Terc
Gene Detail

Symbol Name ID

Terc telomerase RNA component MGI:109558

Synonyms

mTER, mTR

Feature Type

telomerase RNA gene

Genetic Map

Chromosome 3

41.82 cM, cytoband F/G
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:96414437-96414833 bp, - strand From NCBI annotation of GRCm38   397 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Gene Tree: Terc

Alleles and phenotypes

All alleles(2) : Targeted(1) Gene trapped(1)
 

Early generation mice homozygous for a null allele have intact telomeres and appear grossly unaffected and healthy, whereas late generation mutants exhibit premature death, shortened and dysfunctional telomeres, apoptotic and proliferative defects, infertility, and multi-organ degenerative decline.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cell proliferation, hematopoietic stem cell differentiation, ...
Component	telomerase holoenzyme complex
Function	telomerase activity, template for synthesis of G-rich strand of telomere DNA activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (2)   
Theiler Stages: 20, 22

Assay Type	Results
Northern blot	6

cDNA source data(2)
External Resources: GEO  

Molecular reagents

All nucleic(4) Genomic(2) cDNA(2)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000064796 (Evidence)
Entrez Gene	21748 (Evidence)
DFCI	TC1623162
DoTS	DT.91282048
NIA Mouse Gene Index	U024386
International Mouse Knockout Project Status	Terc

Sequences

Length	Strain/Species
genomic	21748	NCBI Gene Model | MGI Sequence Detail	397	C57BL/6J
transcript	NR_001579	RefSeq | MGI Sequence Detail	397	Not Specified

All sequences(9) RefSeq(1)

References

(Earliest) J:28425 Blasco MA, et al., Functional characterization and developmental regulation of mouse telomerase RNA. Science. 1995 Sep 1;269(5228):1267-70
(Latest) J:195250 Ghosh A, et al., Telomerase directly regulates NF-kappaB-dependent transcription. Nat Cell Biol. 2012 Dec;14(12):1270-81
All references(151)

Other accession IDs

MGD-MRK-39557