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Wbp4 Gene Detail
Summary
  • Symbol
    Wbp4
  • Name
    WW domain binding protein 4
  • Synonyms
    FBP21
  • Feature Type
    protein coding gene
  • IDs
    MGI:109568
    NCBI Gene: 22380
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:79697377-79718708 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 42.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    475 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109568
 protein coding gene Chr14:79697377-79718960 (-)
129S1/SvImJ ENSMUSG00200009025
 protein coding gene Chr14:68141129-68162715 (-)
A/J ENSMUSG00195003967
 protein coding gene Chr14:68269841-68291433 (-)
AKR/J ENSMUSG00220007248
 protein coding gene Chr14:67647576-67669162 (-)
BALB/cJ ENSMUSG00180021760
 protein coding gene Chr14:67861517-67883101 (-)
C3H/HeJ ENSMUSG00175028057
 protein coding gene Chr14:69671516-69693100 (-)
C57BL/6NJ ENSMUSG00215019155
 protein coding gene Chr14:67864225-67885809 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019542
 protein coding gene Chr14:70273116-70294872 (-)
CAST/EiJ ENSTCUG00005029626
 protein coding gene Chr14:69532460-69554061 (-)
CBA/J ENSMUSG00210009756
 protein coding gene Chr14:68283679-68305265 (-)
DBA/2J ENSMUSG00185009000
 protein coding gene Chr14:73444263-73465851 (-)
FVB/NJ ENSMUSG00205018724
 protein coding gene Chr14:67694410-67715993 (-)
JF1/MsJ ENSUMUG00000017928
 protein coding gene Chr14:84606653-84628016 (-)
LP/J ENSMUSG00230002430
 protein coding gene Chr14:85478407-85499991 (-)
NOD/ShiLtJ ENSMUSG00190010025
 protein coding gene Chr14:68110262-68131847 (-)
NZO/HlLtJ ENSMUSG00225025127
 protein coding gene Chr14:75759027-75780611 (-)
PWK/PhJ ENSLUMG00010010586
 protein coding gene Chr14:67458653-67480237 (-)
SPRET/EiJ ENSMSPG00010000202
 protein coding gene Chr14:71129264-71148819 (-)
WSB/EiJ ENSIUOG00005021508
 protein coding gene Chr14:67458663-67480485 (-)



Homology
more
  • Human Ortholog
    WBP4, WW domain binding protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WBP4, WW domain binding protein 4
  • Synonyms
    FBP21, NEDHFDB
  • Links
    NCBI Gene ID: 11193
    UniProt: O75554

  • Chr Location
    13q14.11; chr13:41061509-41084006 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Wbp4
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    14 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    633
  • Tissues
    24
  • cDNA Data
    16
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22380 NCBI Gene Model | MGI Sequence Detail 21332 C57BL/6J ±  kb
transcript NM_018765 RefSeq | MGI Sequence Detail 3452 C57BL/6  
polypeptide Q61048 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1
    Antibodies 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-39567, MGI:2145825, MGI:2145850
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:38792 Chan DC, et al., Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 1996 Mar 1;15(5):1045-54
  • Latest
    J:140465 Guo G, et al., Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory