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Tecta Gene Detail
Summary
  • Symbol
    Tecta
  • Name
    tectorin alpha
  • Synonyms
    [a]-tectorin, Tctna
  • Feature Type
    protein coding gene
  • IDs
    MGI:109575
    NCBI Gene: 21683
Location & Maps
more
  • Sequence Map
    Chr9:42329619-42399929 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      70311 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TECTA, tectorin alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TECTA, tectorin alpha
    Orthology source: HomoloGene
  • Synonyms
    DFNA12, DFNA8, DFNB21
  • Links
    NCBI Gene ID: 7007
    neXtProt AC: NX_O75443

  • Chr Location
    11q22-q24; chr11:121102666-121190806 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tecta mouse models; 2 with human TECTA associations

Human Disease Mouse Models
       Deafness, Autosomal Dominant 12; DFNA12   OMIM: 601543 View 4 models
       Deafness, Autosomal Recessive 21; DFNB21   OMIM: 603629
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 6 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a tectorial membrane that is detached from the cochlear epithelium. Though the basilar membranes of mutant mice are tuned, sensitivity is attenuated. Mice with an Y1870C mutation have a disrupted tectorial membrane, elevated neural thresholds and broadened neural tuning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034859 VEGA Gene Model | MGI Sequence Detail 70311 C57BL/6J ±  kb
transcript OTTMUST00000088606 VEGA | MGI Sequence Detail 7338 Not Applicable  
polypeptide OTTMUSP00000048306 VEGA | MGI Sequence Detail 2155 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    897 from dbSNP Build 137
  • PCR
Protein
Information
less
Molecular
Reagents
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  • All nucleic 9
    Genomic 1
    cDNA 6
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39574
References
more
  • Summaries
    All 46
    Developmental Gene Expression 9
    Diseases 2
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:39295 Legan PK, et al., The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system. J Biol Chem. 1997 Mar 28;272(13):8791-801
  • Latest
    J:221167 Urness LD, et al., Fgf10 is required for specification of non-sensory regions of the cochlear epithelium. Dev Biol. 2015 Apr 1;400(1):59-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory