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Serpinb5
Gene Detail
Symbol

Name
ID
Serpinb5
serine (or cysteine) peptidase inhibitor, clade B, member 5
MGI:109579
Synonyms
1110036M19Rik, Maspin, ovalbumin, Spi7
Feature Type
protein coding gene
Genetic Map
Chromosome 1
50.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:106861173-106883348 bp, + strand
From VEGA annotation of GRCm38

  22176 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20580  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: serpin
Gene Tree: Serpinb5

Human
homologs
Human Homolog SERPINB5, serpin peptidase inhibitor, clade B (ovalbumin), member 5
NCBI Gene ID 5268
neXtProt AC  NX_P36952
Human Synonyms  maspin, PI5
Human Chr (Location)  18q21.33; chr18:63476911-63505085 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
 
Mice homozygous for one null allele displayed peri-implantation lethality with impaired endoderm development and attenuated inner cell mass growth. Mice homozygous for another null allele were viable and fertile with no gross abnormalities.
 
Interactions
Serpinb5 interacts with 223 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process extracellular matrix organization, morphogenesis of an epithelium, ...
Component cytoplasm, extracellular region, ...
Function serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (283)    Tissues (83)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 237
RT-PCR 46
cDNA source data(57)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) Genomic(5) cDNA(57) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020990 (Evidence)
Ensembl Gene ModelENSMUSG00000067006 (Evidence)
Entrez Gene20724 (Evidence)
UniGene268618
DFCITC1579213
DoTSDT.60118013, DT.101213064, DT.97334073
NIA Mouse Gene IndexU000686
Consensus CDS ProjectCCDS35684.1
International Mouse Knockout Project StatusSerpinb5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020990 VEGA Gene Model | MGI Sequence Detail 22176 C57BL/6J ±  kb
transcript OTTMUST00000049631 VEGA | MGI Sequence Detail 2672 Not Applicable 
polypeptide OTTMUSP00000023028 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR000240 Serpin B9/maspin
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014696 serpin B5
References
(Earliest) J:39071 Zhang M, et al., mMaspin: the mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility. Mol Med. 1997 Jan;3(1):49-59
(Latest) J:206439 Teoh SS, et al., Maspin is not required for embryonic development or tumour suppression. Nat Commun. 2014;5:3164
All references(46)
Other
accession IDs
MGD-MRK-39578, MGI:1915965, MGI:2138262, MGI:2138309

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory