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Pros1
Gene Detail
 Symbol
Name
ID
Pros1
protein S (alpha)
MGI:1095733
Synonyms protein S
Feature Type protein coding gene
Genetic Map
Chromosome 16
36.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:62854307-62929346 bp, + strand
From VEGA annotation of GRCm38

  75040 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:264  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: plasma protein S
Gene Tree: Pros1

Human
homologs
Human Homolog PROS1, protein S (alpha)
NCBI Gene ID 5627
neXtProt AC  NX_P07225
Human Synonyms  PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6
Human Chr (Location)  3q11.2; chr3:93873037-93974090 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human PROS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality associated with thrombosis, hemorrhage, and thrombocytopenia.
 
Interactions
Pros1 interacts with 174 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process blood coagulation, fibrinolysis, ...
Component blood microparticle, extracellular region, ...
Function calcium ion binding, protein complex binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (42)    Tissues (14)    Images (22)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 33
RT-PCR 9
cDNA source data(94)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027260 (Evidence)
Ensembl Gene ModelENSMUSG00000022912 (Evidence)
Entrez Gene19128 (Evidence)
UniGene127156
DFCITC1595102, TC1654251, TC1660651
DoTSDT.87068898, DT.94299946
NIA Mouse Gene IndexU017245
Consensus CDS ProjectCCDS28263.1
International Mouse Knockout Project StatusPros1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027260 VEGA Gene Model | MGI Sequence Detail 75040 C57BL/6J ±  kb
transcript OTTMUST00000067401 VEGA | MGI Sequence Detail 3303 Not Applicable 
polypeptide OTTMUSP00000033908 VEGA | MGI Sequence Detail 675 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(354 from dbSNP Build 137)    SNPs within 2kb including multiple locations(362)
Protein-related
information
ResourceIDDescription
InterPro IPR017857 Coagulation factor, subgroup, Gla domain
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000013269 vitamin K-dependent protein S
References (Earliest) J:17594 Chu MD, et al., Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S. Biochim Biophys Acta. 1994 Apr 6;1217(3):325-8
(Latest) J:208244 Carrera Silva EA, et al., T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity. 2013 Jul 25;39(1):160-70
All references(40)
Other
accession IDs
MGI:2146630

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory