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Prpf4b Gene Detail
Summary
  • Symbol
    Prpf4b
  • Name
    pre-mRNA processing factor 4B
  • Synonyms
    MGC:5960, Prp4, Prp4k, Prpk
  • Feature Type
    protein coding gene
  • IDs
    MGI:109584
    NCBI Gene: 19134
  • Gene Overview
    MyGene.info: PRPF4B
Location & Maps
more
  • Sequence Map
    Chr13:34875494-34902877 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27384 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 14.21 cM, cytoband A5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PRPF4B, pre-mRNA processing factor 4B
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PRPF4B, pre-mRNA processing factor 4B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ1013A10.1, PR4H, PRP4, PRP4H, PRP4K
  • Links
    NCBI Gene ID: 8899
    neXtProt AC: NX_Q13523

  • Chr Location
    6p25.2; chr6:4021329-4064983 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotype references
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    9
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Prpf4b
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021413 Ensembl Gene Model | MGI Sequence Detail 27384 C57BL/6J ±  kb
transcript ENSMUST00000077853 Ensembl | MGI Sequence Detail 4465 Not Applicable  
polypeptide ENSMUSP00000077019 Ensembl | MGI Sequence Detail 1007 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    144 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013286 serine/threonine-protein kinase PRP4
  • EC
  • InterPro Domains
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-39583
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:38898 Gross T, et al., Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. Nucleic Acids Res. 1997 Mar 1;25(5):1028-35
  • Latest
    J:216294 Kumar A, et al., Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Int J Dev Neurosci. 2014 Nov;38:138-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory