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Cntn4 Gene Detail
Summary
  • Symbol
    Cntn4
  • Name
    contactin 4
  • Synonyms
    Axcam, BIG-2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095737
    NCBI Gene: 269784
  • Gene Overview
    MyGene.info: CNTN4
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:105677660-106699310 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 48.93 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9731 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095737
protein coding gene Chr6:105677651-106700141 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031093
protein coding gene Chr6:107861107-108935746 (+)
A/J MGP_AJ_G0031062
protein coding gene Chr6:103744953-104765465 (+)
AKR/J MGP_AKRJ_G0030993
protein coding gene Chr6:106546234-107592245 (+)
BALB/cJ MGP_BALBcJ_G0031073
protein coding gene Chr6:103708671-104721866 (+)
C3H/HeJ MGP_C3HHeJ_G0030635
protein coding gene Chr6:76739112-77803331 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031532
protein coding gene Chr6:110637509-111771759 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028696
protein coding gene Chr6:101236735-102227097 (+)
CAST/EiJ MGP_CASTEiJ_G0030180
protein coding gene Chr6:106931664-108002888 (+)
CBA/J MGP_CBAJ_G0030759
protein coding gene Chr6:114957492-116107328 (+)
DBA/2J MGP_DBA2J_G0030912
protein coding gene Chr6:102890316-103900667 (+)
FVB/NJ MGP_FVBNJ_G0030866
protein coding gene Chr6:101982665-102997112 (+)
LP/J MGP_LPJ_G0030992
protein coding gene Chr6:107963940-109025002 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030900
protein coding gene Chr6:119101106-120363157 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031559
protein coding gene Chr6:106527739-107587335 (+)
PWK/PhJ MGP_PWKPhJ_G0029896
protein coding gene Chr6:101865264-102898350 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029724
protein coding gene Chr6:105378023-106417367 (+)
WSB/EiJ MGP_WSBEiJ_G0030264
protein coding gene Chr6:107036439-108109569 (+)



Homology
more
  • Human Ortholog
    CNTN4, contactin 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CNTN4, contactin 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AXCAM, BIG-2
  • Links
    NCBI Gene ID: 152330
    neXtProt AC: NX_Q8IWV2
    UniProt: Q8IWV2

  • Chr Location
    3p26.3-p26.2; chr3:2098771-3059080 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 14257
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CNTN4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit aberrant projection of olfactory axons to multiple glomeruli in the olfactory bulb.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064293 Ensembl Gene Model | MGI Sequence Detail 1021651 C57BL/6J ±  kb
    transcript ENSMUST00000089208 Ensembl | MGI Sequence Detail 5179 Not Applicable  
    polypeptide ENSMUSP00000086616 Ensembl | MGI Sequence Detail 1026 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 10
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:41456 Mimmack ML, et al., A novel splice variant of the cell adhesion molecule BIG-2 is expressed in the olfactory and vomeronasal neuroepithelia. Brain Res Mol Brain Res. 1997 Jul;47(1-2):345-50
    • Latest
      J:237301 Nikolaienko RM, et al., Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues. J Biol Chem. 2016 Oct 07;291(41):21335-21349

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory