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Nck1
Gene Detail
 Symbol
Name
ID
Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
MGI:109601
Synonyms 6330586M15Rik, D230010O13Rik, Nck
Feature Type protein coding gene
Genetic Map
Chromosome 9
52.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:100492293-100546053 bp, - strand
From VEGA annotation of GRCm38

  53761 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38148  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: adapter protein NCK
Gene Tree: Nck1

Human
homologs
Human Homolog NCK1, NCK adaptor protein 1
NCBI Gene ID 4690
neXtProt AC  NX_P16333
Human Synonyms  NCK, nck-1, NCKalpha
Human Chr (Location)  3q21; chr3:136862208-136951604 (+)  GRCh38
Alleles
and
phenotypes
All alleles(31) : Gene trapped(26) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene display no abnormal phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process actin filament organization, cell migration, ...
Component cell-cell junction, cytoplasm, ...
Function kinase activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (57)    Tissues (31)    Images (1)
Theiler Stages: 11, 13, 17, 28
Assay TypeResults
In situ reporter (knock in) 33
Northern blot 8
Western blot 16
cDNA source data(50)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(53) cDNA(53)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021049 (Evidence)
Ensembl Gene ModelENSMUSG00000032475 (Evidence)
Entrez Gene17973 (Evidence)
UniGene181485
DFCITC1578812, TC1587583, TC1714160
DoTSDT.101710220, DT.529820
NIA Mouse Gene IndexU031242
Consensus CDS ProjectCCDS23440.1
International Mouse Knockout Project StatusNck1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021049 VEGA Gene Model | MGI Sequence Detail 53761 C57BL/6J ±  kb
transcript OTTMUST00000049788 VEGA | MGI Sequence Detail 4395 Not Applicable 
polypeptide OTTMUSP00000023124 VEGA | MGI Sequence Detail 377 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(416 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017304 Cytoplasmic, NCK
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000011033 cytoplasmic protein NCK1
References (Earliest) J:39581 Margolis B, et al., High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8894-8
(Latest) J:208233 Castello A, et al., Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells. Nat Immunol. 2013 Sep;14(9):966-75
All references(68)
Other
accession IDs
MGD-MRK-39600, MGI:1097154, MGI:2441714, MGI:2441955

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory