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Terc Gene Detail
Summary
  • Symbol
    Terc
  • Name
    telomerase RNA component
  • Synonyms
    mTER, mTR
  • Feature Type
    telomerase RNA gene
  • IDs
    MGI:109558
    NCBI Gene: 21748
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:96414437-96414833 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 41.82 cM, cytoband F/G
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109558
telomerase RNA gene Chr3:96414437-96414859 (-)
129S1/SvImJ MGP_129S1SvImJ_G0009682
unclassified non-coding RNA gene Chr3:97271341-97271763 (-)
A/J MGP_AJ_G0009668
unclassified non-coding RNA gene Chr3:94193656-94194078 (-)
AKR/J MGP_AKRJ_G0009651
unclassified non-coding RNA gene Chr3:96395603-96396025 (-)
BALB/cJ MGP_BALBcJ_G0009650
unclassified non-coding RNA gene Chr3:93994772-93995194 (-)
C3H/HeJ MGP_C3HHeJ_G0009583
unclassified non-coding RNA gene Chr3:96674439-96674861 (-)
C57BL/6NJ MGP_C57BL6NJ_G0009892
unclassified non-coding RNA gene Chr3:100807728-100808150 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0009403
unclassified non-coding RNA gene Chr3:95959079-95959501 (-)
CBA/J MGP_CBAJ_G0009556
unclassified non-coding RNA gene Chr3:104519515-104519937 (-)
DBA/2J MGP_DBA2J_G0009584
unclassified non-coding RNA gene Chr3:93490157-93490579 (-)
FVB/NJ MGP_FVBNJ_G0009601
unclassified non-coding RNA gene Chr3:91522673-91523095 (-)
LP/J MGP_LPJ_G0009678
unclassified non-coding RNA gene Chr3:98569004-98569426 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0009569
unclassified non-coding RNA gene Chr3:110597326-110597748 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0009865
unclassified non-coding RNA gene Chr3:96016924-96017346 (-)
PWK/PhJ MGP_PWKPhJ_G0009326
unclassified non-coding RNA gene Chr3:93340971-93341393 (-)
SPRET/EiJ MGP_SPRETEiJ_G0009163
unclassified non-coding RNA gene Chr3:94293280-94293702 (-)
WSB/EiJ MGP_WSBEiJ_G0009503
unclassified non-coding RNA gene Chr3:96432963-96433385 (-)



Homology
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Human Diseases
more
  • Diseases
    1 with Terc mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 1 allele in 4 genetic backgrounds
    102 phenotypes from multigenic genotypes
    2 images
    162 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Early generation mice homozygous for a null allele have intact telomeres and appear grossly unaffected and healthy, whereas late generation mutants exhibit premature death, shortened and dysfunctional telomeres, apoptotic and proliferative defects, infertility, and multi-organ degenerative decline.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21748 NCBI Gene Model | MGI Sequence Detail 397 C57BL/6J ±  kb
    transcript NR_001579 RefSeq | MGI Sequence Detail 397 Not Specified  
    For the selected sequence
    Molecular
    Reagents
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    • All nucleic 4
      Genomic 2
      cDNA 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-39557
    References
    more
    • Summaries
      All 194
      Developmental Gene Expression 1
      Diseases 5
      Gene Ontology 7
      Phenotypes 162
    • Earliest
      J:28425 Blasco MA, et al., Functional characterization and developmental regulation of mouse telomerase RNA. Science. 1995 Sep 1;269(5228):1267-70
    • Latest
      J:266102 Tang H, et al., HuR regulates telomerase activity through TERC methylation. Nat Commun. 2018 Jun 7;9(1):2213

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory