Sp100 MGI Mouse Gene Detail - MGI:109561

Symbol

Sp100
Name

nuclear antigen Sp100
Synonyms

A430075G10Rik

Feature Type

protein coding gene
IDs

MGI:109561
NCBI Gene: 20684
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:85649988-85709998 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 43.60 cM
Mapping Data

4 experiments

SNPs within 2kb

238 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109561	protein coding gene	Chr1:85649948-85709998 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016233	protein coding gene	Chr1:86824029-86914415 (+)
A/J	MGP_AJ_G0016214	protein coding gene	Chr1:83629535-83702115 (+)
AKR/J	MGP_AKRJ_G0016175	protein coding gene	Chr1:86062545-86123699 (+)
BALB/cJ	MGP_BALBcJ_G0016171	protein coding gene	Chr1:83764142-83827327 (+)
C3H/HeJ	MGP_C3HHeJ_G0015999	protein coding gene	Chr1:86339060-86386457 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016625	protein coding gene	Chr1:90088011-90223832 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014348	protein coding gene	Chr1:78112571-78172676 (+)
CAST/EiJ	MGP_CASTEiJ_G0015584	protein coding gene	Chr1:85572302-85618466 (+)
CBA/J	MGP_CBAJ_G0015975	protein coding gene	Chr1:92972938-93043930 (+)
DBA/2J	MGP_DBA2J_G0016077	protein coding gene	Chr1:82955680-83019911 (+)
FVB/NJ	MGP_FVBNJ_G0016077	protein coding gene	Chr1:81875932-82067511 (+)
LP/J	MGP_LPJ_G0016149	protein coding gene	Chr1:87955754-88023199 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016103	protein coding gene	Chr1:96257899-96335910 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016669	protein coding gene	Chr1:86171410-86246748 (+)
PWK/PhJ	MGP_PWKPhJ_G0015371	protein coding gene	Chr1:82223813-82287870 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015151	protein coding gene	Chr1:85149052-85203820 (+)
WSB/EiJ	MGP_WSBEiJ_G0015647	protein coding gene	Chr1:85852849-85904918 (+)

Human Ortholog

SP100, SP100 nuclear antigen

Vertebrate Orthologs

2

Human Ortholog

SP100, SP100 nuclear antigen
Orthology source: HGNC
Synonyms

lysp100b
Links

HGNC:11206

NCBI Gene ID: 6672

neXtProt AC: NX_P23497

UniProt: P23497
Chr Location

2q37.1; chr2:230416156-230545602 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 86761
1 mouse;1 rat
HCOP

human homology predictions: SP100
Gene Tree

Sp100

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Sp100
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

0 strains or lines available

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All GO Annotations

9
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

114
cDNA Data

35
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Sp100 interacts with 320 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

116
RefSeq

30
UniProt

16
CCDS

CCDS35639.1, CCDS83567.1, CCDS83568.1, CCDS83569.1

Ensembl

ENSMUSG00000026222 (Evidence)
NCBI Gene

20684

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026222	Ensembl Gene Model \| MGI Sequence Detail	60011	C57BL/6J	± kb
transcript	ENSMUST00000066427	Ensembl \| MGI Sequence Detail	2708	Not Applicable
polypeptide	ENSMUSP00000066399	Ensembl \| MGI Sequence Detail	591	Not Applicable

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UniProt

16 Sequences
InterPro Domains

IPR001487 Bromodomain

IPR036427 Bromodomain-like superfamily

IPR004865 HSR domain

IPR043563 Nuclear body protein Sp110/Sp140/Sp140L

IPR000770 SAND domain

IPR010919 SAND-like domain superfamily

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

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All nucleic 50

Genomic 11

cDNA 39

Microarray probesets 6

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MGD-MRK-39560, MGI:2443000

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 6
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Sp100:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7672	Chr1:85649997-85650004 (+)	13 bp
Tssr7673	Chr1:85650008-85650020 (+)	26 bp
Tssr7674	Chr1:85650027-85650042 (+)	47 bp
Tssr7675	Chr1:85650044-85650052 (+)	60 bp
Tssr7680	Chr1:85673706-85673723 (+)	23,727 bp
Tssr7681	Chr1:85681071-85681109 (+)	31,102 bp
Tssr7689	Chr1:85709333-85709361 (+)	59,359 bp
Tssr7690	Chr1:85709387-85709403 (+)	59,407 bp
Tssr7691	Chr1:85709419-85709433 (+)	59,438 bp
Tssr7692	Chr1:85709450-85709461 (+)	59,468 bp
Tssr7693	Chr1:85709593-85709617 (+)	59,617 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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