Pros1
Gene Detail

Symbol Name ID

Pros1 protein S (alpha) MGI:1095733

Synonyms

protein S

Feature Type

protein coding gene

Genetic Map

Chromosome 16

36.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:62854307-62929346 bp, + strand From VEGA annotation of GRCm38   75040 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:264  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: plasma protein S
Gene Tree: Pros1

Human homologs

Human Homolog		PROS1, protein S (alpha)
NCBI Gene ID		5627
neXtProt AC		NX_P07225
Human Synonyms		PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6
Human Chr (Location)		3q11.2; chr3:93591881-93692934 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PROS1

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Mice homozygous for a knock-out allele exhibit neonatal lethality associated with thrombosis, hemorrhage, and thrombocytopenia.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	blood coagulation, fibrinolysis, ...
Component	extracellular region, extracellular space, ...
Function	calcium ion binding, protein complex binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (42)    Tissues (14)    Images (22)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	33
RT-PCR	9

cDNA source data(91)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(92) cDNA(91) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000027260 (Evidence)
Ensembl Gene Model	ENSMUSG00000022912 (Evidence)
Entrez Gene	19128 (Evidence)
UniGene	127156
DFCI	TC1595102, TC1654251, TC1660651
DoTS	DT.87068898, DT.94299946
NIA Mouse Gene Index	U017245
Consensus CDS Project	CCDS28263.1
International Mouse Knockout Project Status	Pros1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027260	VEGA Gene Model | MGI Sequence Detail	75040	C57BL/6J
transcript	OTTMUST00000067401	VEGA | MGI Sequence Detail	3303	Not Applicable
polypeptide	OTTMUSP00000033908	VEGA | MGI Sequence Detail	675	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(334 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017857	Coagulation factor, subgroup, Gla domain
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro	IPR001791	Laminin G domain
Protein Ontology	PR:000013269	vitamin K-dependent protein S

References

(Earliest) J:17594 Chu MD, et al., Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S. Biochim Biophys Acta. 1994 Apr 6;1217(3):325-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)

Other accession IDs

MGI:2146630