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Has3
Gene Detail
Symbol

Name
ID
Has3
hyaluronan synthase 3
MGI:109599
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:106870242-106884566 bp, + strand
From VEGA annotation of GRCm38

  14325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HAS3
Gene Tree: Has3

Human
homologs
HAS3, hyaluronan synthase 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3038
neXtProt AC: NX_O00219

Human Chr (Location): 16q22.1; chr16:69105564-69118719 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele are viable and fertile with normal static and dynamic compliances and display a reduced high tidal volume ventilation-induced inflammatory response.
 
Interactions
Has3 interacts with 371 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell adhesion, extracellular matrix assembly, ...
Component hyaluranon cable, integral component of membrane, ...
Function hyaluronan synthase activity, transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (200)    Tissues (119)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 196
Northern blot 4
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN has3    NEW 
Molecular
reagents
All nucleic(14) Genomic(3) cDNA(10) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000042123 (Evidence)
Ensembl Gene Model ENSMUSG00000031910 (Evidence)
Entrez Gene 15118 (Evidence)
UniGene 56986
DFCI TC1589738, TC1717429
DoTS DT.101722284, DT.55161144
NIA Mouse Gene Index U009780
EC 2.4.1.212
Consensus CDS Project CCDS22640.1
International Mouse Phenotyping Consortium Status Has3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042123 VEGA Gene Model | MGI Sequence Detail 14325 C57BL/6J ±  kb
transcript OTTMUST00000110503 VEGA | MGI Sequence Detail 5912 Not Applicable 
polypeptide OTTMUSP00000061646 VEGA | MGI Sequence Detail 554 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026108 Hyaluronan synthase 3
InterPro IPR026107 Hyaluronan synthase/nodulation protein C
InterPro IPR029044 Nucleotide-diphospho-sugar transferases
Protein Ontology PR:000008451 hyaluronan synthase 3
References
(Earliest) J:39422 Hoock TC, et al., Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. J Cell Biol. 1997 Mar 10;136(5):1059-70
(Latest) J:219524 Akgul Y, et al., Hyaluronan in cervical epithelia protects against infection-mediated preterm birth. J Clin Invest. 2014 Dec;124(12):5481-9
All references(47)
Other
accession IDs
MGD-MRK-39598

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory