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Tecta
Gene Detail
 Symbol
Name
ID
Tecta
tectorin alpha
MGI:109575
Synonyms [a]-tectorin, Tctna
Feature Type protein coding gene
Genetic Map
Chromosome 9
23.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:42329619-42399929 bp, - strand
From VEGA annotation of GRCm38

  70311 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tecta

Human
homologs
Human Homolog TECTA, tectorin alpha
NCBI Gene ID 7007
neXtProt AC  NX_O75443
Human Synonyms  DFNA12, DFNA8, DFNB21
Human Chr (Location)  11q22-q24; chr11:121102666-121191493 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TECTA
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
 
Homozygous null mice exhibit a tectorial membrane that is detached from the cochlear epithelium. Though the basilar membranes of mutant mice are tuned, sensitivity is attenuated. Mice with an Y1870C mutation have a disrupted tectorial membrane, elevated neural thresholds and broadened neural tuning.
 
Human Diseases Modeled Using Mouse Tecta (1)    Alleles Annotated to Human Diseases(4)   
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell-matrix adhesion, sensory perception of sound
Component anchored component of membrane, extracellular region, ...
Function extracellular matrix structural constituent, protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (56)    Tissues (22)    Images (25)
Theiler Stages: 19, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 52
RT-PCR 4
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(6) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034859 (Evidence)
Ensembl Gene ModelENSMUSG00000037705 (Evidence)
Entrez Gene21683 (Evidence)
UniGene42209
DFCITC1586380
DoTSDT.55272982, DT.97352267
NIA Mouse Gene IndexU030751
Consensus CDS ProjectCCDS23087.1
International Mouse Knockout Project StatusTecta
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034859 VEGA Gene Model | MGI Sequence Detail 70311 C57BL/6J ±  kb
transcript OTTMUST00000088606 VEGA | MGI Sequence Detail 7338 Not Applicable 
polypeptide OTTMUSP00000048306 VEGA | MGI Sequence Detail 2155 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(15) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(897 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR003886 Nidogen, extracellular domain
InterPro IPR025615 TILa domain
InterPro IPR002919 Trypsin Inhibitor-like, cysteine rich domain
InterPro IPR014853 Uncharacterised domain, cysteine-rich
InterPro IPR001007 von Willebrand factor, type C
InterPro IPR001846 von Willebrand factor, type D domain
InterPro IPR006552 VWC out
InterPro IPR001507 Zona pellucida domain
InterPro IPR017977 Zona pellucida domain, conserved site
Protein Ontology PR:000016222 alpha-tectorin
References (Earliest) J:39295 Legan PK, et al., The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system. J Biol Chem. 1997 Mar 28;272(13):8791-801
(Latest) J:203482 Legan PK, et al., Three Deaf Mice: Mouse Models for TECTA-based Human Hereditary Deafness Reveal Domain-specific Structural Phenotypes in the Tectorial Membrane. Hum Mol Genet. 2013 Dec 20;
All references(45)
Other
accession IDs
MGD-MRK-39574

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory