Terc Gene Detail

Summary

• Symbol
  Terc
• Name
  telomerase RNA component
• Synonyms
  mTER, mTR

• Feature Type
  telomerase RNA gene
  BioType Conflict
  
• IDs
  MGI:109558
  NCBI Gene: 21748
• Alliance
  genome feature page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr3:96321753-96322149 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 41.82 cM, cytoband F/G
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  102 from dbSNP Build 142
• Strain Annotations
  34

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	no annotation		Chr3:96321753-96322175 (-)
129S1/SvImJ	ENSMUSG00200045468	lncRNA gene	Chr3:92955119-92955515 (-)
129S1/SvImJ	ENSMUSG00200045527	unclassified non-coding RNA gene	Chr3:92955119-92955541 (-)
A/J	ENSMUSG00195048258	unclassified non-coding RNA gene	Chr3:93351383-93351805 (-)
A/J	ENSMUSG00195048232	lncRNA gene	Chr3:93351383-93351779 (-)
AKR/J	ENSMUSG00220040878	lncRNA gene	Chr3:91699541-91699937 (-)
AKR/J	ENSMUSG00220041026	unclassified non-coding RNA gene	Chr3:91699541-91699963 (-)
BALB/cJ	ENSMUSG00180040993	unclassified non-coding RNA gene	Chr3:93300304-93300726 (-)
BALB/cJ	ENSMUSG00180040938	lncRNA gene	Chr3:93300304-93300700 (-)
C3H/HeJ	ENSMUSG00175032608	lncRNA gene	Chr3:92909816-92910212 (-)
C3H/HeJ	ENSMUSG00175032691	unclassified non-coding RNA gene	Chr3:92909816-92910238 (-)
C57BL/6NJ	ENSMUSG00215040168	unclassified non-coding RNA gene	Chr3:93676934-93677356 (-)
C57BL/6NJ	ENSMUSG00215040113	lncRNA gene	Chr3:93676934-93677330 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005020169	lncRNA gene	Chr3:93501204-93501600 (-)
CAST/EiJ	ENSTCUG00005020188	unclassified non-coding RNA gene	Chr3:93501204-93501626 (-)
CBA/J	ENSMUSG00210051501	lncRNA gene	Chr3:93462834-93463230 (-)
CBA/J	ENSMUSG00210051514	unclassified non-coding RNA gene	Chr3:93462834-93463256 (-)
DBA/2J	ENSMUSG00185047416	unclassified non-coding RNA gene	Chr3:93917957-93918379 (-)
DBA/2J	ENSMUSG00185047366	lncRNA gene	Chr3:93917957-93918353 (-)
FVB/NJ	ENSMUSG00205050606	unclassified non-coding RNA gene	Chr3:92571221-92571643 (-)
FVB/NJ	ENSMUSG00205050586	lncRNA gene	Chr3:92571221-92571617 (-)
JF1/MsJ	ENSUMUG00000048142	unclassified non-coding RNA gene	Chr3:92774380-92774802 (-)
JF1/MsJ	ENSUMUG00000048053	lncRNA gene	Chr3:92774380-92774776 (-)
LP/J	ENSMUSG00230046197	lncRNA gene	Chr3:95886975-95887371 (-)
LP/J	ENSMUSG00230046230	unclassified non-coding RNA gene	Chr3:95886975-95887397 (-)
NOD/ShiLtJ	ENSMUSG00190047038	unclassified non-coding RNA gene	Chr3:94015666-94016088 (-)
NOD/ShiLtJ	ENSMUSG00190046972	lncRNA gene	Chr3:94015666-94016062 (-)
NZO/HlLtJ	ENSMUSG00225012356	unclassified non-coding RNA gene	Chr3:98262393-98262815 (-)
NZO/HlLtJ	ENSMUSG00225012354	lncRNA gene	Chr3:98262393-98262789 (-)
PWK/PhJ	ENSLUMG00010032118	unclassified non-coding RNA gene	Chr3:92767335-92767757 (-)
PWK/PhJ	ENSLUMG00010032053	lncRNA gene	Chr3:92767335-92767731 (-)
SPRET/EiJ	ENSMSPG00010045912	unclassified non-coding RNA gene	Chr3:93064678-93065100 (-)
SPRET/EiJ	ENSMSPG00010045863	lncRNA gene	Chr3:93064678-93065074 (-)
WSB/EiJ	ENSIUOG00005031153	unclassified non-coding RNA gene	Chr3:93416978-93417400 (-)
WSB/EiJ	ENSIUOG00005031097	lncRNA gene	Chr3:93416978-93417374 (-)

Human Diseases

• Diseases
  1 with Terc mouse models

Human Disease

Mouse Models

osteoporosis

IDs

osteoporosis      

DOID:11476
EFO:0003882
ICD10CM:M81.0
ICD9CM:733.0
ICD9CM:733.00
MESH:D010024
NCI:C3298
OMIM:166710
UMLS_CUI:C0029456

View 2 models

Mouse Models

Human Disease Modeled: osteoporosis

Allelic Composition	Genetic Background	Reference	Phenotypes
Terctm1Rdp/Terctm1Rdp	B6J.Cg-Terc^tm1Rdp	J:213181	View
Terctm1Rdp/Terctm1Rdp Wrntm1Lgu/Wrntm1Lgu	involves: 129/Sv * BALB/c * C57BL/6 * SLJ	J:213181	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  5 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  72 phenotypes from 1 allele in 4 genetic backgrounds
  107 phenotypes from multigenic genotypes
  2 images
  213 phenotype references
  

• All Mutations and Alleles
  7
• Endonuclease-mediated
  5
• Gene trapped
  1
• Targeted
  1
• Find Mice (IMSR)
  8 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Early generation mice homozygous for a null allele have intact telomeres and appear grossly unaffected and healthy, whereas late generation mutants exhibit premature death, shortened and dysfunctional telomeres, apoptotic and proliferative defects, infertility, and multi-organ degenerative decline.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  13
• GO References
  7

Expression

• Assay Results
  6
• Tissues
  2
• cDNA Data
  2
• Literature Summary
  2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  42
• RefSeq
  1

• Ensembl
  ENSMUSG00000118406 (Evidence), ENSMUSG00002075569 (Evidence)
• NCBI Gene
  21748

Representative Sequences			Length	Strain/Species
genomic	21748	NCBI Gene Model | MGI Sequence Detail	397	C57BL/6J
transcript	NR_001579	RefSeq | MGI Sequence Detail	397	Not Specified

Molecular
Reagents

• All nucleic 4

  Genomic 2

  cDNA 2

  
  

  Microarray probesets 1

Other
Accession IDs

MGD-MRK-39557

References

• Summaries
  All 250

  Developmental Gene Expression 2

  Diseases 5

  Gene Ontology 7

  Phenotypes 213
• Earliest
  J:28425 Blasco MA, et al., Functional characterization and developmental regulation of mouse telomerase RNA. Science. 1995 Sep 1;269(5228):1267-70
• Latest
  J:391908 Liu B, et al., Senescent microglia with shortened telomeres secrete soluble DLK1 to induce aging-associated hypomyelination and neuronal dysfunction. Neuron. 2026 Aug 11;

TSS for Terc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34624	Chr3:96322141-96322155 (-)	1 bp