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Has3
Gene Detail
 Symbol
Name
ID
Has3
hyaluronan synthase 3
MGI:109599
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:106870242-106884566 bp, + strand
From VEGA annotation of GRCm38

  14325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Has3

Human
homologs
Human Homolog HAS3, hyaluronan synthase 3
NCBI Gene ID 3038
neXtProt AC  NX_O00219
Human Chr (Location)  16q22.1; chr16:69105564-69118719 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele are viable and fertile with normal static and dynamic compliances and display a reduced high tidal volume ventilation-induced inflammatory response.
 
Interactions
Has3 interacts with 371 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process extracellular matrix assembly, extracellular polysaccharide biosynthetic process, ...
Component hyaluranon cable, integral component of membrane, ...
Function hyaluronan synthase activity, transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (200)    Tissues (119)    Images (24)
Theiler Stages: 11, 19, 22, 23, 25
Assay TypeResults
RNA in situ 196
Northern blot 4
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(3) cDNA(10) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042123 (Evidence)
Ensembl Gene ModelENSMUSG00000031910 (Evidence)
Entrez Gene15118 (Evidence)
UniGene56986
DFCITC1589738, TC1717429
DoTSDT.101722284, DT.55161144
NIA Mouse Gene IndexU009780
EC2.4.1.212
Consensus CDS ProjectCCDS22640.1
International Mouse Knockout Project StatusHas3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042123 VEGA Gene Model | MGI Sequence Detail 14325 C57BL/6J ±  kb
transcript OTTMUST00000110503 VEGA | MGI Sequence Detail 5912 Not Applicable 
polypeptide OTTMUSP00000061646 VEGA | MGI Sequence Detail 554 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026108 Hyaluronan synthase 3
InterPro IPR026107 Hyaluronan synthase/nodulation protein C
Protein Ontology PR:000008451 hyaluronan synthase 3
References (Earliest) J:39422 Hoock TC, et al., Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. J Cell Biol. 1997 Mar 10;136(5):1059-70
(Latest) J:210601 Arranz AM, et al., Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space. J Neurosci. 2014 Apr 30;34(18):6164-76
All references(44)
Other
accession IDs
MGD-MRK-39598

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory