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Ptprr Gene Detail
Summary
  • Symbol
    Ptprr
  • Name
    protein tyrosine phosphatase, receptor type, R
  • Synonyms
    PTPBR7, PTP-SL, RPTPRR
  • Feature Type
    protein coding gene
  • IDs
    MGI:109559
    NCBI Gene: 19279
  • Gene Overview
    MyGene.info: PTPRR
Location & Maps
more
  • Sequence Map
    Chr10:116018213-116274932 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      256720 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 64.01 cM, cytoband A2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PTPRR, protein tyrosine phosphatase, receptor type R
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPRR, protein tyrosine phosphatase, receptor type R
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EC-PTP, PCPTP1, PTPBR7, PTPRQ, PTP-SL
  • Links
    NCBI Gene ID: 5801
    neXtProt AC: NX_Q15256

  • Chr Location
    12q15; chr12:70638073-70920804 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 2135
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PTPRR
  • Gene Tree
    Ptprr
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Ptprr
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for a knock-out allele exhibit increased ERK1/2 phosphorylation levels in cerebellar Purkinje cells, decreased grip strength, and ataxia characterized by fine motor coordination and balance defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    78
  • Tissues
    27
  • cDNA Data
    21
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026109 VEGA Gene Model | MGI Sequence Detail 256720 C57BL/6J ±  kb
transcript OTTMUST00000064458 VEGA | MGI Sequence Detail 3619 Not Applicable  
polypeptide OTTMUSP00000032010 VEGA | MGI Sequence Detail 656 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1337 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013478 receptor-type tyrosine-protein phosphatase R
  • PDB
    1JLN
  • EC
    3.1.3.48
  • InterPro Domains
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR008356 Protein-tyrosine phosphatase, KIM-containing
    IPR029021 Protein-tyrosine phosphatase-like
    IPR016334 Protein-tyrosine phosphatase, receptor type R/non-receptor type 5
    IPR000242 PTP type protein phosphatase
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
less
  • All nucleic 26
    Genomic 1
    cDNA 23
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-39558
References
more
  • Summaries
    All 42
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:22419 Hendriks W, et al., A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. Biochem J. 1995 Jan 15;305(Pt 2):499-504
  • Latest
    J:212986 Erkens M, et al., Protein tyrosine phosphatase receptor type R deficient mice exhibit increased exploration in a new environment and impaired novel object recognition memory. Behav Brain Res. 2014 May 15;265:111-20
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory