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Terc Gene Detail
Summary
  • Symbol
    Terc
  • Name
    telomerase RNA component
  • Synonyms
    mTER, mTR
  • Feature Type
    telomerase RNA gene
  • IDs
    MGI:109558
    NCBI Gene: 21748
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 3, 41.82 cM, cytoband F/G
  • Mapping Data
    2 experiments
Homology
less
Human Diseases
more
  • Diseases
    1 with Terc mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 1 allele in 4 genetic backgrounds
    102 phenotypes from multigenic genotypes
    2 images
    155 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Early generation mice homozygous for a null allele have intact telomeres and appear grossly unaffected and healthy, whereas late generation mutants exhibit premature death, shortened and dysfunctional telomeres, apoptotic and proliferative defects, infertility, and multi-organ degenerative decline.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21748 NCBI Gene Model | MGI Sequence Detail 397 C57BL/6J ±  kb
    transcript NR_001579 RefSeq | MGI Sequence Detail 397 Not Specified  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      2 from dbSNP Build 142
    Molecular
    Reagents
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    • All nucleic 4
      Genomic 2
      cDNA 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-39557
    References
    more
    • Summaries
      All 187
      Developmental Gene Expression 1
      Diseases 5
      Gene Ontology 7
      Phenotypes 155
    • Earliest
      J:28425 Blasco MA, et al., Functional characterization and developmental regulation of mouse telomerase RNA. Science. 1995 Sep 1;269(5228):1267-70
    • Latest
      J:244124 Theodoris CV, et al., Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency. J Clin Invest. 2017 May 01;127(5):1683-1688

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory