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Nck1 Gene Detail
Summary
  • Symbol
    Nck1
  • Name
    non-catalytic region of tyrosine kinase adaptor protein 1
  • Synonyms
    6330586M15Rik, D230010O13Rik, Nck
  • Feature Type
    protein coding gene
  • IDs
    MGI:109601
    NCBI Gene: 17973
  • Gene Overview
    MyGene.info: NCK1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:100494302-100546134 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 52.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    391 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109601
protein coding gene Chr9:100492293-100546134 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035177
protein coding gene Chr9:101933343-101988637 (-)
A/J MGP_AJ_G0035158
protein coding gene Chr9:98333225-98388106 (-)
AKR/J MGP_AKRJ_G0035090
protein coding gene Chr9:100735937-100787941 (-)
BALB/cJ MGP_BALBcJ_G0035151
protein coding gene Chr9:98014688-98066653 (-)
C3H/HeJ MGP_C3HHeJ_G0034861
protein coding gene Chr9:101155388-101210260 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035671
protein coding gene Chr9:104850080-104906274 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032570
protein coding gene Chr9:95979653-96031132 (-)
CAST/EiJ MGP_CASTEiJ_G0034172
protein coding gene Chr9:100939097-100997786 (-)
CBA/J MGP_CBAJ_G0034829
protein coding gene Chr9:108475276-108542564 (-)
DBA/2J MGP_DBA2J_G0034991
protein coding gene Chr9:97816060-97868978 (-)
FVB/NJ MGP_FVBNJ_G0034939
protein coding gene Chr9:96629255-96680515 (-)
LP/J MGP_LPJ_G0035067
protein coding gene Chr9:102161265-102214682 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034978
protein coding gene Chr9:110352434-110412696 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035693
protein coding gene Chr9:100985457-101041756 (-)
PWK/PhJ MGP_PWKPhJ_G0033879
protein coding gene Chr9:98045582-98094053 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033715
protein coding gene Chr9:101038425-101098350 (-)
WSB/EiJ MGP_WSBEiJ_G0034292
protein coding gene Chr9:100849244-100903064 (-)



Homology
more
  • Human Ortholog
    NCK1, NCK adaptor protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NCK1, NCK adaptor protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NCK, nck-1, NCKalpha
  • Links
    NCBI Gene ID: 4690
    neXtProt AC: NX_P16333
    UniProt: P16333

  • Chr Location
    3q22.3; chr3:136862208-136951610 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    29 phenotypes from multigenic genotypes
    30 phenotype references
Mice homozygous for disruption of this gene display no abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17973 NCBI Gene Model | MGI Sequence Detail 51833 C57BL/6J ±  kb
transcript NM_010878 RefSeq | MGI Sequence Detail 2467 C57BL/6  
polypeptide Q99M51 UniProt | EBI | MGI Sequence Detail 377 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    cDNA 54

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-39600, MGI:1097154, MGI:2441714, MGI:2441955
References
more
  • Summaries
    All 85
    Developmental Gene Expression 7
    Gene Ontology 19
    Phenotypes 30
  • Earliest
    J:39581 Margolis B, et al., High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8894-8
  • Latest
    J:239043 Dubrac A, et al., Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization. Circulation. 2016 Jan 26;133(4):409-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory