP_AJ_G0029884
protein coding gene Chr5:111727556-111765573 (-)
AKR/J MGP_AKRJ_G0029822
protein coding gene Chr5:115267633-115307369 (-)
BALB/cJ MGP_BALBcJ_G0029895
protein coding gene Chr5:113092856-113130885 (-)
C3H/HeJ MGP_C3HHeJ_G0029615
protein coding gene Chr5:115741628-115780776 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030349
protein coding gene Chr5:120803936-120842806 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027577
protein coding gene Chr5:106553796-106592880 (-)
CAST/EiJ MGP_CASTEiJ_G0029023
protein coding gene Chr5:114678462-114716305 (-)
CBA/J MGP_CBAJ_G0029582
protein coding gene Chr5:125367103-125404874 (-)
DBA/2J MGP_DBA2J_G0029732
protein coding gene Chr5:111794597-111832575 (-)
FVB/NJ MGP_FVBNJ_G0029689
protein coding gene Chr5:110561917-110602482 (-)
LP/J MGP_LPJ_G0029821
protein coding gene Chr5:116846042-116885487 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029720
protein coding gene Chr5:129861267-129900322 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030390
protein coding gene Chr5:114723144-114761167 (-)
PWK/PhJ MGP_PWKPhJ_G0028737
protein coding gene Chr5:110419099-110457941 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028575
protein coding gene Chr5:112247920-112286772 (-)
WSB/EiJ MGP_WSBEiJ_G0029099
protein coding gene Chr5:115273145-115315039 (-)



Homology
more
  • Human Ortholog
    CMKLR1, chemerin chemokine-like receptor 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CMKLR1, chemerin chemokine-like receptor 1
  • Synonyms
    CHEMERINR, ChemR23, DEZ, ERV1, RVER1
  • Links
    NCBI Gene ID: 1240
    neXtProt AC: NX_Q99788
    UniProt: Q99788

  • Chr Location
    12q23.3; chr12:108288044-108339317 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have defects in immunomodulation of monocyte and neutriphils by chemerin
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042190 Ensembl Gene Model | MGI Sequence Detail 38073 C57BL/6J ±  kb
    transcript ENSMUST00000047936 Ensembl | MGI Sequence Detail 2882 Not Applicable  
    polypeptide ENSMUSP00000036316 Ensembl | MGI Sequence Detail 371 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39602
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 39
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:340632 Hernandez J, et al., n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout. Int J Mol Sci. 2023 Aug 31;24(17)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory