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Cmklr1
Gene Detail
Symbol

Name
ID
Cmklr1
chemokine-like receptor 1
MGI:109603
Synonyms
ChemR23, Gpcr27
Feature Type
protein coding gene
Genetic Map
Chromosome 5
55.55 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:113612354-113650426 bp, - strand
From VEGA annotation of GRCm38

  38073 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129967  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CMKLR1
Protein SuperFamily: chemokine receptor-like protein CMKLR1
Gene Tree: Cmklr1

Human
homologs
CMKLR1, chemerin chemokine-like receptor 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1240
neXtProt AC: NX_Q99788

Human Synonyms: CHEMERINR, ChemR23, DEZ, RVER1

Human Chr (Location): 12q24.1; chr12:108288044-108339317 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(16) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have defects in immunomodulation of monocyte and neutriphils by chemerin
 
Interactions
Cmklr1 interacts with 144 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chemotaxis, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function chemokine receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (93)    Tissues (77)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 75
Northern blot 1
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cmklr1    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000025812 (Evidence)
Ensembl Gene Model ENSMUSG00000042190 (Evidence)
Entrez Gene 14747 (Evidence)
UniGene 5196
DFCI TC1585869
DoTS DT.87035183, DT.110670456
NIA Mouse Gene Index U087647
Consensus CDS Project CCDS19551.1
International Mouse Phenotyping Consortium Status Cmklr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025812 VEGA Gene Model | MGI Sequence Detail 38073 C57BL/6J ±  kb
transcript OTTMUST00000063592 VEGA | MGI Sequence Detail 2882 Not Applicable 
polypeptide OTTMUSP00000031451 VEGA | MGI Sequence Detail 371 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(266 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR002258 DEZ orphan receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001129 chemokine receptor-like protein CMKLR1
References
(Earliest) J:39842 Methner A, et al., A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development. Biochem Biophys Res Commun. 1997 Apr 17;233(2):336-42
(Latest) J:215271 Gruben N, et al., Chemokine-like receptor 1 deficiency does not affect the development of insulin resistance and nonalcoholic fatty liver disease in mice. PLoS One. 2014;9(4):e96345
All references(49)
Other
accession IDs
MGD-MRK-39602

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory