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Cmklr1
Gene Detail
 Symbol
Name
ID
Cmklr1
chemokine-like receptor 1
MGI:109603
Synonyms ChemR23, Gpcr27
Feature Type protein coding gene
Genetic Map
Chromosome 5
55.55 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:113612354-113650426 bp, - strand
From VEGA annotation of GRCm38

  38073 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129967  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: chemokine receptor-like protein CMKLR1
Gene Tree: Cmklr1

Human
homologs
Human Homolog CMKLR1, chemokine-like receptor 1
NCBI Gene ID 1240
neXtProt AC  NX_Q99788
Human Synonyms  CHEMERINR, ChemR23, DEZ, RVER1
Human Chr (Location)  12q24.1; chr12:108288044-108339317 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(16) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have defects in immunomodulation of monocyte and neutriphils by chemerin
 
Interactions
Cmklr1 interacts with 145 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chemotaxis, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function chemokine receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (93)    Tissues (77)    Images (13)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 17
RNA in situ 75
Northern blot 1
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025812 (Evidence)
Ensembl Gene ModelENSMUSG00000042190 (Evidence)
Entrez Gene14747 (Evidence)
UniGene5196
DFCITC1585869
DoTSDT.110670456, DT.87035183
NIA Mouse Gene IndexU087647
Consensus CDS ProjectCCDS19551.1
International Mouse Knockout Project StatusCmklr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025812 VEGA Gene Model | MGI Sequence Detail 38073 C57BL/6J ±  kb
transcript OTTMUST00000063592 VEGA | MGI Sequence Detail 2882 Not Applicable 
polypeptide OTTMUSP00000031451 VEGA | MGI Sequence Detail 371 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(266 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR002258 DEZ orphan receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001129 chemokine receptor-like protein CMKLR1
References (Earliest) J:39842 Methner A, et al., A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development. Biochem Biophys Res Commun. 1997 Apr 17;233(2):336-42
(Latest) J:209826 Gonzalvo-Feo S, et al., Endothelial cell-derived chemerin promotes dendritic cell transmigration. J Immunol. 2014 Mar 1;192(5):2366-73
All references(49)
Other
accession IDs
MGD-MRK-39602

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory