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Pros1 Gene Detail
Summary
  • Symbol
    Pros1
  • Name
    protein S (alpha)
  • Synonyms
    protein S
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095733
    NCBI Gene: 19128
  • Gene Overview
    MyGene.info: PROS1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:62854307-62929346 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      75040 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 36.43 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PROS1, protein S
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PROS1, protein S
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6
  • Links
    NCBI Gene ID: 5627
    neXtProt AC: NX_P07225
    UniProt: P07225

  • Chr Location
    3q11.1; chr3:93873037-93974090 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 5 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality associated with thrombosis, hemorrhage, and thrombocytopenia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027260 VEGA Gene Model | MGI Sequence Detail 75040 C57BL/6J ±  kb
    transcript OTTMUST00000067401 VEGA | MGI Sequence Detail 3303 Not Applicable  
    polypeptide OTTMUSP00000033908 VEGA | MGI Sequence Detail 675 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      349 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013269 vitamin K-dependent protein S
    • InterPro Domains
      IPR017857 Coagulation factor-like, Gla domain superfamily
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
      IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR001791 Laminin G domain
      IPR033189 Vitamin K-dependent protein S
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 94
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146630
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:17594 Chu MD, et al., Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S. Biochim Biophys Acta. 1994 Apr 6;1217(3):325-8
    • Latest
      J:248070 Tashima Y, et al., Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions. PLoS One. 2017;12(7):e0180981

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/03/2018
    MGI 6.12
    The Jackson Laboratory