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Hsd3b6
Gene Detail
 Symbol
Name
ID
Member of
Hsd3b6
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
MGI:109598
Hsd3b cluster
Synonyms 3beta-HSD VI
Feature Type protein coding gene
Genetic Map
Chromosome 3
42.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:98805504-98814443 bp, - strand
From VEGA annotation of GRCm38

  8940 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133013  Vertebrate Homology Class
1 human; 3 mouse; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: bifunctional 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
Gene Tree: Hsd3b6

Human
homologs
Human Homolog HSD3B1, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
NCBI Gene ID 3283
neXtProt AC  NX_P14060
Human Synonyms  3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1
Human Chr (Location)  1p13.1; chr1:119507203-119515058 (+)  GRCh38
Mutations,
alleles, and
phenotypes
Incidental mutations (data from APF )
Interactions
Hsd3b6 interacts with 99 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process metabolic process, oxidation-reduction process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function 2-hydroxytetrahydrofuran dehydrogenase activity, 3-beta-hydroxy-delta5-steroid dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (145)    Tissues (115)    Images (17)
Theiler Stages: 10, 13, 15, 17, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 100
Western blot 2
RT-PCR 43
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(24) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006781 (Evidence)
Ensembl Gene ModelENSMUSG00000027869 (Evidence)
Entrez Gene15497 (Evidence)
UniGene14435
DFCITC1582539
DoTSDT.94403118, DT.94403119
NIA Mouse Gene IndexU024419
EC1.1.1.-, 1.1.1.145, 5.3.3.1
Consensus CDS ProjectCCDS17669.1
International Mouse Knockout Project StatusHsd3b6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006781 VEGA Gene Model | MGI Sequence Detail 8940 C57BL/6J ±  kb
transcript OTTMUST00000015592 VEGA | MGI Sequence Detail 1802 Not Applicable 
polypeptide OTTMUSP00000007181 VEGA | MGI Sequence Detail 373 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(3) UniProt(4)
Polymorphisms SNPs within 2kb(92 from dbSNP Build 137)    SNPs within 2kb including multiple locations(100)
Protein-related
information
ResourceIDDescription
InterPro IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000008870 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6
References (Earliest) J:33962 Clarke TR, et al., Isolation and characterization of several members of the murine Hsd3b gene family. DNA Cell Biol. 1996 May;15(5):387-99
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(33)
Other
accession IDs
MGD-MRK-39597, MGI:2140104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory