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Psmc2 Gene Detail
Summary
  • Symbol
    Psmc2
  • Name
    proteasome (prosome, macropain) 26S subunit, ATPase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109555
    NCBI Gene: 19181
  • Gene Overview
    MyGene.info: PSMC2
Location & Maps
more
  • Sequence Map
    Chr5:21785283-21803787 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18505 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PSMC2, proteasome 26S subunit, ATPase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PSMC2, proteasome 26S subunit, ATPase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MSS1, Nbla10058, S7
  • Links
    NCBI Gene ID: 5701
    neXtProt AC: NX_P35998

  • Chr Location
    7q22.1-q22.3; chr7:103344405-103369395 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotype references
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    2
  • Gene trapped
    24
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Psmc2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024688 VEGA Gene Model | MGI Sequence Detail 18505 C57BL/6J ±  kb
transcript OTTMUST00000060718 VEGA | MGI Sequence Detail 1785 Not Applicable  
polypeptide OTTMUSP00000029652 VEGA | MGI Sequence Detail 475 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    143 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013379 26S protease regulatory subunit 7
  • InterPro Domains
    IPR005937 26S proteasome subunit P45
    IPR003593 AAA+ ATPase domain
    IPR003960 ATPase, AAA-type, conserved site
    IPR003959 ATPase, AAA-type, core
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 16
    Genomic 1
    cDNA 13
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-39554
References
more
  • Summaries
    All 40
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:40216 Gordon C, et al., Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Nature. 1993 Nov 25;366(6453):355-7
  • Latest
    J:196249 Lukic Z, et al., TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. Retrovirology. 2011;8:93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory