Serpinb5
Gene Detail

Symbol Name ID

Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 MGI:109579

Synonyms

1110036M19Rik, Maspin, ovalbumin, Spi7

Feature Type

protein coding gene

Genetic Map

Chromosome 1

50.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:106861173-106883348 bp, + strand From VEGA annotation of GRCm38   22176 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20580  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: serpin
Gene Tree: Serpinb5

Human homologs

Human Homolog		SERPINB5, serpin peptidase inhibitor, clade B (ovalbumin), member 5
NCBI Gene ID		5268
neXtProt AC		NX_P36952
Human Synonyms		maspin, PI5
Human Chr (Location)		18q21.33; chr18:61144144-61172318 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous inactivation of this locus results in peri-implantation lethality. Homozygous null embryos exhibit impaired endoderm development and attenuated inner cell mass growth.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	extracellular matrix organization, morphogenesis of an epithelium, ...
Component	cytoplasm, extracellular region
Function	serine-type endopeptidase inhibitor activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (265)    Tissues (69)    Images (24)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	219
RT-PCR	46

cDNA source data(57)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(63) Genomic(5) cDNA(57) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000020990 (Evidence)
Ensembl Gene Model	ENSMUSG00000067006 (Evidence)
Entrez Gene	20724 (Evidence)
UniGene	268618
DFCI	TC1579213
DoTS	DT.101213064, DT.60118013, DT.97334073
NIA Mouse Gene Index	U000686
Consensus CDS Project	CCDS35684.1
International Mouse Knockout Project Status	Serpinb5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020990	VEGA Gene Model | MGI Sequence Detail	22176	C57BL/6J
transcript	OTTMUST00000049631	VEGA | MGI Sequence Detail	2672	Not Applicable
polypeptide	OTTMUSP00000023028	VEGA | MGI Sequence Detail	375	Not Applicable

All sequences(30) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(75 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR000240	Serpin B9/maspin
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000014696	serpin B5

References

(Earliest) J:39071 Zhang M, et al., mMaspin: the mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility. Mol Med. 1997 Jan;3(1):49-59
(Latest) J:188148 Landin MA, et al., Gene Expression Profiling during Murine Tooth Development. Front Genet. 2012;3:139
All references(41)

Other accession IDs

MGD-MRK-39578, MGI:1915965, MGI:2138262, MGI:2138309