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Pros1
Gene Detail
Symbol

Name
ID
Pros1
protein S (alpha)
MGI:1095733
Synonyms
protein S
Feature Type
protein coding gene
Genetic Map
Chromosome 16
36.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:62854307-62929346 bp, + strand
From VEGA annotation of GRCm38

  75040 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:264  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PROS1
Protein SuperFamily: plasma protein S
Gene Tree: Pros1

Human
homologs
PROS1, protein S (alpha)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5627
neXtProt AC: NX_P07225

Human Synonyms: PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6

Human Chr (Location): 3q11.2; chr3:93873037-93974090 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human PROS1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality associated with thrombosis, hemorrhage, and thrombocytopenia.
 
Interactions
Pros1 interacts with 173 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process blood coagulation, fibrinolysis, ...
Component blood microparticle, extracellular exosome, ...
Function calcium ion binding, protein complex binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (42)    Tissues (14)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 33
RT-PCR 9
cDNA source data(94)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pros1 ; ZFIN pros1    NEW 
Molecular
reagents
All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027260 (Evidence)
Ensembl Gene Model ENSMUSG00000022912 (Evidence)
Entrez Gene 19128 (Evidence)
UniGene 127156
DFCI TC1660651, TC1654251, TC1595102
DoTS DT.94299946, DT.87068898
NIA Mouse Gene Index U017245
Consensus CDS Project CCDS28263.1
International Mouse Phenotyping Consortium Status Pros1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027260 VEGA Gene Model | MGI Sequence Detail 75040 C57BL/6J ±  kb
transcript OTTMUST00000067401 VEGA | MGI Sequence Detail 3303 Not Applicable 
polypeptide OTTMUSP00000033908 VEGA | MGI Sequence Detail 675 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(354 from dbSNP Build 137)    SNPs within 2kb including multiple locations(362)
Protein-related
information
ResourceIDDescription
InterPro IPR017857 Coagulation factor, subgroup, Gla domain
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000013269 vitamin K-dependent protein S
References
(Earliest) J:17594 Chu MD, et al., Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S. Biochim Biophys Acta. 1994 Apr 6;1217(3):325-8
(Latest) J:218039 Lew ED, et al., Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. Elife. 2014;3
All references(40)
Other
accession IDs
MGI:2146630

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory