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Hsd3b6 Gene Detail
Summary
  • Symbol
    Hsd3b6
  • Name
    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
  • Synonyms
    3beta-HSD VI
  • Feature Type
    protein coding gene
  • IDs
    MGI:109598
    NCBI Gene: 15497
  • Member of
    Hsd3b cluster
Location & Maps
more
  • Sequence Map
    Chr3:98805504-98814443 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8940 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 42.88 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HSD3B1, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    HSD3B1, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1
  • Links
    NCBI Gene ID: 3283
    neXtProt AC: NX_P14060

  • Chr Location
    1p13.1; chr1:119507124-119515060 (+)  GRCh38.p2

  • Human Ortholog
    HSD3B2, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
    Orthology source: HGNC
  • Synonyms
    HSD3B, HSDB, SDR11E2
  • Links
    NCBI Gene ID: 3284
    neXtProt AC: NX_P26439

  • Chr Location
    1p13.1; chr1:119414931-119423039 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HSD3B2 associations

Human Disease Mouse Models
       Adrenal Hyperplasia, Congenital, Due to 3-Beta-Hydroxysteroid Dehydrogenase 2 Deficiency   OMIM: 201810
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Hsd3b6
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006781 VEGA Gene Model | MGI Sequence Detail 8940 C57BL/6J ±  kb
transcript OTTMUST00000015592 VEGA | MGI Sequence Detail 1802 Not Applicable  
polypeptide OTTMUSP00000007181 VEGA | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    86 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    Genomic 1
    cDNA 24
    Primer pair 6

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39597, MGI:2140104
References
more
  • Summaries
    All 36
    Developmental Gene Expression 13
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:39896 Abbaszade IG, et al., Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase isoform, 3beta-HSD VI, expressed during early pregnancy. Endocrinology. 1997 Apr;138(4):1392-9
  • Latest
    J:227422 Karpova T, et al., Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice. Biol Reprod. 2015 Oct;93(4):83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory